research Hypoxia Mesenchymal Stem Cell-Derived Exosomes (EH-MSCs) enhance IGF-1 and suppress IL-1Beta in hair follicle regeneration
EH-MSCs can help regrow hair by boosting IGF-1 and reducing IL-1Beta.
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research Human skin
Estrogen deficiency, like after menopause or certain surgeries, leads to faster skin aging and health issues.
research The mineralocorticoid receptor plays a transient role in mouse skin development
The mineralocorticoid receptor temporarily affects mouse skin development, but the glucocorticoid receptor has a more lasting impact.
research A Founder Mutation in the POMC 5′-UTR Causes Proopiomelanocortin Deficiency Through Splicing-Mediated Decrease of mRNA
A specific genetic mutation causes POMC deficiency, leading to symptoms like weight gain and red hair.
research A Systematic Review of Endocrine Therapy for Improved Reproductive and Metabolic Outcomes in PCOS Women
Endocrine therapy helps with reproductive and metabolic issues in women with PCOS.
research Biomimetic cell-adhesive ligand-functionalized peptide composite hydrogels maintain stemness of human amniotic mesenchymal stem cells
This study explored the use of biomimetic cell-adhesive ligand-functionalized peptide composite hydrogels to influence the behavior of human amniotic mesenchymal stem cells (hAMSCs). The hydrogels were found to be non-cytotoxic and supported the survival, proliferation, and maintenance of stemness in hAMSCs. Additionally, the expression of pluripotent markers was upregulated, and under specific conditions, there was enhanced mineral deposition and increased mRNA expression of osteogenic genes. The study suggested that ligand-integrin interactions played a role in modulating the fate of hAMSCs within the composite hydrogels.
research Syndromes of Severe Insulin Resistance (SSIRs)
The document concludes that Syndromes of Severe Insulin Resistance are rare disorders with limited treatment options.
research Hyperandrogenic eumenorrheic NON-PCOS women versus women with PCOS after the GnRH-agonist stimulation test preceded by suppression of adrenal steroidogenesis with dexamethasone
PCOS women have more severe metabolic issues and higher androgen levels than hyperandrogenic women without PCOS.
research Effects of microenvironment and biological behavior on the paracrine function of stem cells
Mesenchymal stem cells release substances that help tissue repair, and their effectiveness can be improved by understanding environmental influences.
research Pharmacokinetics of 2 Novel Formulations of Modified-Release Oral Testosterone Alone and With Finasteride in Normal Men With Experimental Hypogonadism
New oral testosterone formulations show potential for safer, effective hormone replacement in men with low testosterone.
research Local Changes in Neurosteroid Levels in the Substantia Nigra Reticulata and the Ventral Tegmental Area Alter Chronic Ethanol Withdrawal Severity in Male Withdrawal Seizure‐Prone Mice
Ethanol withdrawal reduces the brain's response to certain calming steroids, making seizures harder to control.
research Efficacy and Safety of a Food Supplement Containing L-cystine, Serenoa repens Extract and Biotin for Hair Loss in Healthy Males and Females. A Prospective, Randomized, Double-blinded, Controlled Clinical Trial
The food supplement with L-cystine, Serenoa repens extract, and biotin safely reduced hair loss and improved hair growth in men and women.
research Androgen binding to cytosol and nuclei of hamster sebaceous glands
Dihydrotestosterone specifically binds to hamster sebaceous glands, with a higher affinity than testosterone.
research The Effect of Topical Gel Secretome Hypoxic Mesenchymal Stem Cells (SH-MSCs) on IL-6 and TGF- β Gene Expression (Experimental Study in Male Wistar Alopecia-Like Rat Models Induced by Fluconazole)
SH-MSCs gel reduced IL-6 and increased TGF-β, suggesting it could treat alopecia.
research Finasteride/testosterone
research Identification of Beta-Sitosterol and Stigmasterol as Possible Inhibitors of 5 Alpha-Reductase 1: An In-Silico Study
Beta-sitosterol and stigmasterol might help prevent hair loss by blocking a specific enzyme.
research 3D bioprinted GelMA scaffolds loaded with Runx2 overexpressed BMSCs for bone regeneration
The study explores a novel approach to bone regeneration by using 3D bioprinted methacrylated gelatin (GelMA) scaffolds loaded with Runx2-overexpressing bone marrow mesenchymal stem cells (Runx2-OE-BMSCs). The Runx2 gene, a key osteogenic transcription factor, was introduced into BMSCs using lentiviral vectors to enhance their osteogenic differentiation capacity. The resulting Runx2-OE-BMSCs@GelMA scaffolds demonstrated excellent biocompatibility and significantly improved osteogenic differentiation in vitro. In vivo experiments further confirmed their effectiveness in enhancing bone regeneration. This strategy provides new insights into treating bone defect-related diseases by focusing on enhancing osteoblast activity.
research Secondary Amenorrhea in a 15-year-old Girl
A 15-year-old girl with missed periods was diagnosed with a pituitary disorder and treated with hormones and steroids.
research Discovery of an Androgen Receptor Degrader Featuring a Pyridazinyl Glutarimide CRBN-Binding Motif for Transdermal Treatment of Androgenetic Alopecia
dAR-6–1 is a promising new treatment for hair loss that works better than minoxidil.
research Biology of estrogens in skin: implications for skin aging
Estrogens can improve skin aging but carry risks; more research is needed on safer treatments.
research 022 Randomized, double-blind, placebo-controlled, single-centre, phase I safety study of intradermal injections of autologous fibroblasts isolated from the non-bulbar dermal sheath of the hair follicle to treat skin aging
RCS-01 is safe and may help rejuvenate aging skin.
research Esthetic Surgery Applications for Adipose-Derived Stem Cells
Adipose-derived stem cells show promise for cosmetic treatments but need more research.
research Microenvironment-Responsive Recombinant Collagen XVII-Based Composite Microneedles for the Treatment of Androgenetic Alopecia
The new microneedle treatment effectively promotes hair growth better than minoxidil.
research Identification of xenobiotics interfering with 5 α -reductase (SRD5A2) activity
MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.
research 223 Canonical and Dominant Negative Peroxisome Proliferator-Activated Receptor γ Isoforms are Differentially Expressed in Human Skin and Skin Appendages
Different types of PPARγ are found in varying amounts in human skin and its parts, which could affect how skin treatments work.
research Corn silk extract improves benign prostatic hyperplasia in experimental rat model
Corn silk extract helps reduce prostate enlargement symptoms.
research Hormonal Treatment of Transgender Women with Oral Estradiol
Oral estradiol works for many transgender women but needs personalized dosing and monitoring.
research The relationship among androgens, insulin resistanceand ghrelin polymorphisms in post-adolescent malepatients with severe acne vulgaris
Lower ghrelin levels and certain gene variations may increase acne risk.
research Stromal Cells of the Human Postmenopausal Ovary Display a Distinctive Biochemical and Molecular Phenotype
Postmenopausal ovary stromal cells have a unique makeup and limited steroid production, suggesting androgens come from the adrenal gland.
research Florid Cushing's Syndrome and Hirsutism Induced by Desoximetasone
Topical corticosteroids can cause serious side effects like Cushing's syndrome and hirsutism.