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GlossarySebaceous Gland Atrophy

shrinkage of oil-producing skin glands

Sebaceous gland atrophy refers to the shrinkage or degeneration of the sebaceous glands, which are small oil-producing glands in the skin. This condition can lead to reduced sebum production, resulting in dry skin and potentially contributing to hair loss, as sebum plays a role in maintaining healthy hair and scalp.

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research Mycobacterium avium subspecies hominissuis infection in a dog from Germany with multifocal alopecia, exfoliative dermatitis, hypercalcaemia and subsequent sebaceous atrophy

9 citations , January 2015 in “Veterinary record case reports”

A dog in Germany was successfully treated for a rare bacterial infection without spreading it to humans.

research Pharmacological Inhibition of Stearoyl CoA Desaturase in the Skin Induces Atrophy of the Sebaceous Glands

25 citations , February 2013 in “The journal of investigative dermatology/Journal of investigative dermatology”

Blocking SCD1 in the skin with XEN103 shrinks sebaceous glands in mice.

research TNF‐inhibitor associated psoriatic alopecia: Diagnostic utility of sebaceous lobule atrophy

20 citations , March 2017 in “Journal of cutaneous pathology”

Shrinking of oil glands in the skin is a key sign of hair loss linked to TNF inhibitor drugs and may improve if the treatment is stopped.

research Adenohypophysitis Associated with Sebaceous Gland Atrophy in a Dog

11 citations , July 1991 in “Veterinary Pathology”

A dog had a rare skin condition linked to gland and pituitary issues.

Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

research Pharmacological Inhibition of DGAT1 Induces Sebaceous Gland Atrophy in Mouse and Dog Skin While Overt Alopecia Is Restricted to the Mouse

6 citations , August 2014 in “Toxicologic pathology”

Blocking DGAT1 reduces oil gland size in mice and dogs, but only mice experience hair loss.

research Sebaceous gland atrophy due to seborrheic dermatitis in a patient with alopecia: A potential pitfall

April 2024 in “Journal of cutaneous pathology”

Skin conditions like seborrheic dermatitis can make it harder to correctly diagnose hair loss because they can cause the oil glands in the skin to shrink.

A Morphometric and Histologic Study of the Scalp in Psoriasis: Paradoxical Sebaceous Gland Atrophy and Decreased Hair Shaft Diameters Without Alopecia

research A morphometric and histologic study of the scalp in psoriasis. Paradoxical sebaceous gland atrophy and decreased hair shaft diameters without alopecia.

15 citations , May 1989 in “PubMed”

Psoriasis on the scalp causes smaller oil glands and thinner hair but doesn't lead to hair loss.

research Endogenous retinoids in the hair follicle and sebaceous gland

50 citations , September 2011 in “Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids”

Maintaining the right amount of retinoic acid is crucial for healthy hair and skin.

research Study regarding the microscopic aspects of pilo-sebaceous units after antiandrogen treatment in hirsute women.

January 2015 in “PubMed”

Antiandrogen treatment helps reduce hair follicles and sebaceous glands in hirsute women.

research Use of Condensed Nanofat Combined With Fat Grafts to Treat Atrophic Scars

62 citations , October 2017 in “JAMA facial plastic surgery”

Condensed nanofat with fat grafts effectively improves atrophic facial scars.

research Updated Management of Atrophic Post Acne Scars: Review Article

October 2021 in “The Egyptian Journal of Hospital Medicine ”

Combination therapies work better than single treatments for atrophic acne scars.

research Morphologic and immunologic characterization of a canine isthmus mural folliculitis resembling pseudopelade of humans

13 citations , March 2000 in “Veterinary Dermatology”

Dogs have a skin condition like human pseudopelade, causing hair loss that doesn't improve with treatment.

research The disintegrin/metalloproteinase Adam10 is essential for epidermal integrity and Notch-mediated signaling

134 citations , January 2011 in “Development”

Adam10 enzyme is crucial for healthy skin and proper Notch signaling.

research Lichen planopilaris

5 citations , August 2001 in “International Journal of Dermatology”

A 20-year-old had hair loss and skin issues from lichen planopilaris starting at age 10.

