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GlossarySebaceous Gland Activity

production of sebum by skin glands

Sebaceous gland activity refers to the function of sebaceous glands in the skin, which produce and secrete an oily substance called sebum. Sebum helps to lubricate and protect the skin and hair, but excessive activity can lead to oily skin and conditions like acne, while insufficient activity can result in dry skin.

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Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumors with a Predominant Reserve Cell Population

research Histopathological Findings and Proliferative Activity of Canine Sebaceous Gland Tumours with a Predominant Reserve Cell Population

5 citations , February 2015 in “Journal of Comparative Pathology”

High proliferative activity and peripheral invasion indicate malignancy in canine sebaceous gland tumors; the term 'epithelioma' should be updated for clarity.

Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase Predominates in Human Sebaceous Glands

research Oxidative Activity of the Type 2 Isozyme of 17β-Hydroxysteroid Dehydrogenase (17β-HSD) Predominates in Human Sebaceous Glands

45 citations , September 1998 in “Journal of Investigative Dermatology”

The enzyme 17β-HSD type 2 mainly performs oxidation in human sebaceous glands, which may help protect against acne.

research Pharmacologic Modulation of Sebaceous Gland Activity: Mechanisms and Clinical Applications

30 citations , April 2007 in “Dermatologic Clinics”

The document concludes that new treatments are needed to better manage acne and reduce side effects related to current therapies.

research Local stimulation of sebaceous gland activity by the topical administration of dehydroepiandrosterone

1 citations , January 1988

Topical DHEA safely increases skin oil production.

research Identification of Anabolic Selective Androgen Receptor Modulators with Reduced Activities in Reproductive Tissues and Sebaceous Glands

36 citations , October 2009 in “Journal of biological chemistry/The Journal of biological chemistry”

Two new compounds were found to build bone and muscle without affecting reproductive organs and skin oil glands.

research Δ5-3β-Hydroxysteroid Dehydrogenase Activity in Sebaceous Glands of Scalp in Male-Pattern Baldness

69 citations , August 1988 in “Journal of Investigative Dermatology”

Androgens Affect the Activity of Human Sebocytes in Culture Depending on the Localization of the Sebaceous Glands, and Their Effect Is Antagonized by Spironolactone

research Androgens Affect the Activity of Human Sebocytes in Culture in a Manner Dependent on the Localization of the Sebaceous Glands and Their Effect Is Antagonized by Spironolactone

40 citations , January 1994 in “Skin Pharmacology and Physiology”

Male hormones affect oil-producing skin cells differently based on their body location, and the drug spironolactone can reduce these effects.

research Depositing α-mangostin nanoparticles to sebaceous gland area for acne treatment

50 citations , November 2015 in “Journal of pharmacological sciences”

α-mangostin nanoparticles improved acne with minimal irritation.

research Acne and sebaceous gland function

463 citations , September 2004 in “Clinics in dermatology”

Effective acne treatments should reduce sebum, bacteria, and inflammation, with isotretinoin being the best for severe cases.

research Increased Androgen Binding Capacity in Sebaceous Glands in Scalp of Male-pattern Baldness

51 citations , January 1989 in “Journal of Investigative Dermatology”

Men with male-pattern baldness have more androgen receptors in their scalp's oil glands, which may contribute to hair loss.

research Effect of cyproterone acetate on hair growth, sebaceous secretion and endocrine parameters in a hirsute subject

66 citations , October 1977 in “British journal of dermatology/British journal of dermatology, Supplement”

Cyproterone acetate reduces hair growth and oil production.

research Mice lacking the epidermal retinol dehydrogenases SDR16C5 and SDR16C6 display accelerated hair growth and enlarged meibomian glands

16 citations , September 2019 in “Journal of biological chemistry/The Journal of biological chemistry”

Mice without certain skin enzymes have faster hair growth and bigger eye glands.

research TCF/Lef1 activity controls establishment of diverse stem and progenitor cell compartments in mouse epidermis

91 citations , June 2011 in “The EMBO Journal”

TCF/Lef1 activity is essential for proper skin cell development and renewal.

research ANTI-ACNE ACTIVITY OF LIPIDO-STEROLIC EXTRACT OF SERENOA REPENS AND HYDRO-ALCOHOLIC EXTRACT OF GLYCYRRHIZA GLABRA IN SYRIAN HAMSTER EAR MODEL

September 2017 in “Zenodo (CERN European Organization for Nuclear Research)”

Liquorice extract may help treat acne by reducing sebum production.

