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Asiaticoside (AS), derived from Centella asiatica, shows significant potential in enhancing wound healing after endoscopic submucosal dissection (ESD) by promoting mucosal regeneration. AS accelerates healing through anti-inflammatory effects, oxidative stress reduction, and fibrosis inhibition, while also promoting angiogenesis and collagen synthesis. Despite its efficacy in skin wounds, AS's application in gastrointestinal contexts is limited by poor bioavailability. Innovative delivery systems like hydrogels and microneedles could improve localized, sustained release, suggesting a shift from passive acid suppression to active mucosal regeneration in ESD management. Future research should focus on developing endoscope-compatible delivery methods to enhance clinical application and reduce complications.

This study demonstrates that periodic exposure to red light can mitigate aging in mice by enhancing histone H3 Lys9 acetylation (H3K9ac) through the modulation of fatty acid metabolism. Red light exposure reduces SIRT4 protein levels in keratinocytes, which activates glycolysis, fatty acid metabolism, and the TCA cycle. The decrease in SIRT4 enhances mitochondrial fatty acid oxidation and activates SIRT1, which in turn alleviates inhibition on PPAR-α, leading to increased expression of lipid metabolism-related genes. This results in the accumulation of acetyl-CoA, increased H3K9ac levels, and altered expression of senescence-related genes, effectively reducing cellular aging through coordinated regulation of metabolism, inflammation, and gene expression.