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Different halogens on progesterone derivatives can either block or mimic male hormone effects, depending on their type and amount.

Canine hair follicle cells metabolize DHEA and testosterone differently than human cells.

17β-estradiol can reduce inflammation in the skin.

A rare ovarian tumor can occur without causing male-like symptoms.

Female mice with disrupted 5α-reductase 1 had significant metabolic issues, including stress response problems, insulin resistance, liver fat buildup, and obesity.

Certain compounds reduced hamster flank organ size by inhibiting 5α-reductase, like finasteride, without affecting androgen receptors.

Dexamethasone increases androgen receptor activity in scalp cells, which might explain stress-related hair loss.

ROR-alpha may increase the growth of certain breast cancer cells by boosting aromatase, which could affect breast cancer prognosis.

Low SHBG and high FAI, FT, and DHEAS levels are effective in identifying PCOS.

The animal models successfully simulated dry eye related to sex steroid deficiency.

Enzymes called 5α-reductases have many body functions and need more research to safely use inhibitors.

Beard hair follicles convert testosterone to 5α-dihydrotestosterone most intensively.

Neuroactive steroids affect cocaine's rewarding effects through the ς₁ receptor.

A rare ovarian tumor caused high male hormone levels, but surgery fixed it.

Isoproterenol may help treat hair loss by activating hair follicle stem cells.

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

17β-estradiol lowers polyamine oxidase levels in breast cancer cells through estrogen receptor 2.

Testosterone needs to be converted to DHT to reduce stress response in male rats.

The method can measure multiple steroids in human hair to study long-term steroid metabolism, especially in newborns and children.

Steroid cell tumors in the ovary are rare, can produce testosterone causing symptoms, and are mainly treated with surgery.

DHT deficiency may disrupt rat epididymis function by affecting estrogen receptors.

Different species and human skin models vary in their skin enzyme activities, with pig skin and some models closely matching human skin, useful for safety assessments and understanding the skin's protective roles.

Certain substances can decrease or increase exploratory behavior in rodents.

Canine hair follicle cells convert progesterone into various metabolites, mainly cortisol.

The chemicals 17βC and its methyl ester can block the effects of testosterone on hamster skin but not the effects of DHT.

Some prostate cancers have gene changes that may affect treatment with certain drugs.

Sex hormones may be linked to inflammation in Hidradenitis Suppurativa.

Hepatitis B virus alters steroid hormones in male mice, reducing dihydrotestosterone to inhibit viral replication.

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.