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GlossarySkin Substitutes

materials used to replace or repair damaged skin

Skin substitutes are materials used to replace or aid in the repair of damaged skin, often in cases of severe burns, chronic wounds, or extensive skin loss. These can be made from natural sources like human or animal tissues, or synthetic materials designed to mimic the properties of skin, providing a temporary or permanent solution to promote healing and protect underlying tissues.

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Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and After Transplantation

research Markers to Evaluate the Quality and Self-Renewing Potential of Engineered Human Skin Substitutes In Vitro and after Transplantation

120 citations , August 2008 in “The journal of investigative dermatology/Journal of investigative dermatology”

Cytokeratin 19 and cytokeratin 15 are key markers for monitoring the quality and self-renewing potential of engineered skin.

research Prevascularization of dermal substitutes with adipose tissue-derived microvascular fragments enhances early skin grafting

57 citations , July 2018 in “Scientific Reports”

Using adipose tissue-derived fragments improves early skin graft success.

research Subpopulations of dermal skin fibroblasts secrete distinct extracellular matrix: implications for using skin substitutes in the clinic

50 citations , December 2017 in “British Journal of Dermatology”

Different skin cells produce unique materials, which can improve skin substitutes for healing.

research The influence of CD26+ and CD26− fibroblasts on the regeneration of human dermo-epidermal skin substitutes

11 citations , February 2022 in “Scientific Reports”

CD26+ fibroblasts improve skin healing and integration better than CD26− fibroblasts.

research [Employment of current results of tissue engineering in the development of skin substitutes].

January 2012 in “PubMed”

Tissue engineering advancements are improving skin substitutes for better burn treatment.

research Vascularization of skin substitute constructed by vascular endothelial growth factor 165 gene-modified hair follicle stem cells compounded with three-dimensional gelatin-chondroitin sulfate-hyaluronic acid

June 2014

The modified stem cells with VEGF165 in a special scaffold improved blood vessel growth and wound healing for skin repair.

research Characterization of Hair Follicle Development in Engineered Skin Substitutes

41 citations , June 2013 in “PLOS ONE”

Engineered skin substitutes can grow hair but have limitations like missing sebaceous glands and hair not breaking through the skin naturally.

research Assessment of replication rates of human keratinocytes in engineered skin substitutes grafted to athymic mice

12 citations , June 2012 in “Wound Repair and Regeneration”

Regulating keratinocyte growth in engineered skin can improve wound healing.

Engineered Skin Substitute Regenerates Skin with Hair Follicle Formation

research Engineered Skin Substitute Regenerates the Skin with Hair Follicle Formation

5 citations , April 2021 in “Biomedicines”

The engineered skin substitute helped grow skin with hair on mice.

research Fabrication of Bio-Based Gelatin Sponge for Potential Use as A Functional Acellular Skin Substitute

28 citations , November 2020 in “Polymers”

Crosslinked gelatin sponges show promise as skin substitutes for wound treatment.

research Composite skin substitutes, 3D skin bioprinting and the “BioMask” concept in regenerating skin defects - review

1 citations , September 2024 in “Journal of Education Health and Sport”

3D skin bioprinting and "BioMask" offer promising new ways to treat facial skin injuries.

research 626 Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo

April 2021 in “Journal of Investigative Dermatology”

Early-stage skin substitutes improve wound healing and skin structure.

research Tissue-engineered dermal substitutes constructed by human embryonic stem cell-derived fibroblasts facilitate the repair of skin wounds

March 2026 in “Frontiers in Bioengineering and Biotechnology”

Stem cell-derived fibroblasts can effectively repair skin wounds.

research Effect of Cultured Dermal Substitute Composed of Collagen Sponge Seeded with Fibroblasts in Simultaneous Skin Graft Overlay

1 citations , March 2001 in “JOURNAL OF THE KYORIN MEDICAL SOCIETY”

Fibroblast-seeded collagen sponges help skin regrowth but don't improve graft survival.

research Optical Behavior of Human Skin Substitutes: Absorbance in the 200–400 nm UV Range

15 citations , July 2022 in “Biomedicines”

UGRSKIN absorbs UV like native skin after 21-28 days, making it potentially suitable for clinical use.

