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GlossarySkin Fragility

condition where skin is unusually delicate and easily damaged

Skin fragility refers to a condition where the skin is unusually delicate and prone to damage, such as tearing, blistering, or bruising, even with minimal trauma. This can be due to genetic disorders, aging, or underlying medical conditions that affect the structural integrity of the skin, such as Ehlers-Danlos syndrome or certain types of epidermolysis bullosa. For professionals, understanding the underlying cause is crucial for managing and treating the condition effectively.

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research Histopathological and Ultrastructural Study of Ectodermal Dysplasia/Skin Fragility Syndrome

31 citations , August 2005 in “The American Journal of Dermatopathology”

The study concluded that PKP1 is essential for skin integrity and hair growth, and its dysfunction causes the symptoms of ectodermal dysplasia/skin fragility syndrome.

research Homozygous Nonsense Mutation in DSC3 Resulting in Skin Fragility and Hypotrichosis

8 citations , June 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

A boy's skin fragility and sparse hair were caused by a genetic mutation affecting skin cell adhesion.

research 474 Stabilizing mutations of KLHL24 ubiquitin ligase cause loss of keratin 14 and human skin fragility

April 2017 in “Journal of Investigative Dermatology”

Certain mutations in the KLHL24 gene cause a skin disorder by breaking down an important skin protein.

research Skin fragility in the wild-derived, inbred mouse strain Mus pahari/EiJ

December 2016 in “Experimental and Molecular Pathology”

Mus pahari mice have fragile skin due to abnormal collagen and elastin.

research Skin fragility, diffuse ecchymosis and blisters on a yellowish waxy base

April 2016 in “Journal of The American Academy of Dermatology”

A woman's skin symptoms led to a diagnosis of systemic AL amyloidosis, but she died from sepsis shortly after.

Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs

research Deficient Plakophilin-1 Expression Due to a Mutation in PKP1 Causes Ectodermal Dysplasia-Skin Fragility Syndrome in Chesapeake Bay Retriever Dogs

28 citations , February 2012 in “PLoS ONE”

A PKP1 gene mutation causes skin fragility and hair loss in Chesapeake Bay retriever puppies.

research A Scandinavian case of skin fragility, alopecia and cardiomyopathy caused byDSPmutations

11 citations , December 2013 in “Clinical and experimental dermatology”

A child with skin and heart issues had rare genetic mutations affecting skin and heart cell cohesion.

research Cryptic Patterning of Avian Skin Confers a Developmental Facility for Loss of Neck Feathering

103 citations , March 2011 in “PLoS Biology”

Birds can lose neck feathers due to a genetic change that increases a gene's activity, helping them adapt to heat.

research Skin Keratins

54 citations , November 2015 in “Methods in enzymology on CD-ROM/Methods in enzymology”

Keratins are important for skin cell health and their problems can cause diseases.

research
Effects of Skin Lightening Cream Agents – Hydroquinone and Kojic Acid, on the Skin of Adult Female Experimental Rats

46 citations , April 2020 in “Clinical Cosmetic and Investigational Dermatology”

Hydroquinone may harm skin, while kojic acid and aloe vera could reduce its negative effects.

research Investigation of age-related decline of microfibril-associated glycoprotein-1 in human skin through immunohistochemistry study

15 citations , December 2013 in “Clinical Cosmetic and Investigational Dermatology”

MAGP-1 decreases with age, leading to weaker, sagging skin.

Congenital and Hereditary Skin Diseases in Bovines

research Congenital and Hereditary Skin Diseases

January 2018

Bovines can have rare inherited skin diseases with specific symptoms like hair loss, fragile skin, and abnormal porphyrin buildup.

research Skin diseases associated with Agent Orange and other organochlorine exposures.

April 2016 in “Journal of The American Academy of Dermatology”

Certain skin diseases are linked to Agent Orange and similar chemicals; veterans should be screened and informed about uncertain risks, and current data doesn't link spironolactone with breast cancer.

research The Pathobiology of Skin Aging

122 citations , April 2020 in “American Journal Of Pathology”

Skin aging is a complex process influenced by various factors, leading to wrinkles and sagging, and should be considered a disease due to its health impacts.

research The dark and the bright sides of the transcription factor Nrf2 in skin protection and disease (Nrf2 and epidermal barrier function)

August 2015 in “Free Radical Biology and Medicine”

Nrf2 helps protect skin from damage but too much can cause skin problems.

research Epidermolysis bullosa simplex: a paradigm for disorders of tissue fragility

189 citations , July 2009 in “The Journal of clinical investigation/The journal of clinical investigation”

Epidermolysis bullosa simplex causes easily blistered skin due to faulty skin cell proteins, leading to new treatment ideas.

research Hyperaldosteronism and Hyperprogesteronism in a Cat

55 citations , August 2009 in “Journal of Feline Medicine and Surgery”

Cats with adrenal tumors may have both hyperaldosteronism and hyperprogesteronism.

research Generalized atrophic benign epidermolysis bullosa.

51 citations , January 1997 in “PubMed”

GABEB is a less severe skin condition caused by a gene mutation affecting collagen, leading to blisters and other symptoms.

research Mutations in KLHL24 Add to the Molecular Heterogeneity of Epidermolysis Bullosa Simplex

44 citations , January 2017 in “Journal of Investigative Dermatology”

Mutations in the KLHL24 gene cause skin blistering in epidermolysis bullosa simplex.

research Familial and Sporadic Porphyria Cutanea Tarda

38 citations , March 2010 in “Medicine”

Most patients with Porphyria Cutanea Tarda had skin blisters and were often affected by hepatitis C and alcohol abuse, with differences between familial and sporadic cases.

research Epidermolysis bullosa in animals: a review

33 citations , October 2014 in “Veterinary Dermatology”

Epidermolysis bullosa is a genetic disease causing fragile skin and blisters in both animals and humans.

research Inherited epidermolysis bullosa: clinical and therapeutic aspects

32 citations , April 2013 in “Anais Brasileiros de Dermatologia”

The document concludes that inherited epidermolysis bullosa is a challenging genetic condition requiring multidisciplinary care and new treatments.

research Dermatoporosis: a further step to recognition

20 citations , February 2018 in “Journal of the European Academy of Dermatology and Venereology”

Topical vitamin C may help treat skin fragility in the elderly.

research Cutaneous Toxicities From Transplantation-Related Medications

14 citations , April 2017 in “American Journal of Transplantation”

Skin problems from transplant drugs are common and need careful management in organ transplant patients.

research Porphyria Cutanea Tarda in a Patient With Agnogenic Myeloid Metaplasia

5 citations , April 1984 in “Archives of Dermatology”

Porphyria cutanea tarda causes skin issues due to an enzyme deficiency.

research Syndromic epidermolysis bullosa simplex subtype due to mutations in the KLHL24 gene: series of case reports in Russian families

3 citations , July 2024 in “Frontiers in Medicine”

Mutations in the KLHL24 gene cause a skin disorder in some Russian families.

research Clinical symptoms and sex steroid measurements in domestic ferrets (Mustela putorius furo) with hyperadrenocorticism

1 citations , December 2017 in “Research for Rural Development/Research for Rural Development (Online)”

Neutered ferrets often develop hyperadrenocorticism, with symptoms like hair loss and lethargy, and androstenedione is a key indicator for diagnosis.