292 citations
,
October 1985 in “The Journal of Cell Biology” Keratins and filaggrin change as fetal skin develops, marking key stages of skin formation.
9 citations
,
September 2019 in “PLoS ONE” K42 and K124 keratins are only found in horse hoof lamellae.
15 citations
,
May 2014 in “Journal of Biological Chemistry” A chimeric keratin partially improved skin structure in mice lacking keratin 5, but didn't fully restore normal skin.
March 2023 in “JAAD case reports” A new genetic change in the keratin 10 gene caused a skin condition called ichthyosis hystrix in a father and his daughter.
22 citations
,
July 1998 in “Journal of Investigative Dermatology” The 4C32 gene may help in mouse skin development and differentiation.
124 citations
,
December 1988 in “Differentiation” Trichocytic differentiation starts in cells with epithelial cytokeratins, transitioning to trichocytic cytokeratins in hair and gradually in nails.
248 citations
,
April 1988 in “Differentiation” Human and bovine hair follicles have distinct cytokeratins specific to hair-forming cells.
1 citations
,
January 2023 in “Biochemical and biophysical research communications” Keratin 79 is linked to liver damage and may help diagnose liver diseases.
1 citations
,
January 2019 in “Studia Biologica” Extracted keratin from wool and hair can be used in medicine and bioengineering.
November 2023 in “Advanced Science” A specific hair protein variant increases the spread of breast cancer and is linked to worse survival rates.
35 citations
,
June 2012 in “PloS one” Keratin 15 expression in skin cells is regulated by two mechanisms involving PKC/AP-1 and FOXM1.
20 citations
,
November 2003 in “American Journal Of Pathology” Fibroblasts from healthy donors can prevent changes seen in recessive epidermolysis bullosa simplex.
January 2025 in “Frontiers in Cell and Developmental Biology” Hox proteins help maintain keratinocyte identity by regulating miRNA expression.
14 citations
,
July 1994 in “Journal of Dermatological Science” Keratin mutations may cause scarring alopecia by damaging hair structure.
115 citations
,
August 2014 in “Jo'jig gonghag gwa jaesaeng uihag/Tissue engineering and regenerative medicine” Human hair keratin can be used in many medical applications.
53 citations
,
May 1988 in “Journal of Molecular Evolution” 2 citations
,
February 2021 in “FEBS open bio” Human hair keratins K85 and K35 create unique filament patterns important for early hair formation.
March 2026 in “Virulence” Vimentin and keratin help viruses spread and could be targets for antiviral treatments.
119 citations
,
September 2000 in “Journal of Biological Chemistry” GKLF/KLF4 and Sp1 control Keratin 19 gene activity, influencing cancer-related changes.
91 citations
,
December 2000 in “The journal of cell biology/The Journal of cell biology” Scientists successfully created mouse hair proteins in the lab, which are stable and similar to natural hair.
69 citations
,
January 2009 in “Advances in Materials Science and Engineering” Wool keratin is reactive, biocompatible, biodegradable, and can model keratin from other sources.
28 citations
,
December 1997 in “Journal of Biological Chemistry” A genetic mutation in the hHa1 gene creates a smaller, but still functional, hair protein without causing hair problems.
4 citations
,
April 2012 in “The journal of investigative dermatology/Journal of investigative dermatology” Krt16-deficient mice help understand skin disorders like PC and FNEPPK.
2 citations
,
January 2022 in “Materials today: proceedings” Caffeine may be good for hair growth and skin care because it binds well with keratin.
June 2025 in “Rapid Communications in Mass Spectrometry” The new method improves protein extraction and analysis in hair, aiding biomedical and forensic work.
29 citations
,
April 2003 in “Experimental dermatology” Human hair follicles grown in vitro maintain normal keratin patterns and structure.
32 citations
,
November 1998 in “Journal of Biological Chemistry” Mouse and human keratin 16 can both form filaments, with differences likely due to the tail domain, not the helical domain.
37 citations
,
August 2024 in “Current Issues in Molecular Biology” Keratins 6, 16, and 17 increase in damaged or diseased skin and may help diagnose skin issues.
12 citations
,
September 2013 in “BMC Biophysics” Keratin filaments' elasticity is influenced by their terminal domains and surrounding medium.
December 2023 in “The journal of physical chemistry. B (1997 : Online)” Human hair keratin might be good for filtering out harmful substances from water.