127 citations
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July 2002 in “EMBO journal” Normal skin cell renewal doesn't need RAR signaling, but vitamin A-related skin thickening does.
12 citations
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October 1978 in “PubMed” Ro 10-9359 is an effective treatment for severe psoriasis but can cause side effects.
October 1940 in “Clinical and Experimental Optometry” Vitamin A deficiency can cause eye problems and other health issues.
The treatment was not recommended due to limited effectiveness and significant side effects.
January 2023 in “Journal of cosmetic dermatology” The synthetic retinoid EC23 thickens skin and promotes hair growth more effectively and with a lower dose than natural retinoids.
January 2023 in “Cutaneous and Ocular Toxicology” Roaccutane can cause severe liver damage.
High concentrations of retinoic acid kill hair follicle stem cells, while low concentrations may help treat skin diseases.
19 citations
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March 2011 in “Cutaneous and Ocular Toxicology” Some chemicals absorbed through the skin can cause serious health problems.
September 2010 in “Reactions weekly” The combination of tretinoin, minoxidil, and betamethasone valerate may cause severe scalp inflammation.
31 citations
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February 1982 in “Archives of dermatology” Etretinate was effective for certain skin conditions, but caused side effects like chapped lips, dry mucous membranes, and hair loss.
Retinoids or their analogs could treat skin pigmentation disorders like melasma and vitiligo.
10 citations
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March 1990 in “The Journal of Dermatology” Long-term etretinate use may cause delayed wound healing and extra tissue growth after injury.
August 2024 in “Journal of Dermatology & Cosmetology” Acitretin effectively prevented skin cancer in a patient with late-onset Rothmund-Thomson syndrome.
143 citations
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May 2002 in “PubMed” LGD1069 effectively prevents breast tumors in mice without toxicity.
March 2002 in “Clin-Alert” In 2002, various drugs caused serious side effects, including vitamin B12 deficiency, heart issues, blindness, hypersexuality, allergic reactions, blood clotting problems, pupil dilation, capillary leak syndrome, muscle breakdown, hepatitis, skin reactions, and lupus.
44 citations
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September 1948 in “Radiology” Too much vitamin A can cause serious health problems.
October 2019 in “CRC Press eBooks” Retinoids can both cause and treat different hair disorders.
January 1993 in “Side effects of drugs annual” Natural products like propolis are causing more skin allergies, and certain skin treatments and medications have various side effects and risks.
September 2025 in “Texila international journal of public health” Isotretinoin effectively treats severe acne but can affect blood and inflammation markers, posing risks for some people.
September 2020 in “Journal of Education, Health and Sport” Most patients on isotretinoin for acne experience mild, dose-related side effects, but the connection to depression or bowel disease is uncertain.
Acitretin treatment unexpectedly darkened a patient's gray hair.
2 citations
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August 2002 in “British Journal of Ophthalmology” Tangent screens help detect visual field defects from vigabatrin.
41 citations
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October 2019 in “Biomolecules” Retinoic acid can either maintain stem cells or make them specialize, depending on the cell type.
17 citations
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April 2004 in “Acta Clinica Belgica” UV light makes skin signs of lack of carotene and vitamin A more visible.
24 citations
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September 2005 in “Journal of Cellular Biochemistry” Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.
March 2023 in “Ukrainian Journal of Dermatology Venerology Cosmetology” The improved tretinoin lotion effectively treats acne with minimal irritation, even in children as young as 9.
69 citations
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March 2016 in “American journal of clinical dermatology” Topical retinoids effectively improve photodamaged skin.
36 citations
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July 2017 in “Journal of controlled release” A new method allows for controlled, long-lasting delivery of retinoic acid through the skin with fewer side effects.
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February 1996 in “Journal of Investigative Dermatology”