Early-Stage Bilayer Tissue-Engineered Skin Substitute Formed by Adult Skin Progenitor Cells Produces an Improved Skin Structure In Vivo

research Early-stage bilayer tissue-engineered skin substitute formed by adult skin progenitor cells produces an improved skin structure in vivo

12 citations , September 2020 in “Stem cell research & therapy”

Adult skin cell-based early-stage skin substitutes improve wound healing and hair growth in mice.

research 0873 Modeling junctional epidermolysis bullosa using tissue-engineered skin substitutes

July 2025 in “Journal of Investigative Dermatology”

Tissue-engineered skin substitutes can model junctional epidermolysis bullosa and may help develop gene therapy.

research Reconstruction of Tissue Engineered Skin Substitute Containing Appendages Using Dermal Papillae Cells And Keratinocytes

January 2011 in “Journal of Tissue Engineering and Reconstructive Surgery”

Using dermal papillae cells and keratinocytes in skin substitutes speeds up healing and helps form hair follicles and glands.

Evaluation of Signs of Skin Aging in Patients with Metabolic Syndrome after Substitution Therapy with Antioxidants. Summary of the Doctoral Thesis

research Evaluation of Signs of Skin Aging in Patients with Metabolic Syndrome after Substitution Therapy with Antioxidants. Summary of the Doctoral Thesis

September 2021

Antioxidant therapy, especially with selenium, can improve skin aging in patients with Metabolic Syndrome.

research Growth hormone substitution in adult growth hormone‐deficient men augments androgen effects on the skin

55 citations , July 1997 in “Clinical Endocrinology”

Growth hormone therapy boosts androgen effects on skin in men.

Development of Modified Montmorillonite-Bacterial Cellulose Nanocomposites as a Novel Substitute for Burn Skin and Tissue Regeneration

research Development of modified montmorillonite-bacterial cellulose nanocomposites as a novel substitute for burn skin and tissue regeneration

93 citations , November 2018 in “Carbohydrate Polymers”

New nanocomposites with copper show promise for healing burn wounds and regenerating skin.

Dermal Papilla Cells Improve Wound Healing and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

research Dermal Papilla Cells Improve the Wound Healing Process and Generate Hair Bud-Like Structures in Grafted Skin Substitutes Using Hair Follicle Stem Cells

68 citations , August 2014 in “Stem Cells Translational Medicine”

Dermal papilla cells help wounds heal better and can potentially grow new hair.

research Immunological challenges associated with artificial skin grafts: available solutions and stem cells in future design of synthetic skin

105 citations , December 2017 in “Journal of Biological Engineering”

Artificial skin grafts face immune rejection, but stem cells may improve future designs.

research Epidermal stem cells and skin tissue engineering in hair follicle regeneration

83 citations , January 2015 in “World Journal of Stem Cells”

Hair follicle regeneration needs special conditions and young cells.

research Advanced therapies of skin injuries

28 citations , September 2015 in “Wiener Klinische Wochenschrift”

New skin substitutes for treating severe burns and chronic wounds are being developed, but a permanent solution for deep wounds is not yet available commercially.

Epidermal Stem Cells Cultured on Collagen-Modified Chitin Membrane Induce In Situ Tissue Regeneration of Full-Thickness Skin Defects in Mice

research Epidermal Stem Cells Cultured on Collagen-Modified Chitin Membrane Induce In Situ Tissue Regeneration of Full-Thickness Skin Defects in Mice

28 citations , February 2014 in “PLoS ONE”

Epidermal stem cells on a special membrane helped mice regrow full skin with hair and functions.

Skin Tissue Engineering: Potential of Stem Cell Biology and Skin Morphogenesis

research Skin tissue engineering

12 citations , January 2009 in “Stembook”

Improved understanding of stem cell mechanisms can enhance skin tissue engineering.

research Self Organized Skin Equivalent by Epithelial and Fibroblast Cells on Polycaprolactone Electrospun Mat with Porous Fibers

4 citations , October 2017 in “Advances in tissue engineering & regenerative medicine”

Researchers created a potential skin substitute using a biodegradable mat that supports skin cell growth and layer formation.

research 3D Bioprinting Skin Equivalents: A Methodological Perspective on Human Keratinocyte and Fibroblast Models for Wound Repair and Regeneration

3 citations , June 2025 in “Wound Repair and Regeneration”

3D bioprinting shows promise for creating skin substitutes, but standardized methods are needed for clinical use.

research Skin Graft Harvesting and Donor Site Selection

3 citations , August 2011 in “InTech eBooks”

The document concludes that skin grafts are essential for repairing tissue loss, with various types available and ongoing research into substitutes to improve outcomes and reduce donor site issues.