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GlossarySRD5A3

enzyme involved in converting testosterone to dihydrotestosterone (DHT)

SRD5A3 stands for steroid 5 alpha-reductase 3, an enzyme that plays a crucial role in the conversion of testosterone to dihydrotestosterone (DHT), a more potent androgen. This enzyme is also involved in the biosynthesis of dolichol, which is essential for protein glycosylation, a process important for proper cellular function. Mutations in the SRD5A3 gene can lead to congenital disorders such as SRD5A3-CDG (Congenital Disorder of Glycosylation).

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research SRD5A3 Is Required for Converting Polyprenol to Dolichol and Is Mutated in a Congenital Glycosylation Disorder

260 citations , July 2010 in “Cell”

Mutations in the SRD5A3 gene cause a new type of glycosylation disorder by blocking the production of a molecule necessary for protein glycosylation.

Selected Variants of the Steroid-5-Alpha-Reductase Isoforms SRD5A1 and SRD5A2 and the Sex Steroid Hormone Receptors ESR1, ESR2, and PGR: No Association with Female Pattern Hair Loss Identified

research Selected variants of the steroid-5-alpha-reductase isoforms SRD5A1 and SRD5A2 and the sex steroid hormone receptors ESR1, ESR2 and PGR: No association with female pattern hair loss identified

18 citations , February 2012 in “Experimental Dermatology”

No link found between specific genes and female pattern hair loss.

research Effects on Steroid 5-Alpha Reductase Gene Expression of Thai Rice Bran Extracts and Molecular Dynamics Study on SRD5A2

14 citations , April 2021 in “Biology”

Thai rice bran extracts, especially from Tubtim Chumphae rice, can significantly reduce the activity of hair loss genes, with x-tocopherol showing potential as an anti-hair loss product.

research 5α-reduction of epitestosterone is catalysed by human SRD5A1 and SRD5A2 and increases androgen receptor transactivation

14 citations , April 2024 in “The Journal of Steroid Biochemistry and Molecular Biology”

5α-reductases increase epitestosterone's effect on androgen receptors.

In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus Racemosus Root as Anti-Sebum and Pore-Minimizing Active Ingredients

research In Vitro and In Vivo Regulation of SRD5A mRNA Expression of Supercritical Carbon Dioxide Extract from Asparagus racemosus Willd. Root as Anti-Sebum and Pore-Minimizing Active Ingredients

8 citations , February 2022 in “Molecules”

Asparagus racemosus root extract reduced sebum and pore size in men but not in women.

research Longer TA repeat but not V89L polymorphisms in the SRD5A2 gene may confer acne risk in the Chinese population

3 citations , January 2018 in “Postępy Dermatologii i Alergologii”

Longer TA repeats in the SRD5A2 gene may increase acne risk in Chinese people.

research Exploring the clinical implications of novel SRD5A2 variants in 46,XY disorders of sex development

2 citations , September 2024 in “Asian Journal of Andrology”

New SRD5A2 variants may disrupt protein function, aiding diagnosis and treatment of related disorders.

research Crystal structure of steroid reductase SRD5A reveals conserved steroid reduction mechanism

July 2020 in “bioRxiv (Cold Spring Harbor Laboratory)”

The structure of SRD5A reveals how it reduces steroids, aiding drug design for related health conditions.

research Identification of xenobiotics interfering with 5 α -reductase (SRD5A2) activity

February 2026 in “Toxicology Letters”

MK-0773 is a moderate inhibitor of the SRD5A2 enzyme.

research SRD5A2 and emerging therapies in androgen-driven disorders

January 2026 in “Nature Reviews Urology”

Cloning, Computational Analysis and Expression Profiling of Steroid 5 Alpha-Reductase 1 (SRD5A1) Gene During Reproductive Phases and Ovatide Stimulation in Endangered Catfish, Clarias Magur

research Cloning, computational analysis and expression profiling of steroid 5 alpha-reductase 1 (SRD5A1) gene during reproductive phases and ovatide stimulation in endangered catfish, Clarias magur

November 2023 in “Scientific reports”

The research identified and described a gene important for hormone conversion in endangered catfish, which varies in activity during different reproductive stages and after hormone treatment.

HPLC Profiling and In Silico Studies of Chochurus Olitoris (Jute) Leaf Fractions Against Steroid 5α-Reductase 2 (SRD5α2)

research HPLC Profiling and Insilco studies of Chochurus olitoris (Jute) Leave Fractions against Steroid 5α-Reductase 2 (SRD5α2)

August 2024 in “Biomedical Journal of Scientific & Technical Research”

Jute leaves may help reduce DHT levels, potentially aiding in conditions like hair loss and prostate issues.

research MP09-17 METHYLATION OF SRD5A2 IN THE BLOOD AS A NOVEL BIOMARKER TO PREDICT SENSITIVITY TO 5-ARI TREATMENT

April 2024 in “The Journal of urology/The journal of urology”

SRD5A2 methylation in blood can predict how well someone will respond to finasteride treatment.

