research Finasteride inhibits melanogenesis through regulation of the adenylate cyclase in melanocytes and melanoma cells
Finasteride reduces melanin production, possibly treating hyperpigmentation and melanoma, but needs more safety research.
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240-270 / 1000+ results research Intradermal platelet-rich plasma for the treatment of melasma: A clinical and dermoscopic evaluation in dark skin
Intradermal PRP significantly improved melasma in dark skin, with lasting results and no relapse after 3 months.
research Logic-based modeling and drug repurposing for the prediction of novel therapeutic targets and combination regimens against E2F1-driven melanoma progression
Tadalafil and Finasteride may help treat aggressive melanoma.
research Hyperpigmentation and Melasma
Hyperpigmentation is common in pregnancy and may not fully fade after birth; melasma, also frequent, can persist but has limited treatment options during pregnancy.
research Mitoxantrone
Mitoxantrone with a corticosteroid helps manage symptoms for some advanced prostate cancer patients but doesn't extend life.
research Efficacy and Safety of Platelet-Rich Plasma in Melasma: A Systematic Review
Platelet-rich plasma (PRP) shows promise for treating melasma but needs more research for confirmation.
research Co-delivery of Minoxidil and Tocopherol acetate Ethosomes to Reshape the Hair FolliculaMicroenvironment and Promote Hair Regeneration in Androgenetic Alopecia
Using minoxidil with tocopherol acetate in ethosomes improves hair regrowth in hair loss treatment.
research Finasteride Inhibits Melanogenesis throughthe Regulation of Melanocortin 1 Receptorin Melanocytes
Finasteride reduces melanin production in skin cells.
research Stimulation of melanogenesis by Carthamus tinctorius floret extract in B16F10 murine melanoma cells
Safflower extract increases melanin production in certain skin cells without harming them.
research Μορφοποίηση παραγόντων κατά της τριχόπτωσης σε νέους καλλυντικοτεχνικούς φορείς και εκτίμηση της δράσης αυτών
Liposomes with minoxidil and PEP penetrate skin slowly but reach deeper layers than foam.
research Glycine Inhibits Melanogenesis in Vitro and Causes Hypopigmentation in Vivo
Glycine reduces skin pigmentation by lowering melanin production.
research Topical application of dehydroxymethylepoxyquinomicin improves allergic inflammation via NF-κB inhibition
A new cream, DHMEQ, reduces allergic skin inflammation effectively.
research The antimycotic agent clotrimazole inhibits melanogenesis by accelerating ERK and PI3K-/Akt-mediated tyrosinase degradation
Clotrimazole, an antifungal cream, may safely reduce skin pigmentation by breaking down the enzyme needed for making melanin.
research Epidermal cell proliferation and modulation of the protective potency of dexamethasone against phorbol ester-induced ornithine decarboxylase activity
Dexamethasone reduces inflammation and delays skin cell changes caused by TPA.
research When the Circadian Clock Meets the Melanin Pigmentary System
Silencing certain circadian clock genes increases skin pigmentation.
research Comparison of Effects on Gene Expression Activity of Low-Molecular-Weight Lychee Fruit Polyphenol (Oligonol®), Adenosine, and Minoxidil in Human Dermal Papilla Cells
Lychee fruit polyphenol (Oligonol®) may regulate genes linked to cell growth and inflammation in human scalp cells.
research Epimedium brevicornum Maxim. Extract exhibits pigmentation by melanin biosynthesis and melanosome biogenesis/transfer
Epimedium extract helps increase skin pigmentation and could be a new treatment for conditions with reduced pigmentation.
research Microneedling kombinasi minoksidil 5% dengan steroid sistemik dan topikal pada pasien alopesia areata: laporan kasus
The combination therapy improved severe alopecia areata in a patient after 14 days.
research Preparation and evaluation of a multimodal minoxidil microemulsion versus minoxidil alone in the treatment of androgenic alopecia of mixed etiology: a pilot study
The multimodal microemulsion with minoxidil, diclofenac, and tea tree oil is more effective for hair growth than minoxidil alone.
research Clobetasol/minoxidil
research Analysis of changes in microRNA expression profiles in response to the troxerutin-mediated antioxidant effect in human dermal papilla cells
Troxerutin helps protect skin cells from oxidative stress and may be good for treating hair loss.
research Dual deficiency of melatonin and dihydrotestosterone promotes stromal cell damage and mediates prostatitis via the cGAS-STING pathway in sleep-deprived mice
Lack of sleep in mice leads to prostatitis by reducing certain hormones and activating an inflammatory pathway, which can be temporarily fixed with normal sleep.
research Impact of Formulation Variables on Meloxicam spanlastics Preparation
Spanlastics are effective for delivering Meloxicam with improved stability and targeting.
research Plant‐Derived Monomers for Grey Hair Reversal Through Upregulation of Melanogenesis and Tyrosinase Activity
Plant-derived compounds may help reverse grey hair by boosting melanin production.
research Effects of molybdenum on growth and fruit quality of small fruit melon (Cucumis melo L.) cultivated under high-temperature stress
Using 0.1 mg·L–1 molybdenum improves melon growth, quality, and yield under high heat.
research Clinical Snippets
Increased pigmentation may protect skin from UVB, new targets for skin disease treatments were identified, sunscreen ingredients don't affect hormones, TNF-α inhibitors may help diabetic wounds, and certain treatments could prevent chemotherapy-induced hair loss.
research Antroquinonol Exerts Immunosuppressive Effect on CD8+ T Cell Proliferation and Activation to Resist Depigmentation Induced by H2O2
Antroquinonol may help prevent skin depigmentation by suppressing certain immune cells.
research Melatonin promotes proliferation of Inner Mongolia cashmere goat hair follicle papilla cells through Wnt10b
Melatonin helps grow cashmere goat hair by activating the Wnt10b gene.
research Temperature-dependent phase transition microemulsions for enhanced transdermal delivery of finasteride and silodosin
Menthol-based microemulsions improve skin delivery of finasteride and silodosin.
research Investigation on the Effect of 7% Chamomile Extract on Cutaneous Side Effects of Minoxidil in Treatment of Male Androgenetic Alopecia
Adding 7% chamomile extract to minoxidil reduces skin side effects in treating male hair loss.