research Redefining Drug Discovery: A Review of Drug Repurposing –Approaches, Benefits and Breakthroughs
Drug repurposing finds new uses for existing drugs, speeding up treatment availability and reducing costs.
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research Drug repositioning: current approaches and their implications in the precision medicine era
Drug repositioning is becoming more targeted and efficient with new technologies, offering personalized treatment options and growing interest in the field.
research Clinical assessment of CL22209, a standardized proprietary extract of Asparagus racemosus, for mitigating vasomotor and menstrual symptoms in perimenopausal women: A randomized, double-blind, placebo-controlled study
CL22209, an Asparagus racemosus extract, safely reduces perimenopausal symptoms and balances hormones.
research Acquired Localized Hypertrichosis Induced by Rivastigmine
An 80-year-old man grew extra hair on his forearms after starting Alzheimer's medication rivastigmine.
research Repurposing FDA approved drugs for psoriasis indications through integrated molecular docking, one-SVM algorithm, and molecular dynamics simulation approaches
Pioglitazone, Trimipramine, and Dimetindene may be repurposed to treat psoriasis.
research Finasteride
research Finasteride
research Finasteride
research Mesenchymal stem cells and their secretome: a promising approach for Parkinson’s disease treatment
Parkinson's disease (PD) is a debilitating neurodegenerative disorder with increasing prevalence, and current treatments only alleviate symptoms without stopping disease progression. Mesenchymal stem cells (MSCs) offer a promising approach for PD treatment due to their ability to differentiate into dopaminergic neurons and secrete neurotrophic factors, providing neuroprotective effects, promoting remyelination, reducing neural inflammation, and facilitating functional recovery. The therapeutic benefits of MSCs are mainly mediated through paracrine activity, particularly via extracellular vesicles (EVs) and exosomes, which can cross the blood-brain barrier and avoid ethical issues of cell-based therapies. Although the exact mechanisms are not fully understood, MSC-derived exosomes are believed to play a significant role in reparative effects, and bioengineering can enhance their drug delivery and targeting capabilities. This review discusses the potential of MSC and MSC-secretome/EV applications in PD treatment and suggests future research directions.
research High Real-World Medication Adherence and Durable Clinical Benefit in Medicare Patients Treated with 5-Alpha Reductase Inhibitors for Benign Prostatic Hyperplasia
Older patients sticking to their prostate medication saw lasting health benefits.
research Charting the Bromodomain BRD4: Towards the Identification of Novel Inhibitors with Molecular Similarity and Receptor Mapping
Researchers identified promising inhibitors for the BRD4 protein, including finasteride and amentoflavone.
research Preventive and Therapeutic Efficacy of Finasteride and Dutasteride in TRAMP Mice
Dutasteride works better than finasteride for preventing and treating prostate cancer.
research PEGylated Flavonoid Aspasomes as a Brain-Targeted Nano-Vesicular Platform for Enhanced Neuroprotection in Stress-Induced Cognitive Dysfunction
PEGylated flavonoid Aspasomes improve brain protection and memory in stress-related disorders.
research Repurposing of Linagliptin Similar FDA Approved Drugs as Antidiabetic Agents
Pranlukast and mirabegron may work as new diabetes drugs.
research Role of Drug Repurposing in Sustainable Drug Discovery
Drug repurposing speeds up drug development, saves money, and has led to about a third of new drug approvals.
research Effect of the 5α-reductase enzyme inhibitor dutasteride in the brain of intact and parkinsonian mice
Dutasteride may protect the brain in early Parkinson's disease.
research Pramipexole
Pramipexole can cause side effects like dizziness, sleepiness, hallucinations, and low blood pressure, and it's important to educate patients and keep doses low.
research Experimental and theoretical studies on the interaction of finasteride with chitosan-based nanoniosomes
The new finasteride delivery system using chitosan-based nanoniosomes shows promise for prostate cancer prevention.
research Mast cell-5-HT-HTR2A axis involvement in chronic itch induced by SADBE
Targeting the MC-5-HT-HTR2A axis may help treat chronic itching.
research Trazodone by epigenetic mechanism can reverse the post finasteride syndrome
Trazodone might help reverse post finasteride syndrome.
research Editorial Comment
More men are using medication for benign prostatic hyperplasia, influenced by marketing and FDA approvals.
research Overcoming Biological Barriers: A Comprehensive Review of Advanced Melatonin Delivery Systems for Therapeutic Applications
Melatonin, known for its antioxidant and anti-inflammatory properties, faces challenges in clinical use due to poor solubility and low bioavailability. This review explores advanced nanotechnology-based delivery systems designed to overcome these barriers, enhancing melatonin's therapeutic potential for diseases like Alzheimer's, Parkinson's, and various cancers. It highlights the design and formulation of melatonin nanocarriers, emphasizing their ability to bypass physiological barriers and improve drug distribution. The review also discusses the relationship between administration routes and therapeutic outcomes, while addressing challenges in clinical translation, such as manufacturing and regulatory issues, aiming to guide future development of melatonin-based therapies.
research G.P.2.16 Valproate, acetylcarnitine, folic acid and vitamin B12 in spinal muscular atrophy: Preliminary data of an open-label study in children
The treatment with valproate, acetylcarnitine, folic acid, and vitamin B12 may improve muscle strength in children with SMA without significant side effects.
research Biopharmaceutical Performance of DiluCap: A Line of Functional Excipients Enhancing Dissolution Profiles of Minoxidil, Finasteride, Melatonin, and Naltrexone.
DiluCap improves how quickly minoxidil and finasteride dissolve and controls the release of melatonin and naltrexone.
research Smoothened antagonists for hair inhibition
Two new compounds were found to effectively reduce hair growth in mice.
research Repurposed Drugs: Current Trends in Drug Discovery
Drug repurposing speeds up development, cuts costs, and uses known safe drugs, but faces challenges like regulations and patents.
research The preventive and therapeutic efficacy of finasteride and dutasteride in TRAMP mice
Dutasteride showed some prevention of prostate issues but also had limitations, especially with high-grade tumors.
research Targeting of Smoothened for therapeutic gain
Targeting the Smoothened receptor shows promise for treating certain cancers.
research Signal Detection for Adverse Events of Finasteride Using Korea Adverse Event Reporting System (KAERS) Database
research Clinical Study Map- Women's Health Supplement
Personalized supplements are important for women's health, but hormone therapy can increase cancer and heart risks.