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GlossarySquamous Cell Carcinoma

type of skin cancer originating in outer epidermal cells

Squamous Cell Carcinoma (SCC) is a type of skin cancer that originates in the squamous cells, which are flat cells located in the outer part of the epidermis. It often appears as a red, scaly patch, open sore, or wart-like growth that may crust or bleed. While it can be aggressive and spread to other parts of the body if not treated, it is generally curable when detected early.

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Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

174 citations , November 2016 in “Cell stem cell”

Different types of skin cells have unique genetic markers that affect how likely they are to spread cancer.

research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis

100 citations , May 2006 in “American Journal Of Pathology”

Matriptase is crucial for skin barrier, hair growth, and may contribute to skin cancer.

research YAP and TAZ are essential for basal and squamous cell carcinoma initiation

76 citations , June 2018 in “EMBO Reports”

YAP and TAZ proteins are necessary for the development of two types of skin cancer.

research Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

76 citations , February 2007 in “Cancer Research”

Protein Kinase Cε increases skin sensitivity to UV damage and skin cancer risk.

research Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

65 citations , March 2004 in “Journal of Clinical Investigation”

Inhibiting ornithine decarboxylase may help prevent certain skin cancers.

research Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

64 citations , February 2008 in “Cancer Research”

Inactivating both p53 and Rb genes in mice speeds up aggressive skin cancer development.

research Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

64 citations , March 2004 in “Journal of Clinical Investigation”

Targeting ornithine decarboxylase can help prevent skin cancer.

research The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells

48 citations , April 2021 in “Pharmaceuticals”

Liposomal curcumin improves skin cancer treatment effectiveness while sparing normal cells.

research Keratoacanthoma and other types of squamous cell carcinoma with crateriform architecture: Classification and identification

45 citations , February 2013 in “The Journal of Dermatology”

Keratoacanthoma and some squamous cell carcinomas are linked to hair follicles, while others are not.

research Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2

35 citations , January 2006 in “Cancer Research”

Mice with extra PKCδ resist chemical-induced skin cancer but not UV-induced.

research Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin

34 citations , August 2018 in “Cancer research”

Fixing DNA errors is crucial to prevent skin cancer.

research Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

31 citations , October 2019 in “Genes & Diseases”

Basal cell carcinomas and squamous cell carcinomas have different gene activity patterns, suggesting unique treatment approaches.

research Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶

28 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may increase skin cancer risk by affecting nearby cells.

research Aggressive squamous cell carcinoma developing in a giant epidermal cyst of the abdomen

16 citations , December 2006 in “International Journal of Dermatology”

A woman died from cancer that spread from a long-standing cyst on her abdomen.

research Squamous cell carcinoma arising within folliculitis decalvans

15 citations , May 2008 in “British Journal of Dermatology”

Chronic scalp inflammation can turn into cancer, so regular check-ups are important.

research No Evidence That Human Papillomavirus Is Responsible for the Aggressive Nature of Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous Cell Carcinoma

14 citations , August 2010 in “Journal of Investigative Dermatology”

HPV does not cause aggressive cancer in RDEB patients.

research Connexin 26 (GJB2) mutations in keratitis–ichthyosis–deafness syndrome presenting with squamous cell carcinoma

11 citations , November 2011 in “The Journal of Dermatology”

Connexin-26 gene mutations may increase cancer risk in KID syndrome patients.

Protein Kinase C Epsilon, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

research Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

10 citations , January 2013 in “Journal of skin cancer”

PKC ε increases hair follicle stem cell turnover and may raise skin cancer risk.

research Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma

8 citations , April 2016 in “Experimental Dermatology”

The type of tumor suppressor affects the form of skin cancer from hair follicle stem cells.

RSPO1-Mutated Keratinocytes From Palmoplantar Keratoderma Display Impaired Differentiation and Invasiveness: Implications for Squamous Cell Carcinoma Susceptibility in Patients With 46XX Disorder of Sexual Development

research RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development

5 citations , July 2022 in “Orphanet journal of rare diseases”

RSPO1 mutations in certain patients lead to skin cells that don't develop properly and are more likely to become invasive, increasing the risk of skin cancer.

research A Case of Squamous Cell Carcinoma of the Scalp After Several Synthetic Hair Grafts

5 citations , February 2012 in “Aesthetic Plastic Surgery”

A man developed skin cancer on his scalp after multiple artificial hair grafts.

research Development of squamous cell carcinoma from erythroplasia of Queyrat following photodynamic therapy

3 citations , May 2018 in “European Journal of Dermatology”

Photodynamic therapy may not work for erythroplasia of Queyrat and could lead to invasive squamous cell carcinoma.

research Exploiting the origins of Ras mediated squamous cell carcinoma to develop novel therapeutic interventions

3 citations , November 2011 in “Small GTPases”

Researchers found that hair follicle stem cells can become squamous cell carcinoma due to Ras activation, which could lead to new treatments.

research Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism^¶

3 citations , January 2005 in “Photochemistry and Photobiology”

Protein kinase C epsilon may promote skin cancer development after UV exposure by affecting nearby cells.

