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Three siblings with a rare genetic condition had abnormal sexual development and chose different gender identities, needing surgery and therapy.

The retinoid receptor antagonist effectively disrupts vitamin A-related development in embryos.

Lhx2 is a crucial regulator of the Sonic Hedgehog signaling in early mouse retinal development.

The hydrogel patch helps heal diabetic wounds by releasing a healing agent in response to harmful molecules and improving skin regeneration.

CAR-T therapy offers hope for children with hard-to-treat blood cancers.

Prostaglandin D2 increases testosterone levels in skin cells through reactive oxygen species, not enzymes, which could lead to new hair loss treatments.

Removing Ctip2 in skin cells causes skin inflammation similar to atopic dermatitis.

A rare skin condition was confirmed to be associated with a specific virus in a young girl.

Skin's Regulatory T cells are crucial for maintaining skin health and could be targeted to treat immune-related skin diseases and cancer.

T cell subsets are crucial in kidney cancer, and a new model predicts patient outcomes using key genes.

A new mutation in the STS gene causes X-linked ichthyosis, even in rare female cases.

TET enzymes are important for skin and hair development by controlling gene activity in specific areas.

Ritlecitinib effectively improves hair growth in alopecia areata patients, regardless of hair loss pattern.

IL-2 treatment causes skin eruptions and other reversible side effects, and may play a role in psoriasis.

A family was found with both Trichorhinophalangeal syndrome and Loose Anagen Syndrome, suggesting a genetic connection.

Combining PRS with TAFR is promising for treating complex fistulas, with most patients achieving long-term healing.

Blocking certain receptors in the lungs might help treat a specific type of asthma.

Roots adapt to uneven environments by changing growth and gene expression.

The conclusion is that Treg-targeted therapies have potential, but more knowledge of Treg biology is needed for effective treatments, including for cancer.

The ACTH/MC2R system is crucial for controlling hair growth cycles in mice.

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

Breast cancer treatments work better with AR activation, improving results and reducing side effects.

Krt15+ cells in the mouse intestine resist radiation and can start tumors.

Finasteride may help reduce COVID-19 infection by altering a key gene.

Tissue environment greatly affects the unique epigenetic makeup of regulatory T cells, which could impact autoimmune disease treatment.

Long-read RNA sequencing can identify complex gene changes in IFAP syndrome.

Scientists restored fertility in male mice lacking a key fertility gene by using a modified gene.

The rs1128977 gene variant may affect cholesterol and body measurements.

Keeping human skin stem cells is easier with low temperatures and mTOR inhibition.