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Androgen is important in controlling stem cell differentiation, reducing fat development, and increasing lean mass.

DHT affects bone growth by altering gene activity in osteoblasts, potentially complicating steroid use.

Testosterone affects androgen receptors and lipid storage in cells, while DHEA does not convert to testosterone or affect these receptors in the same way.

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

Steroid-binding globulins have important roles beyond just transporting steroids.

Three specific 4-azasteroid-2-oximes showed strong enzyme inhibition, but less than finasteride.

Steroids affect skin health and healing, offering new treatment options.

New steroids were patented as effective for treating acne, hair loss, and other conditions related to hormones.

Steroid sulfatase is important for activating hormones that affect memory, brain function, and certain diseases, and could be a target for treating hormone-related disorders.

Testosterone and some of its forms can strongly stimulate oil gland growth in skin.

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

Testosterone is important for male sexual traits, reproduction, muscle and bone health, blood production, and metabolism, and works both directly and after being changed into other hormones.

Stiripentol shows promise as a potential treatment for androgen-related diseases but needs more testing.

Androgens affect bone and fat cell development differently based on the cells' embryonic origin.

Sex steroids, especially progesterone, can slow down the growth of mouse melanoma cells.

Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.

Higher androgen levels and site-specific AR expression cause sex-related skeletal differences, and certain steroids can boost AR expression and androgen effects in bone cells.

Bolandiol, a synthetic steroid, builds muscle and bone without greatly affecting sex glands, and works differently from other hormones.

Mice lacking steroid 5α-reductase 2 show less aggression and better impulse control.

A 17-year-old female with adrenogenital syndrome produces very high levels of androgens, which prevent complete feminization despite high estrogen doses.

5α-reductases increase epitestosterone's effect on androgen receptors.

Prostate cells have proteins that bind to specific hormones, which can increase protein production when activated by these hormones.

Diet changes hormone levels in pregnant ewes by affecting metabolism, not placental synthesis.

Women with PCOS have higher 5alpha-reductase activity, affecting steroid levels.

Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.

Steroid sulfatase inhibitors could potentially treat hormone-related disorders like certain cancers, hair loss, acne, and improve cognitive dysfunction.

Male sexual differentiation is regulated independently, while female differentiation occurs in an androgenic environment, affecting conditions like congenital adrenal hyperplasia.

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

Hair follicles and glands significantly increase steroid absorption in skin.