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GlossarySynaptic Plasticity

ability of synapses to change strength based on activity

Synaptic plasticity refers to the ability of synapses, the connections between neurons in the brain, to strengthen or weaken over time in response to increases or decreases in their activity. This process is fundamental for learning, memory, and overall brain adaptability, as it allows the neural network to reorganize and optimize its function based on experiences and new information.

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Anxiety and Depression-Like Behaviour Following Short-Term Finasteride Administration Is Associated With Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

research Anxiety-, and Depression-like Behaviour Following Short-Term Finasteride Administration is Associated with Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

April 2024 in “Journal of psychiatric research”

Short-term finasteride use in male rats caused anxiety, depression, and memory problems.

Repeated Finasteride Administration Promotes Synaptic Plasticity and Produces Antidepressant and Anxiolytic-Like Effects in Female Rats

research Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats

March 2024 in “Journal of Neuroscience Research”

Finasteride may reduce depression and anxiety in female rats and improve brain connectivity.

research Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids

22 citations , October 2019 in “Cerebral cortex”

Sex neurosteroids cause different effects on hippocampal synaptic plasticity in males and females.

research Different synaptic stimulation patterns influence the local androgenic and estrogenic neurosteroid availability triggering hippocampal synaptic plasticity in the male rat

10 citations , February 2017 in “European journal of neuroscience/EJN. European journal of neuroscience”

The availability of certain hormones and specific stimulation patterns affect long-term synaptic changes in the male rat brain.

The Interaction Between Finasteride and Corticosterone Levels: Implications for Depression and Anxiety-Like Behavior and Hippocampal Synaptic Plasticity in Male Rats

research The interaction between finasteride and corticosterone levels: implications for depression-, and anxiety-like behavior and hippocampal synaptic plasticity in male rats

May 2025 in “Psychopharmacology”

Chronic finasteride use in male rats doesn't strongly cause depression or anxiety due to adaptive stress hormone changes.

research Decision letter for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

January 2024

research Review for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

October 2023

research Author response for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

October 2023

research Decision letter for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

September 2023

research Review for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

September 2023

research Review for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

July 2023

Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals

research Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals

25 citations , November 2013 in “PLoS ONE”

Estrogen and androgen signals control synaptic changes in rat brains.

Local Synthesis and Function of Neuro-Estrogen and Neuro-Androgen: Impact on Hippocampus-Related Cognition and Neuronal Plasticity

research Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity

January 2026 in “Frontiers in Cellular Neuroscience”

Neurosteroids like neuro-estrogen and neuro-androgen are crucial for brain function and can improve cognition and protect against aging-related decline.

research Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids

61 citations , April 2018 in “Frontiers in endocrinology”

Sex steroids produced in the hippocampus are crucial for brain functions like memory and learning in rodents.

Bisphenol-A Antagonizes the Rapidly Modulating Effect of Dihydrotestosterone on Spinogenesis and Long-Term Potentiation of Hippocampal Neurons

research Bisphenol-A antagonizes the rapidly modulating effect of DHT on spinogenesis and long-term potentiation of hippocampal neurons

10 citations , December 2017 in “Chemosphere”

Bisphenol-A (BPA) increases connections between brain cells and boosts their activity, but it blocks the effects of a male hormone on brain cell plasticity.

research Pubertal hormones increase hippocampal expression of α4βδ GABAA receptors

5 citations , February 2019 in “Neuroscience letters”

Hormones during puberty increase certain receptors in the brain, and this change is influenced by estrogen levels.

research Sex‐dependent responsiveness of hippocampal neurons to sex neurosteroids: A role of Arc/Arg3.1

3 citations , January 2022 in “Journal of neuroendocrinology”

Sex hormones affect brain cells differently in males and females.

