research The significance of CYP11A1 expression in skin physiology and pathology
CYP11A1 is crucial for skin health and disease by producing important steroids.
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660-690 / 1000+ resultsresearch Finasteride/spironolactone
research Natural Product-Inspired Bis(trifluoromethyl) Phenyl Hydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitors of Human Steroid 5α-Reductase Type-1: Synthesis, In Vitro, and In Silico Studies
New compounds show promise as nonsteroidal treatments for hair loss.
research Determination of rat 5α-reductase type 1 isozyme activity and its inhibition by novel steroidal oxazolines
New steroidal compounds moderately block an enzyme related to testosterone conversion, less effectively than finasteride.
research Involvement of neurosteroids in the anxiolytic-like effects of AC-5216 in mice
AC-5216 reduces anxiety in mice through neurosteroids affecting GABAA receptors.
research 13-cis-Retinoic Acid Affects Sheath-Shaft Interactions of Equine Hair Follicles in Vitro
research 17-Oximino-5-androsten-3β-yl esters: synthesis, antiproliferative activity, acute toxicity, and effect on serum androgen level
Some synthesized compounds were more effective than Finasteride in reducing prostate cancer cell growth and androgen levels.
research Recent Advances in Multiple Strategies for the Biosynthesis of Sesquiterpenols
Synthetic biology can improve sesquiterpenol production by using innovative microbial strategies.
research Ceramide synthase 4 is involved in the regulation of hair follicle stem cell homeostasis
research A New Strategy for Consumption of Functional Lipids from Ericerus pela (Chavannes): Study on Microcapsules and Effervescent Tablets Containing Insect Wax–Derived Policosanol
Microcapsules and effervescent tablets make insect lipids easier to consume.
research Trichocyte Keratin-Associated Proteins (KAPs)
research Pre-keratin isolated from epidermal microsomes
research Dehydroepiandrosterone- and glucose-6-phosphate-dehydrogenases in the hair cycle of the rat
research Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry
Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.
research Progestogens with Antiandrogenic Properties
research Evaluation of an eucalyptus oil containing topical drug delivery system for selected steroid hormones
The eucalyptus oil system improved skin delivery of hormones, but safety concerns remain.
research Neurosteroids Are Endogenous Neuroprotectants in an Ex Vivo Glaucoma Model
A natural steroid in the body may protect against eye damage in glaucoma.
research Neurosteroids, neuroactive steroids, and symptoms of affective disorders
Certain steroids in the brain affect mood and symptoms of depression, and treatments targeting these steroids show promise for improving these symptoms.
research Attenuation of 5α-reductase-mediated progesterone metabolism promotes differentiation of human endometrial stromal cells for the establishment of pregnancy
Reducing 5α-reductase activity helps endometrial cells differentiate, aiding pregnancy.
research Synthesis of mimics of steroid A ring as potential enzyme inhibitors
Mimicking the steroid A-ring may help create effective enzyme inhibitors for prostate disease treatment.
research Binding of Steroid Hormones by the 105,000 x g Supernatant Fraction from Homogenates of Rat Skin and Variations during the Hair Cycle
Steroid hormone binding in rat skin varies with pH, heat, and hair cycle phases.
research Effect of perfluorooctanesulfonate exposure on steroid hormone levels and steroidogenic enzyme activities in juvenile Silurana tropicalis
PFOS exposure disrupts hormone levels and enzyme activities in juvenile frogs, affecting males and females differently.
research Statins for women with polycystic ovary syndrome not actively trying to conceive
The effectiveness of statins for women with PCOS is unclear.
research Crystal Structure and Synthesis of 17α-Hexanoyloxy-16β-methylpregna-4,6-diene-3,20-dione
A new compound that could treat various androgen-related conditions was created and analyzed.
research Serums and Hair Styling Products
research Deletion of the Sox21 gene drastically affects hair lipids
Deleting the Sox21 gene changes hair lipid composition and increases cholesterol sulfate levels.
research ENHANCEMENT OF FOLLICULAR DELIVERY OF FINASTERIDE IN NIOSOMALAND PRONIOSOMAL GEL FORM FOR TREATING ANDROGENETIC ALOPECIA
Finasteride, a hair loss treatment, works better and is more stable when delivered through specially prepared gels, leading to increased hair growth.
research Activity of steroid 4 and derivatives 4a–4f as inhibitors of the enzyme 5α-reductase 1
Compounds 4, 4b, and 4c effectively inhibit an enzyme linked to testosterone conversion without significant toxicity.
research Possible involvement of 5α-reduced neurosteroids in adrenergic and serotonergic stimulation of GFAP gene expression in rat C6 glioma cells
5α-reduced neurosteroids may help regulate glial cell differentiation.
research 정상 및 배양 피부 , 수종 각화이상성 피부질환에서의 Skin Sulfhydryl Oxidase 발현에 관한 연구
SSO helps in skin protection and keratinization.