Search

everythinglearnresearchcommunity

for

Search:↓

Alcoholic solvent improves selectivity in key intermediate for finasteride and dutasteride synthesis.

Adding cerium(III) chloride to Grignard reagents improves the making of compounds that could treat prostate issues and hair loss.

A new method efficiently creates biaryl N-oxides with potential for cancer treatment and drug development.

The document reviews 20 U.S. patents from July and August 2004 about new drug forms, cancer treatments, aroma chemicals, statin drugs, and various chemical production methods.

Mutants of CYP154C2 enzyme significantly improved steroid conversion efficiency.

Researchers made two new compounds that could be used for medicine.

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

CYP154C7 enzyme can effectively modify steroids and is promising for commercial use.

Potassium channel openers could help treat cardiovascular diseases and asthma but require better targeting to specific tissues for effective use.

New LPA receptors (LPA4, LPA5, LPA6) have diverse roles in the body.

Selective non-steroidal inhibitors of 5α-reductase type 1 can help treat DHT-related disorders.

Neuroactive steroids show promise for treating mental and neurological disorders by targeting GABA_A receptors.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

New research is needed to create better drugs that block the enzyme responsible for conditions like male baldness and prostate enlargement.

A new compound was made that might help treat diseases related to male hormones.

Scientists improved an enzyme to better produce a hair growth-promoting chemical from an immunosuppressant.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

Modified steroidal inhibitors showed promise in treating hormone-dependent cancers.

Scientists made all eight versions of a compound called cyoctol, but found it's not an anti-androgen and it fully breaks down in the skin.

Using β-cyclodextrin derivatives improves the solubility and bioavailability of steroidal drugs.

A substance called Compound 2g can strongly block STS (a hormone-related enzyme) without affecting estrogen levels, making it potentially good for treating breast cancer.

Optimizing the structure of a specific compound greatly improved its effectiveness and precision for treating diabetic complications.

Finasteride effectively inhibits the enzyme steroid 5 alpha-reductase II.

A new method using solid-state circular dichroism anisotropy can distinguish similar chiral compounds better than traditional techniques.

The more lipophilic the progesterone derivative, the better it binds to androgen receptors and has antiandrogenic effects.

A new method creates unique chemical structures that could improve drug discovery.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

A new, efficient method creates sulfinimidate esters from sulfenamides and alcohols without metals.

New compounds were made that block an enzyme linked to breast cancer better than existing treatments.