The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery, and Postpartum Are Reversed by Offspring Deprivation

research The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery and Postpartum are Reversed by Offspring Deprivation

August 2020 in “Current psychopharmacology”

Pregnancy and nursing increase certain brain activities in rats, but these changes disappear when the babies are taken away.

research Neo-synthesis of estrogenic or androgenic neurosteroids determine whether long-term potentiation or depression is induced in hippocampus of male rat

32 citations , October 2015 in “Frontiers in Cellular Neuroscience”

DHT is needed for long-term depression, while E2 is needed for full long-term potentiation in male rat brains.

Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

research Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

97 citations , December 2010 in “Journal of Neuroscience”

Midazolam impairs learning and memory by increasing neurosteroids through specific receptor activation.

research Formononetin: A Pathway to Protect Neurons

35 citations , July 2022 in “Frontiers in Integrative Neuroscience”

Formononetin may help protect the brain and treat neurological diseases.

research Adaptive Balance in Posterior Cerebellum

21 citations , March 2021 in “Frontiers in Neurology”

The posterior cerebellum helps maintain balance by adapting to sensory inputs and self-motion.

research Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis

11 citations , July 2015 in “Frontiers in Cellular Neuroscience”

Corticosterone makes ethanol more effective at blocking brain processes important for learning and memory.

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Related Terms

Research

research Anxiety-, and Depression-like Behaviour Following Short-Term Finasteride Administration is Associated with Impaired Synaptic Plasticity and Cognitive Behaviour in Male Rats

research Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats

research Sex-specific Difference of Hippocampal Synaptic Plasticity in Response to Sex Neurosteroids

research Different synaptic stimulation patterns influence the local androgenic and estrogenic neurosteroid availability triggering hippocampal synaptic plasticity in the male rat

research The interaction between finasteride and corticosterone levels: implications for depression-, and anxiety-like behavior and hippocampal synaptic plasticity in male rats

research Decision letter for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

research Review for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

research Author response for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

research Decision letter for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

research Review for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

research Review for "Repeated finasteride administration promotes synaptic plasticity and produces antidepressant‐ and anxiolytic‐like effects in female rats"

research Synaptic Long-Term Potentiation and Depression in the Rat Medial Vestibular Nuclei Depend on Neural Activation of Estrogenic and Androgenic Signals

research Local synthesis and function of neuro-estrogen and neuro-androgen: impact on the hippocampus-related cognition and neuronal plasticity

research Neurosteroids in Adult Hippocampus of Male and Female Rodents: Biosynthesis and Actions of Sex Steroids

research Bisphenol-A antagonizes the rapidly modulating effect of DHT on spinogenesis and long-term potentiation of hippocampal neurons

research Pubertal hormones increase hippocampal expression of α4βδ GABAA receptors

research Sex‐dependent responsiveness of hippocampal neurons to sex neurosteroids: A role of Arc/Arg3.1

research The Plastic and Functional Changes in Hippocampal Neurons During Pregnancy, Delivery and Postpartum are Reversed by Offspring Deprivation

research Neo-synthesis of estrogenic or androgenic neurosteroids determine whether long-term potentiation or depression is induced in hippocampus of male rat

research Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

research Formononetin: A Pathway to Protect Neurons

research Adaptive Balance in Posterior Cerebellum

research Corticosterone enhances the potency of ethanol against hippocampal long-term potentiation via local neurosteroid synthesis

research Locally Synthetized 17-β-Estradiol Reverses Amyloid-β-42-Induced Hippocampal Long-Term Potentiation Deficits

research Effect of Neurosteroid Withdrawal on Hippocampal GABA‐A Receptor α4‐Subunit Expression in Female Mice

research Synaptic processes and immune-related pathways implicated in Tourette syndrome

research Plasticity of GABAergic Inhibition

research Finasteride Treatment Inhibits Adult Hippocampal Neurogenesis in Male Mice

research Pericyte Plasticity in the Brain

research Ethanol-induced GABAA receptor alpha4 subunit plasticity involves phosphorylation and neuroactive steroids