Bioactive Metabolites of Edible Mushrooms Efficacious Against Androgenic Alopecia: Targeting SRD5A2 Using Computational Approach

research Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach

November 2022 in “Journal of Herbal Medicine”

Certain compounds found in edible mushrooms may help treat hair loss.

research Bioactive metabolites of edible mushrooms efficacious against androgenic alopecia: Targeting SRD5A2 using computational approach

March 2022 in “Research Square (Research Square)”

Mushroom compounds may help treat hair loss better than Finasteride.

research PD02-05 SRD5A2 EXPRESSION IS A PREDICTOR OF RESPONSE TO FINASTERIDE IN THE MTOPS TRIAL

March 2023 in “The Journal of Urology”

Higher SRD5A2 expression predicts better response to finasteride in treating urinary symptoms.

research Genetic Analysis of Male Pattern Baldness and the 5α-Reductase Genes

169 citations , June 1998 in “Journal of Investigative Dermatology”

Male pattern baldness is likely caused by multiple genes, not just 5α-reductase genes.

research Molecular epidemiology of hypospadias: Review of genetic and environmental risk factors

103 citations , October 2003 in “Birth Defects Research”

Both genes and environmental factors like chemicals may contribute to the increase in hypospadias, but the exact causes are still unclear.

research Steroidogenesis of the testis – new genes and pathways

70 citations , April 2014 in “Annales d'endocrinologie”

New genes and pathways are important for testosterone production and male sexual development.

research Steroidogenesis inhibitors alter but do not eliminate androgen synthesis mechanisms during progression to castration-resistance in LNCaP prostate xenografts

57 citations , April 2009 in “The Journal of Steroid Biochemistry and Molecular Biology”

Steroidogenesis inhibitors change but don't stop androgen production in prostate cancer.

research 5α-Reductase type 2 gene variant associations with prostate cancer risk, circulating hormone levels and androgenetic alopecia

57 citations , November 2006 in “International Journal of Cancer”

A49T gene variant linked to higher prostate cancer risk, lower hormone levels, and slightly reduced balding risk.

research 5α-Reductase Type 2 Regulates Glucocorticoid Action and Metabolic Phenotype in Human Hepatocytes

54 citations , May 2015 in “Endocrinology”

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

research The slick hair coat locus maps to chromosome 20 in Senepol-derived cattle

51 citations , January 2007 in “Animal Genetics”

The gene for slick hair in Senepol cattle is located on chromosome 20 and may involve the SRD5A2 gene.

research Ultrasound-activated particles as CRISPR/Cas9 delivery system for androgenic alopecia therapy

47 citations , December 2019 in “Biomaterials”

Scientists have created a new hair loss treatment using ultrasound to deliver gene-editing particles, which resulted in up to 90% hair regrowth in mice.

research 5α-Reduced glucocorticoids: a story of natural selection

46 citations , September 2011 in “Journal of Endocrinology”

Natural 5α-reduced glucocorticoids might be anti-inflammatory with fewer side effects than current options.

5-Alpha-Reductase Type 2 Deficiency: Is There a Genotype-Phenotype Correlation? A Review

research 5-α-Reductase type 2 deficiency: is there a genotype-phenotype correlation? A review

39 citations , April 2018 in “Hormones”

No consistent link between genotype and phenotype in 5-α-Reductase type 2 deficiency.

research Sex dependent influence of a functional polymorphism in steroid 5‐α‐reductase type 2 (SRD5A2) on post‐traumatic stress symptoms

35 citations , March 2013 in “American Journal of Medical Genetics Part B Neuropsychiatric Genetics”

SRD5A2 gene variations affect PTSD symptoms differently in males and females.

research Differential expression of steroid 5α-reductase isozymes and association with disease severity and angiogenic genes predict their biological role in prostate cancer

30 citations , June 2010 in “Endocrine Related Cancer”

SRD5A1 is crucial in advanced prostate cancer, and blocking both SRD5A1 and SRD5A2 is more effective than targeting SRD5A2 alone.

research Structure of human steroid 5α-reductase 2 with the anti-androgen drug finasteride

30 citations , October 2020 in “Nature Communications”

Finasteride irreversibly affects human steroid 5α-reductase 2, providing insight into its catalytic mechanism and disease-related mutations.

research Rare and common genetic determinants of metabolic individuality and their effects on human health

29 citations , November 2022 in “Nature Medicine”

Genetic variations greatly affect individual metabolism and can impact health and disease risk.