Synthetic Hair Implantation and Squamous Cell Carcinoma of the Scalp

research Squamous Cell Carcinoma of the Scalp Following Synthetic Hair Implantation: A Structured Narrative Review and the Seventh Case Reported in Literature

April 2026 in “Cureus”

Synthetic hair implants can cause scalp cancer years later.

research Erosive Pustular Dermatosis of the Scalp Mimicking Squamous Cell Carcinoma: Can Dermoscopy Be Helpful?

April 2025 in “Dermatology Practical & Conceptual”

Biopsy is crucial to accurately distinguish Erosive Pustular Dermatosis of the Scalp from Squamous Cell Carcinoma.

research Erosive Pustular Dermatosis of the Scalp Mimicking Squamous Cell Carcinoma: Can Dermoscopy Be Helpful?

April 2025 in “Dermatology Practical & Conceptual”

Biopsy is crucial for accurately diagnosing EPDS to avoid mistaking it for SCC.

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Related Terms

Research

research Cell-Type-Specific Chromatin States Differentially Prime Squamous Cell Carcinoma Tumor-Initiating Cells for Epithelial to Mesenchymal Transition

research Delineation of Matriptase Protein Expression by Enzymatic Gene Trapping Suggests Diverging Roles in Barrier Function, Hair Formation, and Squamous Cell Carcinogenesis

research YAP and TAZ are essential for basal and squamous cell carcinoma initiation

research Protein Kinase Cε, which Sensitizes Skin to Sun's UV Radiation–Induced Cutaneous Damage and Development of Squamous Cell Carcinomas, Associates with Stat3

research Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

research Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

research Ornithine decarboxylase is a target for chemoprevention of basal and squamous cell carcinomas in Ptch1+/– mice

research The Comparison of In Vitro Photosensitizing Efficacy of Curcumin-Loaded Liposomes Following Photodynamic Therapy on Melanoma MUG-Mel2, Squamous Cell Carcinoma SCC-25, and Normal Keratinocyte HaCaT Cells

research Keratoacanthoma and other types of squamous cell carcinoma with crateriform architecture: Classification and identification

research Protein Kinase C δ Overexpressing Transgenic Mice Are Resistant to Chemically but not to UV Radiation–Induced Development of Squamous Cell Carcinomas: A Possible Link to Specific Cytokines and Cyclooxygenase-2

research Ribonucleotide Excision Repair Is Essential to Prevent Squamous Cell Carcinoma of the Skin

research Distinct transcriptomic landscapes of cutaneous basal cell carcinomas and squamous cell carcinomas

research Protein Kinase C Epsilon Signals Ultraviolet Light-induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism¶

research Aggressive squamous cell carcinoma developing in a giant epidermal cyst of the abdomen

research Squamous cell carcinoma arising within folliculitis decalvans

research No Evidence That Human Papillomavirus Is Responsible for the Aggressive Nature of Recessive Dystrophic Epidermolysis Bullosa–Associated Squamous Cell Carcinoma

research Connexin 26 (GJB2) mutations in keratitis–ichthyosis–deafness syndrome presenting with squamous cell carcinoma

research Protein Kinase Cε, Which Is Linked to Ultraviolet Radiation-Induced Development of Squamous Cell Carcinomas, Stimulates Rapid Turnover of Adult Hair Follicle Stem Cells

research Tumor suppressor identity can contribute to heterogeneity of phenotype in hair follicle stem cell‐induced squamous cell carcinoma

research RSPO1-mutated keratinocytes from palmoplantar keratoderma display impaired differentiation, alteration of cell–cell adhesion, EMT-like phenotype and invasiveness properties: implications for squamous cell carcinoma susceptibility in patients with 46XX disorder of sexual development

research A Case of Squamous Cell Carcinoma of the Scalp After Several Synthetic Hair Grafts

research Development of squamous cell carcinoma from erythroplasia of Queyrat following photodynamic therapy

research Exploiting the origins of Ras mediated squamous cell carcinoma to develop novel therapeutic interventions

research Protein Kinase C Epsilon Signals Ultraviolet Light‐induced Cutaneous Damage and Development of Squamous Cell Carcinoma Possibly Through Induction of Specific Cytokines in a Paracrine Mechanism^¶

research Synthetic Hair Implantation and Squamous Cell Carcinoma of the Scalp

research Horn With Miliary Calcification in Squamous Cell Carcinoma

research Primary Cutaneous Rhabdoid Squamous Cell Carcinoma: A Case Report and Review of Molecular Features

research Squamous Cell Carcinoma of the Scalp Following Synthetic Hair Implantation: A Structured Narrative Review and the Seventh Case Reported in Literature

research Erosive Pustular Dermatosis of the Scalp Mimicking Squamous Cell Carcinoma: Can Dermoscopy Be Helpful?

research Erosive Pustular Dermatosis of the Scalp Mimicking Squamous Cell Carcinoma: Can Dermoscopy Be Helpful?