research Establishment of keratinocyte cell lines from human hair follicles
Scientists created keratinocyte cell lines from human hair that can differentiate similarly to normal skin cells, offering a new way to study skin biology and diseases.
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690-720 / 1000+ results research MicroRNAs in skin tissue engineering
MicroRNAs could improve skin tissue engineering by regulating cells and changing the skin's bioactive environment.
research Penetration Enhancement of Topical Formulations
New methods improve how well skin treatments work by helping drugs get through the skin barrier.
research The Story of the Finest Armor: Developmental Aspects of Reptile Skin
Reptile skin protects and prevents water loss, helping them adapt to land.
research Human Skin is a Steroidogenic Tissue: Steroidogenic Enzymes and Cofactors Are Expressed in Epidermis, Normal Sebocytes, and an Immortalized Sebocyte Cell Line (SEB-1)
Human skin can produce steroids from cholesterol.
research Experimental cutaneous Bacillus anthracis infections in hairless HRS/J mice
Hairless HRS/J mice resist Bacillus anthracis skin infections due to high numbers of immune cells, not because they lack hair follicles.
research Editors' Picks
New findings suggest targeting IL-23 could treat psoriasis, skin cells can adapt to new roles, direct conversion of skin cells to blood cells may aid cell therapy, removing certain tumor cells could boost cancer immunotherapy, and melanoma may have many tumorigenic cells, not just cancer stem cells.
research Bioengineered Skin Intended as In Vitro Model for Pharmacosmetics, Skin Disease Study and Environmental Skin Impact Analysis
Bioengineered skin models help reduce animal testing and advance research in cosmetics and skin disease.
research Proteomic Analysis of Two Stem Cell Secretomes Used in Combination in a Topical Skin Care Product That Has Demonstrated Efficacy in a Double-Blinded, Vehicle-Controlled Clinical Trial
The combined stem cell secretome in the skin care product effectively reduces inflammation and promotes tissue regeneration.
research Nanoparticles for Topical Application in the Treatment of Skin Dysfunctions—An Overview of Dermo-Cosmetic and Dermatological Products
Nanoparticles improve skin treatment but need more research on safety and effectiveness.
research Adiponectin Signaling Regulates Lipid Production in Human Sebocytes
Adiponectin boosts lipid production in skin cells, potentially helping treat skin conditions with low sebum.
research Hair follicle stem cells as a skin‐organizing signaling center during adult homeostasis
Hair follicle stem cells help maintain skin health and could improve skin replacement therapies.
research Toll-like Receptor 3 Agonist, Polyinosinic-polycytidylic Acid, Upregulates Carbonic Anhydrase II in Human Keratinocytes
A substance called poly(I:C) increases a protein called carbonic anhydrase II in skin cells, which might help with skin defense and healing.
research Editorial: Crosstalk: skin cells and immune cells in inflammatory skin diseases
Targeting specific biomarkers and immune signals is more effective and safer for treating inflammatory skin diseases.
research Proteomics as a tool to improve novel insights into skin diseases: what we know and where we should be going
Proteomics combined with other technologies can lead to a better understanding of skin diseases.
research The murine hair follicle is a melatonin target
Melatonin directly affects mouse hair follicles and may influence hair growth.
research Comparison of the Therapeutic Effect of Allogeneic and Xenogeneic Small Extracellular Vesicles in Soft Tissue Repair
Both human and animal-derived small extracellular vesicles speed up skin healing equally well.
research Nutraceuticals: A Review
Nutraceuticals may improve skin health and protect against aging, but more research is needed on their optimal use and possible health risks.
research Production of mannosylerythritol lipids and their application in cosmetics
Mannosylerythritol lipids are good for skin and hair care products.
research Wnt signaling: the good and the bad
Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.
research Design of a RADA16-based self-assembling peptide nanofiber scaffold for biomedical applications
RADA16 is a promising material for tissue repair and regenerative medicine but needs improvement in strength and cost.
research Oxidative stress management in the hair follicle: Could targeting NRF2 counter age‐related hair disorders and beyond?
Activating NRF2 might help treat hair disorders by improving antioxidant defenses.
research Current Understanding of the Pathways Involved in Adult Stem and Progenitor Cell Migration for Tissue Homeostasis and Repair
The document concludes that understanding how adult stem and progenitor cells move is crucial for tissue repair and developing cell therapies.
research Defining the identity of mouse embryonic dermal fibroblasts
Researchers identified specific genes that are important for mouse skin cell development and healing.
research Derma rollers in therapy: the transition from cosmetics to transdermal drug delivery
Derma rollers show promise for skin improvement and drug delivery, but more research is needed on their safety and effectiveness.
research Bioactive Glasses: Advancing Skin Tissue Repair through Multifunctional Mechanisms and Innovations
Bioactive glasses help heal skin wounds by promoting tissue repair and preventing infections.
research Contributions of peroxisome proliferator-activated receptor β/δ to skin health and disease
PPAR β/δ is important for skin health and disease treatment, but more research is needed.
research Hair(y) Matters in Melanoma Biology
The document concludes that the immune-inhibitory environment of the hair follicle may prevent melanoma development.
research Biological effects of human placental extracts - variations in manufacturing methods and compositions
Placental extracts have antioxidant, anti-inflammatory, and immune-boosting effects, but their exact workings are unclear.
research The Mitochondrial Blueprint of Skin Aging: From Damage Signals to Dermatologic Interventions
Targeting mitochondria can improve skin health and slow aging.