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

37 citations , November 1995 in “Journal of Investigative Dermatology”

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

research Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

70 citations , August 2006 in “Cancer Research”

AP-1 controls tumor cell type by affecting key signaling pathways.

research Mitotic activity in the epidermis of the rabbit stimulated with local applications of testosterone propionate

25 citations , April 1949 in “The journal of experimental zoology”

Testosterone applied to rabbit skin increases skin cell growth and changes skin structure.

research The Effects of Rosemary Oil on the Activities of Enzyme and Expression of Cytokine Relevant to Hair Growth in C57BL/6 Mice

January 2010 in “Jounal of The Korean Society of cosmetology”

Rosemary oil may promote hair growth by enhancing enzyme activities and IGF-1 expression.

research Sebaceous glands changes following topical application of citral

14 citations , September 1983 in “Acta Dermato Venereologica”

Citral increases sebaceous gland activity in male rats.

research THE EFFECT OF TOPICALLY APPLIED γ‐ORYZANOL ON SEBACEOUS GLANDS

10 citations , February 1976 in “The Journal of Dermatology”

γ‐Oryzanol ointment increases sebaceous gland activity and sebum production.

Activity of 17β-(N-Alkyl/Arylformamido) and 17β-[(N-Alkyl/Aryl) Alkyl/Arylamido]-4-Methyl-4-Aza-5α-Androstan-3-Ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear

research Activity of 17β-(N-Alkyl/arylformamido) and 17β-[(N-Alkyl/aryl) alkyl/arylamido]-4-methyl-4-aza-5α-androstan-3-ones as 5α-Reductase Inhibitors in the Hamster Flank Organ and Ear11The research has been supported by Endorecherche that is seeking patent protection for the new compounds. F. Labrie is President of Endorecherche.

10 citations , August 1998 in “Journal of Investigative Dermatology”

The compounds tested could potentially treat hair loss and alopecia.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

research Data from Activator Protein-1 Activity Regulates Epithelial Tumor Cell Identity

March 2023

Inhibiting AP-1 changes skin tumor types and affects tumor cell identity.

Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface

research Conversion of the Nipple to Hair-Bearing Epithelia by Lowering Bone Morphogenetic Protein Pathway Activity at the Dermal-Epidermal Interface

41 citations , October 2008 in “The American journal of pathology”

Blocking a specific protein signal can make hair grow on mouse nipples.

research Gate keeping the sebaceous gland

August 2023 in “bioRxiv (Cold Spring Harbor Laboratory)”

The research found that specific stem cells maintain skin gland openings and that disrupting their activity can cause blockages or early cancer signs, indicating a need for targeted treatments.

Determination of Secondary Follicle Characteristics, Density, Activity, and Hoxc13 Expression Pattern of Hexi Cashmere Goat Breed

research Determination of Secondary Follicle Characteristics, Density, Activity, and Hoxc13 Expression Pattern of Hexi Cashmere Goats Breed

7 citations , June 2015 in “The anatomical record”

Hexi cashmere goats' hair growth varies by stage, with Hoxc13 linked to hair activity.

research Sexual Hormones in Human Skin

305 citations , February 2007 in “Hormone and metabolic research”

Human skin makes sexual hormones that affect hair growth, skin health, and healing; too much can cause acne and hair loss, while treatments can manage these conditions.

research Action of isotretinoin in acne rosacea and gram-negative folliculitis

175 citations , April 1982 in “Journal of The American Academy of Dermatology”

Isotretinoin is highly effective in treating severe acne, rosacea, and gram-negative folliculitis.

research Androgen action on human skin – from basic research to clinical significance

147 citations , October 2004 in “Experimental dermatology”

Hormones like testosterone affect skin functions and can cause skin issues when in excess; treatments to manage these effects are only somewhat effective.

research Physiologic skin changes in pregnancy

141 citations , January 1984 in “Journal of The American Academy of Dermatology”

Pregnancy can cause skin darkening, varicose veins, more sweating, hair growth, hair loss after birth, nail changes, and gum inflammation.