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Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

Glucocorticoids reduce fat production in liver cells, while androgens increase it in females; manipulating certain enzymes can influence these effects.

Different parts of cells interact at specific areas to control cell functions like energy production and fat storage.

UVB exposure increases skin proteins for retinoic acid synthesis and shifts their location, possibly affecting skin repair.

Metabolism plays a key role in determining stem cell fate.

Retinoic acid affects male and female muscle energy use and function differently.

Non-coding RNA boosts retinoic acid production and signaling, aiding regeneration.

Retinoids increase steroid sulfatase activity in leukemia cells through RARα/RXR and involves certain pathways like phosphoinositide 3-kinase and ERK-MAP kinase.

Doctors need to recognize and treat metabolic disorders in children early to prevent serious health issues.

New pyrazole-based inhibitors show promise for treating metabolic diseases and other conditions.

The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.

Mitochondrial Complex I reduces inflammation and increases bone breakdown by affecting certain immune cells.

Finasteride metabolism varies by age, sex, and P450 inducers, with males processing it faster.

4-(Ethoxycarbophenyl) retinamide is much less toxic than other retinoids.

Lipid metabolism affects wool thickness in sheep.

The method reliably profiles eicosanoids and shows epitestosterone reduces their levels, similar to common anti-inflammatory drugs.

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

The P133R mutation in AKR1D1 enzyme causes harmful bile acid buildup, explaining related health issues.

The study developed a tool to predict how gut microbes process foods and drugs, showing that similar compounds often share metabolic pathways and effects.

Rapamycin treatment helps reduce brain inflammation and symptoms of mitochondrial disease by blocking specific pathways in mice.

These methods help understand cell structures and reactions.

Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.

50-mg ritlecitinib capsules are bioequivalent to 100-mg capsules.

Blocking autophagy worsens lipid buildup and dysfunction in brain cells after injury.

Proteasome inhibitors are promising treatments for various cancers, autoimmune diseases, and other conditions.

Two genetic disorders affect biotin metabolism, causing severe skin, hair, and metabolic issues.

A man's chest hair turned white after a shingles infection, possibly due to virus-damaged pigment cells.

Key enzymes control androgen levels, affecting hormone activity and potential treatments.