72 citations
,
October 1998 in “Baillière's clinical endocrinology and metabolism” Long-term testosterone therapy can cause hormone suppression, affect prostate and heart health, and alter physical characteristics, but does not increase prostate cancer risk and needs more research for full risk assessment.
39 citations
,
January 2019 in “The World Journal of Men's Health” Testosterone replacement therapy can prevent men from fathering children and should not be used by those wanting to stay fertile.
13 citations
,
January 2019 in “Endocrine journal” Dihydrotestosterone treatment can help penis growth in boys with 5α-reductase deficiency but doesn't fully normalize size after puberty.
7 citations
,
January 2009 in “DOAJ (DOAJ: Directory of Open Access Journals)” D-004 did not harm sperm cells in mice.
5 citations
,
December 2012 in “PubMed” Stopping the use of the drug finasteride can improve sperm count and does not prevent normal conception, but caution is advised when trying to conceive.
2 citations
,
December 2017 in “Theriogenology” Testosterone increases acidification in the vas deferens by up-regulating V-ATPase.
2 citations
,
January 2011 in “Yearbook of Urology” Stopping finasteride can improve sperm count in infertile men.
1 citations
,
September 2023 in “Journal of Education Health and Sport” Anabolic-androgenic steroids are dangerous and educating people about their risks is essential.
June 2026 in “The Journal of Sexual Medicine” Finasteride 1 mg reduces semen quality without affecting hormones.
April 2026 in “The Journal of Urology” Finasteride 1 mg/day reduces semen quality without affecting hormones or sexual function.
January 2024 in “Al-Ameed journal for medical research and health sciences” Testosterone is vital for male health, and its deficiency is linked to aging and common health issues.
July 2023 in “The journal of sexual medicine” Anabolic-androgenic steroids harm male hormone levels, sperm, metabolism, and can cause acne, hair loss, and breast growth.
January 2018 in “Elsevier eBooks” 5α-reductase-2 deficiency causes ambiguous genitalia at birth and affects male sexual development, but individuals often develop male characteristics at puberty.
October 1988 in “Pediatric research” Certain maturity signs appear before and after the first release of sperm in boys.
11 citations
,
June 2012 in “Human Reproduction Update” The conclusion is that there is a high demand for new contraceptives that provide both pregnancy prevention and protection against STIs, along with additional health benefits.
April 2026 in “ACS Applied Materials & Interfaces” Sper-12 nanoparticles may help treat hair loss by delivering siRNA to target androgen receptors.
April 2024 in “JCEM case reports” A man's breast enlargement from low-dose finasteride for hair loss didn't go away, even with treatment, and might be more common than reported.
35 citations
,
June 2005 in “The Milbank Quarterly” The conclusion is that formalizing how past decisions influence current health technology assessments could improve the credibility and defense of coverage decisions.
18 citations
,
October 2021 in “Frontiers in Physiology” Lipocalin-Type Prostaglandin D2 Synthase (L-PGDS) is a protein that plays many roles in the body, including sleep regulation, pain management, food intake, and protection against harmful substances. It also affects fat metabolism, glucose intolerance, cell maturation, and is involved in various diseases like diabetes, cancer, and arthritis. It can influence sex organ development and embryonic cell differentiation, and its levels can be used as a diagnostic marker for certain conditions.
5 citations
,
August 1987 in “Andrology” Men with low or no sperm count have lower salivary testosterone levels, and saliva testing can measure their testosterone well.
1 citations
,
September 2020 in “Leonardo” The exhibition made people think about ethics and society in relation to biotech advances.
1 citations
,
January 2002 in “Yaoxue jinzhan” Finasteride reduces sperm count and affects male reproductive function, while Epristeride does not.
September 2008 in “Fertility and Sterility” Greater intimacy leads to better self-reported health in couples having infertility treatment.
5 citations
,
June 2008 in “Acta Cirurgica Brasileira” Finasteride causes sperm production decrease in Mesocricetus auratus.
4 citations
,
January 2023 in “Andrology” The testes produce sperm and hormones essential for male development.
2 citations
,
January 2014 in “Elsevier eBooks” The document explains how sperm cells are produced, the role of testosterone in this process, and how toxins can reduce sperm count and fertility.
April 2025 in “Journal of Skin and Stem Cell” PDRN from trout sperm helps skin and hair regeneration but is costly and complex to produce.
Finasteride significantly reduced sperm production and caused testicular atrophy in hamsters.
4 citations
,
February 2023 in “Stem Cell Research & Therapy” Mouse skin cells can become sperm-like cells in the lab.
Long-term finasteride use may affect sperm structure and chromosomes.