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The research gives new understanding on how human steroid 5α-reductases work and how drugs like finasteride inhibit them, which could help in creating new drugs.

Torilin from Torilis japonica can inhibit testosterone 5α-reductase but is less effective than finasteride.

Some gonadal hormone drugs can block filovirus entry into cells.

Neurosteroids help control dopamine responses in the brain.

Plant steroid hormones show growth, health, and medicinal benefits in various organisms, including potential for treating diseases.

A new compound with strong antiandrogenic effects was found, potentially useful for treating conditions like acne and prostate cancer.

New compounds were made and tested, with compound 6 showing potential for treating prostate-related diseases.

5α-reductase inhibitors, like Finasteride and Dutasteride, help manage benign prostatic hyperplasia.

Finasteride, a drug, can block the seizure-preventing effects of a hormone called progesterone in mice.

Researchers developed new compounds that target the androgen receptor effectively with fewer side effects.

Progesterone reduces spinal reflex activity by increasing certain GABA(A) receptor subtypes.

New pregnane derivatives are effective at inhibiting an enzyme linked to hair loss and reducing oil gland activity.

5α-reductase inhibitors help treat disorders caused by DHT and have potential for future therapies.

Human bone cells mainly produce a type 1 enzyme that may help regulate bone health.

New A-homo-B, 19-dinor steroids showed strong antiandrogenic activity without affecting the enzyme 5α-reductase or androgen receptor binding.

Blocking 11β-HSD1 reduces stress hormone damage in hair growth cells.

β-sitosterol and brassicasterol may help treat hair loss.

This enzyme helps metabolize fatty acids and isoleucine, and could be key in treating neurological diseases and certain cancers.

Finasteride blocks deoxycorticosterone's anticonvulsant effects in infant rats, but indomethacin doesn't.

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

LX-38 is a safer drug option for hair loss and prostate issues without hormonal side effects.

Two new compounds can block androgen receptor activity in different ways and may lead to new treatments for androgen-related diseases.

Finasteride helps treat hair loss and prostate enlargement by blocking a specific enzyme.

SARMs show promise but need more evidence to prove they're better than traditional androgens.

5α-reductase inhibitors can interfere with doping tests by masking banned substances.

Antiandrogens affect androgen-dependent body functions and are used for various medical conditions, with some risks like fetus feminization, but new forms like 17α-propylmesterolone show promise for acne without systemic effects.

LX-38 is a safer drug option for treating prostate issues and hair loss without hormonal side effects.

Potential new drugs for treating PCOS were identified.

Manipulating 5α-reductase type 2 can affect liver fat production and glucocorticoid effects.

5αR inhibitors help slow early prostate cancer cell growth, suggesting combined treatments are needed.