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Patients with the same genetic mutation for vitamin D-resistant rickets showed different symptoms but all improved with treatment except for hair loss.

Inhibitors of the enzyme 5 alpha-reductase could potentially treat disorders like prostate cancer and baldness.

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

Tunisian children with hereditary vitamin D-resistant rickets showed improvement with calcium treatment, and new genetic mutations were identified.

Fzd2 is important for skin and hair development through various signaling ways.

Four patients with a type of rickets and hair loss had different mutations in their vitamin D receptor gene, causing it to not work properly.

5α-reductases increase epitestosterone's effect on androgen receptors.

RXR agonists may promote hair growth in humans.

RXRa is crucial for Th2 immune cell development and may link nutrition to immune health.

Certain derivatives are more effective 5α-reductase type 2 inhibitors than finasteride.

A new enzyme in rats may help regulate hair growth.

The enzyme 5α-reductase is important for proper blood vessel development during the fertility-related transformation of the uterus lining.

New mutations in the VDR gene cause vitamin D-resistant rickets without hair loss.

Finasteride effectively inhibits the enzyme steroid 5 alpha-reductase II.

The vitamin D receptor can work without its usual activating molecule.

Retinoids are important for treating skin conditions but should be used with caution due to serious side effects and risks during pregnancy.

A new method allows for controlled, long-lasting delivery of retinoic acid through the skin with fewer side effects.

All five human steroid 5α-reductase enzymes are found in the endoplasmic reticulum.

Type 3 5α-reductase is more common and finasteride and dutasteride strongly inhibit it.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

The document concludes that the 5 alpha-reductase enzymes are important in steroid metabolism and related to various human diseases, with inhibitors used to treat conditions like male pattern baldness and prostate issues.

The treatment cleared psoriasis in some patients but caused side effects in most.

The new synthetic retinoid RO 13-6298 effectively treated severe psoriasis at low doses with manageable side effects.

The human type II 5α-reductase gene has a specific structure important for understanding certain medical conditions.

SMR-2 and SMR-6 are much more toxic than retinoic acid, causing severe side effects.

The enzyme 5α-reductase type 1 is important for blood vessel development and fertility in the uterus.

High doses of certain vitamins can cause serious side effects and health risks.