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Some patients may experience lasting sexual dysfunction, depression, and other side effects from 5α-reductase inhibitor therapy.

Finasteride may cause depression and affect brain and gut health in male rats.

Isotretinoin can cause gynecomastia by lowering testosterone levels.

Using hair loss drugs finasteride and dutasteride may cause sexual side effects.

Men taking 5α-reductase inhibitors for enlarged prostate have a higher chance of experiencing reduced sexual desire and erectile dysfunction.

Spironolactone improved cognitive performance and early sleep quality but not manic symptoms, appetite, or body weight in bipolar disorder when added to sodium valproate.

BPH medications may increase the risk of self-harm and depression, especially in the first 18 months.

Finasteride worsens stress effects on sensory processes, possibly linking to anxiety/depression.

Post-finasteride patients show changed neuroactive steroid levels, possibly causing erectile dysfunction and depression.

Finasteride may increase depression and suicide risks, needing better safety checks and informed consent.

Finasteride is not proven to cause depression or suicide, and careful patient monitoring is advised.

Finasteride use linked to increased suicidality in patients under 45.

Finasteride significantly reduced tics and obsessive-compulsive symptoms in Tourette syndrome patients.

Finasteride can cause depression and suicidal thoughts; safer alternatives are recommended.

5α-reduced neurosteroids may help regulate glial cell differentiation.

Mirtazapine may cause hair loss and change hair color, but stopping the drug can reverse these effects.

Finasteride may affect mood and increase suicidal risk.

Finasteride use can cause depression-like behavior in male rats.

Urologists should monitor mental health in patients taking finasteride due to potential links to suicidal thoughts, adjusting dosage or stopping use if necessary. More research is needed to confirm if finasteride causes these thoughts.

Oral spironolactone and isotretinoin are effective for treating acne.

Finasteride may help reduce symptoms in male Tourette syndrome patients.