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GlossarySebaceous Gland Activity

production of sebum by skin glands

Sebaceous gland activity refers to the function of sebaceous glands in the skin, which produce and secrete an oily substance called sebum. Sebum helps to lubricate and protect the skin and hair, but excessive activity can lead to oily skin and conditions like acne, while insufficient activity can result in dry skin.

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Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands

research Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Predominates in Human Sebaceous Glands

45 citations , September 1998 in “Journal of Investigative Dermatology”

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumors with a Predominant Reserve Cell Population

research Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumours with a Predominant Reserve Cell Population

5 citations , February 2015 in “Journal of Comparative Pathology”

High proliferative activity and peripheral invasion indicate malignancy in canine sebaceous gland tumors; the term 'epithelioma' should be updated for clarity.

research The Role of Sebaceous Gland Activity and Scalp Microfloral Metabolism in the Etiology of Seborrheic Dermatitis and Dandruff

241 citations , August 2005 in “Journal of Investigative Dermatology Symposium Proceedings”

Dandruff and seborrheic dermatitis are caused by yeast feeding on scalp oils, leading to irritation and flaking.

research Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

30 citations , April 2007 in “Dermatologic Clinics”

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

research Local stimulation of sebaceous gland activity by the topical administration of dehydroepiandrosterone

1 citations , January 1988

Topical DHEA safely increases skin oil production.

research Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands

36 citations , October 2009 in “Journal of biological chemistry/The Journal of biological chemistry”

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

research Δ5-3β-Hydroxysteroid Dehydrogenase Activity in Sebaceous Glands of Scalp in Male-Pattern Baldness

69 citations , August 1988 in “Journal of Investigative Dermatology”

Androgens Affect the Activity of Human Sebocytes in Culture Depending on the Localization of the Sebaceous Glands, and Their Effect Is Antagonized by Spironolactone

research Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone

40 citations , January 1994 in “Skin Pharmacology and Physiology”

Male hormones affect oil-producing skin cells differently based on their body location, and the drug spironolactone can reduce these effects.

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

37 citations , November 1995 in “Journal of Investigative Dermatology”

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-pattern Baldness

51 citations , January 1989 in “Journal of Investigative Dermatology”

Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.

research Acne and sebaceous gland function

463 citations , September 2004 in “Clinics in dermatology”

Effective acne treatments should reduce sebum, bacteria, and inflammation, with isotretinoin being the best for severe cases.

research Mitotic activity in the epidermis of the rabbit stimulated with local applications of testosterone propionate

25 citations , April 1949 in “The journal of experimental zoology”

Testosterone applied to rabbit skin increases skin cell growth and changes skin structure.

research The Effects of Rosemary Oil on the Activities of Enzyme and Expression of Cytokine Relevant to Hair Growth in C57BL/6 Mice

January 2010 in “Jounal of The Korean Society of cosmetology”

Rosemary oil may promote hair growth by enhancing enzyme activities and IGF-1 expression.

research TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis

91 citations , June 2011 in “The EMBO Journal”

TCF/Lef1 activity is essential for proper skin cell development and renewal.

research Depositing α-mangostin nanoparticles to sebaceous gland area for acne treatment

50 citations , November 2015 in “Journal of pharmacological sciences”

α-mangostin nanoparticles improved acne with minimal irritation.

Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

research Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche.

10 citations , August 1998 in “Journal of Investigative Dermatology”

The compounds tested could potentially treat hair loss and alopecia.

research ANTI-ACNE ACTIVITY OF LIPIDO-STEROLIC EXTRACT OF SERENOA REPENS AND HYDRO-ALCOHOLIC EXTRACT OF GLYCYRRHIZA GLABRA IN SYRIAN HAMSTER EAR MODEL

September 2017 in “Zenodo (CERN European Organization for Nuclear Research)”

Liquorice extract may help treat acne by reducing sebum production.

research Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

70 citations , August 2006 in “Cancer Research”

AP-1 controls tumor cell type by affecting key signaling pathways.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface

research Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface

41 citations , October 2008 in “The American journal of pathology”

Blocking a specific protein signal can make hair grow on mouse nipples.

Determination of Secondary Follicle Characteristics, Density, Activity, and Hoxc13 Expression Pattern of Hexi Cashmere Goat Breed

research Determination of Secondary Follicle Characteristics, Density, Activity, and Hoxc13 Expression Pattern of Hexi Cashmere Goats Breed

7 citations , June 2015 in “The anatomical record”

Hexi cashmere goats' hair growth varies by stage, with Hoxc13 linked to hair activity.

Male Skin and Ingredients Relevant to Male Skin Care

research Mitotic processes in hair follicles and the morphostructure of sheep skin upon inclusion of a water-soluble fatty acid complex into their diets

April 2025 in “Ukrainian Journal of Veterinary and Agricultural Sciences”

Adding a water-soluble fatty acid complex to sheep diets improves wool growth by increasing primary hair follicle size and density.

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Related Terms

Research

research Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Predominates in Human Sebaceous Glands

research Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumours with a Predominant Reserve Cell Population

research The Role of Sebaceous Gland Activity and Scalp Microfloral Metabolism in the Etiology of Seborrheic Dermatitis and Dandruff

research Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

research Local stimulation of sebaceous gland activity by the topical administration of dehydroepiandrosterone

research Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands

research Δ5-3β-Hydroxysteroid Dehydrogenase Activity in Sebaceous Glands of Scalp in Male-Pattern Baldness

research Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-pattern Baldness

research Acne and sebaceous gland function

research Mitotic activity in the epidermis of the rabbit stimulated with local applications of testosterone propionate

research The Effects of Rosemary Oil on the Activities of Enzyme and Expression of Cytokine Relevant to Hair Growth in C57BL/6 Mice

research TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis

research Depositing α-mangostin nanoparticles to sebaceous gland area for acne treatment

research ANTI-ACNE ACTIVITY OF LIPIDO-STEROLIC EXTRACT OF SERENOA REPENS AND HYDRO-ALCOHOLIC EXTRACT OF GLYCYRRHIZA GLABRA IN SYRIAN HAMSTER EAR MODEL

research Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

research Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface

research Determination of Secondary Follicle Characteristics, Density, Activity, and Hoxc13 Expression Pattern of Hexi Cashmere Goats Breed

research Male skin and ingredients relevant to male skin care

research New developments in our understanding of acne pathogenesis and treatment

research ANDROGEN METABOLISM AS IT AFFECTS HAIR GROWTH IN ANDROGENETIC ALOPECIA

research Differentiation of Mouse Induced Pluripotent Stem Cells into a Multipotent Keratinocyte Lineage

research Nanoparticles enhance therapeutic outcome in inflamed skin therapy

research Updated Treatment for Acne: Targeted Therapy Based on Pathogenesis

research Matriptase Expression and Zymogen Activation in Human Pilosebaceous Unit

research Mitotic processes in hair follicles and the morphostructure of sheep skin upon inclusion of a water-soluble fatty acid complex into their diets