35 citations
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October 2017 in “Signal Transduction and Targeted Therapy” Fibromodulin treatment helps reduce scarring and improves wound healing by making it more like fetal healing.
26 citations
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September 2018 in “Colloids and Surfaces B: Biointerfaces” A new liposome treatment helps heal deep burns on mice by improving hair regrowth and reducing scarring.
18 citations
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January 2022 in “Oxidative Medicine and Cellular Longevity” Fibroblasts are crucial in scar formation and wound healing, with potential therapies aiming for scarless healing.
13 citations
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April 2025 in “International Journal of Nanomedicine” The new gallic acid hydrogel speeds up wound healing and reduces scarring.
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January 1988 in “PubMed” Epidermal cell extracts improve skin healing and reduce scarring.
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January 2018 in “Organogenesis” Porcine acellular dermal matrix treatment helps wounds heal faster and reduces scarring by affecting Jag1 in skin stem cells.
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January 1995 in “Aesthetic Plastic Surgery” New suturing technique with wider intervals and shallow stitches helps prevent scalp scars and promotes hair growth.
April 2023 in “The Egyptian Journal of Histology” Platelet-rich plasma helps heal second-degree burns and reduces scarring.
August 2022 in “Research Square (Research Square)” Implanted special stem cells from hair follicles helped heal wounds faster and with less scarring in mice.
April 2018 in “Journal of Investigative Dermatology” Fetuin A may increase collagen production and promote scarring.
2 citations
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November 2014 in “International Scholarly Research Notices” The terpenoid fraction may cause thicker scars by delaying wound healing.
January 2025 in “Open Medicine” High-concentration cell-free adipose extract reduces scar formation and improves scar appearance.
21 citations
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December 2023 in “Bioengineering & Translational Medicine” Fibroblast and endothelial cell interactions are crucial in forming hypertrophic scars.
5 citations
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September 2023 in “Journal of Cosmetic Dermatology” c-Maf positive macrophages help form hypertrophic scars by affecting fibroblasts and collagen production.
April 2026 in “Journal of Pharmaceutical Investigation” Nanotechnology could improve treatment for scars and atopic dermatitis by targeting skin issues more effectively.
102 citations
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April 2014 in “PloS one” Wharton’s Jelly stem cells from the umbilical cord improve skin healing and hair growth without scarring.
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January 2020 in “Scientific Reports” The African spiny mouse heals skin without scarring due to different protein activity compared to the common house mouse, which heals with scarring.
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March 1998 in “Journal of Biomedical Materials Research” Island grafts can help study skin regeneration separately from other healing processes.
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September 2025 in “PLoS ONE” Actin and alpha-smooth muscle actin help skin heal in mouse fetuses.
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May 2010 in “Chinese journal of plastic surgery” Melatonin might help treat thick scars.
February 2026 in “Exploration” Advancements in gene therapy, stem cells, and biomaterials show promise for reducing scarring in wound healing, but face clinical challenges.
10 citations
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January 2018 in “Elsevier eBooks” Burn scars heal abnormally and more research is needed to find better treatments.
July 2025 in “Interdisciplinary materials” A microneedle patch with curcumin and stem cell components effectively treats hypertrophic scars and promotes healing.
August 1969 in “Archives of Dermatology” After calciphylaxis, rats showed incomplete skin and hair regeneration, resembling scar tissue with fewer hairs.
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October 2012 in “Cellular and Molecular Life Sciences” Understanding developmental pathways can improve wound healing treatments.
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March 2018 in “International journal of molecular sciences” The document concludes that the understanding of scar formation is incomplete and current prevention and treatment for hypertrophic scars and keloids are not fully effective.
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August 2016 in “Advances in wound care” New effective scar treatments are urgently needed due to the current options' limited success.
168 citations
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August 2000 in “American Journal of Pathology” Fibromodulin might help reduce scarring if increased in adult wounds like in fetal skin that heals without scars.
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October 2001 in “EMBO journal” Overexpressing follistatin in mice delays wound healing and reduces scar size.
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November 2018 in “Nature Communications” The Sonic hedgehog pathway is crucial for new hair growth during mouse skin healing.