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Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

research Synthesis and Structure–Activity Relationships of the First Ferrocenyl-Aryl-Hydantoin Derivatives of the Nonsteroidal Antiandrogen Nilutamide

88 citations , February 2008 in “Journal of Medicinal Chemistry”

Scientists made the first metal-based compounds from a nonsteroidal antiandrogen drug, which showed potential in fighting both hormone-dependent and independent prostate cancer cells.

Synthesis and Structure–Activity Studies of Side-Chain Derivatized Arylhydantoins for Investigation as Androgen Receptor Radioligands

research Synthesis and structure–activity studies of side-chain derivatized arylhydantoins for investigation as androgen receptor radioligands

18 citations , April 2001 in “Bioorganic & Medicinal Chemistry Letters”

The nature of the side chain in RU 58841 derivatives greatly affects its AR affinity, with the N-(iodopropenyl) derivative 13 showing the highest AR binding affinity, suggesting its potential for developing high-affinity radioiodinated AR radioligands.

research 842Combination therapy with rofecoxib and finasteride in the treatment of men with lower urinary tract symptoms (LUTS)

March 2005 in “European Urology Supplements”

research 471 Senolytic Potential of Fisetin and ABT Compounds in Dermal Fibroblasts

November 2025 in “Journal of Investigative Dermatology”

research WS PRO 160 I 120 mg (a combination of sabal and urtica extract) in patients with LUTS related to BPH

3 citations , January 2019 in “Therapeutic advances in urology”

WS PRO 160 I 120 mg effectively treats urinary symptoms from BPH with good safety and tolerability.

research Synthetic studies toward the development of novel minoxidil analogs and conjugates with polyamines

12 citations , February 2010 in “Tetrahedron Letters”

New minoxidil compounds with better water solubility were made, but their full effects and safety need more research.

research Atroposelective Synthesis of Biaryl N‐Oxides via Cu‐Catalyzed De Novo Heteroaromatic N‐Oxide Ring Formation

6 citations , August 2024 in “Advanced Science”

A new method efficiently creates biaryl N-oxides with potential for cancer treatment and drug development.

Modern Approaches to the Use of Emulsifiers and Preservatives in Dermatological Medicines

research СУЧАСНІ ПІДХОДИ ДО ЗАСТОСУВАННЯ ЕМУЛЬГАТОРІВ ТА КОНСЕРВАНТІВ У СКЛАДІ ДЕРМАТОЛОГІЧНИХ ЛІКАРСЬКИХ ЗАСОБІВ

3 citations , October 2018 in “Фармацевтичний часопис”

Biogenic surfactants should be explored as safer alternatives in dermatological products.

research Arginosuccinicaciduria

10 citations , May 1974 in “American journal of diseases of children”

The girl had a rare disorder causing mental and physical symptoms, with weak hair and unclear neurological issues.

research Дослідження ПРОСПЕКТ IV (ПРОСтамол: ПЕрспективи Комбінованої Терапії) у хворих на доброякісну гіперплазію передміхурової залози

September 2020 in “Scientific periodicals of Ukraine”

"Flosin – Prostamol Uno" effectively manages BPH symptoms with fewer side effects.

research Efficacy and Safety of Treatment with Combine Mycophenolate Mofetil and Corticosteroid for Lupus Nephritis:A Multicenter Open-label Study

January 2008 in “Zhonghua linchuang mianyi he biantai fanying zazhi”

The treatment with Shunyou and prednisone is effective and safe for lupus nephritis.

research Efficacy and Safety of SER120 Nasal Spray in Patients with Nocturia: Pooled Analysis of 2 Randomized, Double-Blind, Placebo Controlled, Phase 3 Trials

21 citations , April 2018 in “The Journal of urology/The journal of urology”

SER120 nasal spray effectively reduces nighttime urination and is safe for patients.

The Use of Ultrasound-Targeted Microbubble Destruction Technology for Drug Delivery and Gene Transfection in the Treatment of Atherosclerosis

research 13777 The off-label use of spironolactone in female pattern hair loss

1 citations , November 2020 in “Journal of The American Academy of Dermatology”

GSK-36 downregulation with UTMD improves plaque stability in atherosclerosis treatment.

research Dual inhibitors of urease and carbonic anhydrase-II from Iris species

8 citations , July 2019 in “Pure and Applied Chemistry”

Some natural compounds from Iris plants can block enzymes related to certain disorders, with a few affecting both targeted enzymes.

$Synthesis and Structural Characterization of a New Dinuclear Platinum(III) Complex, [Pt2Cl4(NH3)2{μ-HN=C(O)Bu^t}2]$

research Synthesis and structural characterization of a new dinuclear platinum(III) complex, [Pt₂Cl₄(NH₃)₂{μ-HN=C(O)Bu^t}₂]

2 citations , November 2022 in “Acta crystallographica. Section B, Structural science, crystal engineering and materials./Acta crystallographica. Section B, Structural science, crystal engineering and materials”

A new platinum complex was made and studied, which might help fight cancer better.

research The synthesis of (−)-4-methyl-8-chloro-trans-1,2,3,4,4a,5,6,10b-octahydrobenzo-[f]-quinolin-3-one-[3-14C] (LY300502-14C]) via a circuitous route

3 citations , October 1994 in “Journal of Labelled Compounds and Radiopharmaceuticals”

Scientists made a carbon-14 labeled version of a drug with a 48% yield and over 99% purity.

Sulphation Catalyzed by the Human Cytosolic Sulphotransferases: Chemical Defense or Molecular Terrorism?

research Sulphation catalysed by the human cytosolic sulphotransferases - chemical defence or molecular terrorism?

48 citations , July 1996 in “Human & Experimental Toxicology”

Human enzymes can detoxify harmful substances but might also increase their cancer risk.

research Synthesis, Biological Evaluation and in silico Studies of Novel 5α-aza-Bhomo-3,5-secosteroids as Potential 5-reductase Inhibitors

October 2016 in “Letters in Drug Design & Discovery”

Response Surface Methodology Approach to Formulate and Optimize the Bilayer Combination Tablet of Tamsulosin and Finasteride

research Response Surface Methodology (RSM) approach to formulate and optimize the bilayer combination tablet of Tamsulosin and Finasteride

January 2024 in “Saudi pharmaceutical journal”

The study successfully formulated and optimized a bilayer tablet combining Tamsulosin and Finasteride using response surface methodology.

research When two plus two must not equal four

June 2011 in “British Journal of Urology”

Regulatory challenges make developing combination therapies in urology difficult and costly.

Steroid Sulfatase Inhibitors: Therapeutic Applications and Development

research Steroid sulfatase inhibitors

25 citations , May 2003 in “Expert Opinion on Therapeutic Patents”

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.