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The study examined 153 women with alopecia to explore the relationship between the condition's genesis, mental maladaptation, and psychoemotional disturbances. It found that women with mixed alopecia exhibited significantly higher levels of depression, anxiety, and stress compared to those with metabolic alopecia. The severity of these emotional disturbances was closely linked to the level of mental maladaptation, with anxiety being the most prevalent symptom. The findings highlight the importance of a comprehensive medical and psychological approach, grounded in the biopsychosocial model, to address the emotional challenges faced by women with alopecia.

This study investigates the degradation profile of finasteride, a drug used for benign prostatic hyperplasia and androgenetic alopecia, under stress conditions. Using LC–MS, three degradation products were identified under acidic conditions, with minimal degradation in alkaline and oxidative environments. The degradation products were isolated and analyzed using preparative HPLC, HRMS, and NMR spectroscopy. The study revealed that the degradation process of DP-1 involved cleavage of the tert-butyl amide and addition of water across the alkene moiety. The structure of DP-1 was established through various spectroscopic techniques, and it, along with other degradation products, was found to be previously undescribed. These findings enhance the understanding of finasteride's degradation chemistry, aiding impurity profiling, stability studies, and quality control of its formulations.