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The NUDT15 R139C variant causes thiopurine-induced leukocytopenia through a different mechanism than previously thought in Japanese patients with inflammatory bowel disease.

The enzyme is crucial for skin cell development and can be activated without proteolytic activation.

TSPO might help treat anxiety and depression.

Increasing TSPO in the brain reduces anxiety and depression.

A small change in the TRPS1 gene leads to a less severe form of a syndrome affecting hair, nose, and finger development.

Overexpressing a specific enzyme in mice causes hair loss and female infertility.

Steroid Sulfatase inhibitors show promise in treating hormone-dependent disorders like cancers, hair loss, and acne, with 667COUMATE being a potential candidate for breast cancer treatment trials.

Raltitrexed conjugates are less potent than the free drug but more effective at high concentrations.

Sacituzumab tirumotecan shows promise in treating breast cancer with manageable side effects.

Steroid sulfatase inhibitors could potentially treat hormone-related disorders like certain cancers, hair loss, acne, and improve cognitive dysfunction.

GSH-T levels in hair follicles are similar in smokers and non-smokers and don't increase with certain treatments.

Altering SSAT affects fat metabolism and body fat in mice.

Reconstructed skin models are useful for studying how skin processes certain chemicals.

Compound 1 showed promising anticancer activity.

Sulfur-containing radioprotectors can protect hair from X-ray damage if given before exposure but worsen damage if given after.

Recessive X-linked ichthyosis involves a less efficient enzyme in hair follicles, suggesting two distinct enzymes.

Tebentafusp-tebn improves survival rates in uveal melanoma patients but has common side effects like rash and fatigue.

Leflunomide successfully treated a rare skin condition in a liver transplant patient.

Certain genetic variations are linked to higher liver enzyme levels in patients treated for chronic hepatitis C with specific drugs.

Researchers developed a quick and accurate method to measure finasteride and tamsulosin in tablets.

Superoxide dismutases help balance cell stress and may aid cancer treatment.

Two patients had a unique form of trichothiodystrophy with reduced high-sulfur proteins in their hair.

Sulphadiazine can cause crystals to form in urine.

A new genetic mutation linked to CARASIL syndrome and small artery disease was found in a Chinese family.