research Comparative histopathological analyses of non-scarring alopecia in systemic lupus erythematosus patients in Lagos Nigeria

March 2023 in “Nigerian Journal of Clinical Practice”

The main difference in hair loss for lupus patients is smaller and fewer sebaceous glands.

research Histomorphological changes of the skin and hair follicles caused by different diseases in dogs with alopecia

January 2016 in “Lithuanian University of Health Sciences”

Different diseases cause specific skin and hair follicle changes in dogs with alopecia.

research The Effect of Hairless Mutant Gene on The Thymus and Skin Under The C_(57)BL/6 Genetic Background

January 2004 in “Laboratory Animal Science and Administration”

The hairless mutant gene causes early hair loss and affects skin and thymus development in mice.

research Effects of anabolic-androgenic steroids on the pilosebaceous unit.

16 citations , August 1992 in “PubMed”

Anabolic-androgenic steroids can cause skin issues like acne and oily skin by enlarging oil glands and changing skin oils.

research Drug-induced alopecia after dupilumab therapy

49 citations , December 2018 in “JAAD case reports”

Dupilumab may cause significant hair loss, which can reverse after stopping the drug.

research Horizontal and vertical sections of scalp biopsy specimens from dermatomyositis patients with scalp involvement

16 citations , February 2018 in “Journal of The American Academy of Dermatology”

Scalp biopsies from dermatomyositis patients show chronic hair loss without scarring, with mucin and blood vessel changes being very common.

research 1H NMR-based lipidomics of rodent fur: species-specific lipid profiles and SCD1 inhibitor-related dermal toxicity

5 citations , April 2014 in “Journal of Lipid Research”

SCD1 inhibitors can cause skin issues in rodents.

research Aberrant Wnt Signaling Induces Comedo-Like Changes in the Murine Upper Hair Follicle

4 citations , December 2021 in “The journal of investigative dermatology/Journal of investigative dermatology”

Overactive Wnt signaling in mouse skin stem cells causes acne-like cysts and shrinking oil glands, which some treatments can partially fix.

research Psoriatic Alopecia in a Patient with Systemic Lupus Erythematosus

3 citations , March 2017 in “Case Reports in Dermatology”

A woman with lupus improved significantly from scalp hair loss after treatment, highlighting the need to identify psoriatic alopecia in lupus patients to avoid permanent hair loss.

research A clinical and diagnostic approach of a dog with hyperadrenocorticism and hypothyroidism related: Case report

1 citations , January 2016 in “Revista Brasileira de Higiene e Sanidade Animal”

Combining lab tests with clinical observations is crucial for diagnosing hormonal skin issues in dogs.

Scalp Psoriasis: Alopecia and Treatment Challenges

research Scalp Psoriasis

July 2018 in “Elsevier eBooks”

Scalp psoriasis can cause different types of hair loss, with some patients developing permanent hair loss, and treatment may be stopped due to skin reactions.

research SnapshotDx Quiz: September 2016

August 2016 in “Journal of Investigative Dermatology”

Scalp psoriasis features reversible hair loss and specific immune activation, with no significant hair follicle damage.

research 332 Generation of a gene expression signature for sebaceous glands by transcriptome comparison of psoriasis and sebaceous hyperplasia

April 2016 in “The journal of investigative dermatology/Journal of investigative dermatology”

Sebaceous gland atrophy and abnormal function may contribute to hair loss in psoriasis.

research Ichthyosis fetalis in a cross‐bred lamb

1 citations , June 2017 in “Veterinary dermatology”

A cross-bred lamb with severe skin and movement issues had ichthyosis fetalis but normal vitamin A levels.

research Distinctive histopathologic findings in linear morphea (en coup de sabre) alopecia

19 citations , March 2013 in “Journal of Cutaneous Pathology”

The study found unique skin changes in a rare type of alopecia linked to a skin condition called linear morphea.

research Aberrant Wnt signalling induces comedo-like changes in the upper hair follicle

1 citations , October 2020 in “Research Square (Research Square)”

Abnormal Wnt signaling in hair follicle stem cells can lead to acne-like cysts.