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Did you mean T helper 17 cells?

GlossaryT helper 17 cells

specialized immune cells involved in inflammation and autoimmune responses

T helper 17 cells, often abbreviated as Th17 cells, are a subset of T cells, which are a type of white blood cell crucial for the immune system. Th17 cells play a key role in defending the body against bacterial and fungal infections by producing a specific set of signaling molecules called cytokines, particularly interleukin-17 (IL-17). They are also involved in inflammatory responses and have been implicated in various autoimmune diseases, where the immune system mistakenly attacks the body's own tissues.

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T Helper 17 Cell/Regulatory T-Cell Imbalance in Hidradenitis Suppurativa/Acne Inversa: The Link to Hair Follicle Dissection, Obesity, Smoking, and Autoimmune Comorbidities

research T helper 17 cell/regulatory T-cell imbalance in hidradenitis suppurativa/acne inversa: the link to hair follicle dissection, obesity, smoking and autoimmune comorbidities

66 citations , March 2018 in “British journal of dermatology/British journal of dermatology, Supplement”

An imbalance between certain immune cells is linked to a chronic skin condition and may be influenced by obesity, smoking, and autoimmune issues.

research 42905 Role of regulatory T and T-helper 17 cells in patients with acute diffuse and total alopecia

September 2023 in “Journal of the American Academy of Dermatology”

Increased Treg cells and IL-10 may help quick recovery in acute diffuse and total alopecia.

MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata

research MicroRNA-1246 Inhibits NFATc1 Phosphorylation and Regulates T Helper 17 Cell Activation in the Pathogenesis of Severe Alopecia Areata

January 2023 in “Annals of dermatology/Annals of Dermatology”

A substance called miR-1246 may help treat severe hair loss by reducing certain immune cell activities.

research The Role of T‐Helper 17 Cells and Regulatory T Cells in Acute Diffuse and Total Alopecia: The Increased Function of Regulatory T Cells May Explain the Favorable Prognosis

1 citations , May 2025 in “The Journal of Dermatology”

Increased regulatory T cell activity may lead to better outcomes in acute diffuse and total alopecia.

research Detection of subtypes of T helper cells and their cytokines in peripheral blood of patients with systematic lupus erythematosus and their clinical significances

January 2014 in “Journal of Jilin University”

Higher levels of certain immune cells and proteins are linked to more severe lupus symptoms.

research The potential of regulatory T cell-based therapies for alopecia areata

May 2023 in “Frontiers in Immunology”

Treg cell-based therapies might help treat hair loss from alopecia areata, but more research is needed to confirm safety and effectiveness.

research CD4 T cells from mice with alopecia areata express an effector like phenotype and can transfer disease

1 citations , May 2023 in “The Journal of Immunology”

CD4 T cells can cause alopecia areata by activating CD8 T cells to attack hair follicles.

research Class IIa HDAC4 and HDAC7 cooperatively regulate gene transcription in Th17 cell differentiation

16 citations , April 2024 in “Proceedings of the National Academy of Sciences”

HDAC4 and HDAC7 are crucial for Th17 cell development and could be targeted to treat inflammatory diseases.

research Targeting lymphoid-derived IL-17 signaling to delay skin aging

59 citations , June 2023 in “Nature Aging”

Blocking IL-17 signaling may reduce skin inflammation and delay aging.

research Local IL-17 orchestrates skin aging

1 citations , January 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

Blocking IL-17 signaling can delay skin aging and improve skin and hair health.

research An ROS‐Scavenging Treg‐Recruiting Hydrogel Patch for Diabetic Wound Healing

February 2024 in “Advanced Functional Materials”

The hydrogel patch helps heal diabetic wounds by releasing a healing agent in response to harmful molecules and improving skin regeneration.

Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis

research Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid LupusErythematosus by Weighted Gene Co-Expression Network Analysis

December 2022 in “Research Square (Research Square)”

Key genes linked to immune response are upregulated in hair follicles and skin tissues in chronic discoid lupus erythematosus.

research Identification of Biomarkers in Affected Hair Follicles from Chronic Discoid Lupus Erythematosus by Weighted Gene Co-Expression Network Analysis

October 2022 in “Research Square (Research Square)”

Key genes linked to immune response are highly active in lupus-affected hair follicles.

research Essential Role of STAT3 Signaling in Hair Follicle Homeostasis

6 citations , November 2021 in “Frontiers in immunology”

STAT3 signaling is important for healthy skin and hair follicles, and its disruption can lead to skin conditions like atopic dermatitis.

research Hepatitis C‐related mixed type vitiligo in a patient with Ivemark syndrome

1 citations , January 2014 in “The Journal of Dermatology”

A patient with Ivemark syndrome developed mixed type vitiligo after a hepatitis C infection, showing different treatment responses and immune cell involvement in the skin.

research Improved humoral immunity and protection against influenza virus infection with a 3D porous biomaterial vaccine

December 2022 in “bioRxiv (Cold Spring Harbor Laboratory)”

The new vaccine platform led to a stronger immune response and better protection against the flu than the traditional vaccine.

Molecular Correlation With Clinical Outcomes in an Open Label Clinical Trial of Oral Tofacitinib in Patients With Alopecia Areata

research 455 Molecular correlation with clinical outcomes in an open label clinical trial of oral tofacitinib in patients with alopecia areata

1 citations , April 2018 in “Journal of Investigative Dermatology”

Tofacitinib helped most patients with alopecia areata regrow hair and changes in immune cells were linked to the treatment's effectiveness.

research Regulatory T cells modulate bone marrow stromal cell osteogenesis by activating ROCK-myosin axis and cell contractility

January 2026

Regulatory T cells enhance bone formation by influencing cell mechanics.

IL-17-Producing Gamma Delta T Cells Enhance Bone Regeneration

research IL-17-producing γδ T cells enhance bone regeneration

343 citations , March 2016 in “Nature Communications”

IL-17-producing γδ T cells help improve bone healing.

The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target

research The Phenotype of Circulating Follicular-Helper T Cells in Patients with Rheumatoid Arthritis Defines CD200 as a Potential Therapeutic Target

32 citations , January 2012 in “Clinical & Developmental Immunology”

Targeting CD200 could be a new treatment for rheumatoid arthritis.

research The imbalance between Type 17 T-cells and regulatory immune cell subsets in psoriasis vulgaris

49 citations , August 2022 in “Frontiers in Immunology”

Psoriasis involves an imbalance between certain immune cells, and targeting these could help restore skin health.

research P130 The densities of T cells, Langerhans cells, and natural killer cells in uninvolved skin of patients with acne vulgaris

September 1997 in “Journal of the European Academy of Dermatology and Venereology”

People with acne have more CD4+ immune cells in their skin than healthy people.

Perforin Expression by Cutaneous Gamma Delta T Cells

research Perforins Expression by Cutaneous Gamma Delta T Cells

13 citations , August 2020 in “Frontiers in Immunology”

Gamma delta T cells in the skin help with healing and defense but can also cause autoimmune issues, and more research is needed to understand how they are activated.

research Sphingolipid metabolism orchestrates the establishment of the adult hair follicle stem cell niche to control skin homeostasis

January 2024 in “bioRxiv (Cold Spring Harbor Laboratory)”

A specific enzyme is essential for proper hair follicle stem cell development and healthy skin.

research Altered expression of intracellular Toll-like receptors in peripheral blood mononuclear cells from patients with alopecia areata

12 citations , March 2016 in “BBA clinical”

Increased Toll-like receptors in blood cells may contribute to alopecia areata and could be a target for new treatments.

Evaluation of Platelet-Rich Plasma on Hair Regrowth and Lesional T-Cell Cytokine Expression in Alopecia Areata: A Randomized Observer-Blinded, Placebo-Controlled, Split-Head Pilot Study

research Evaluation of platelet-rich plasma on hair regrowth and lesional T-cell cytokine expression in alopecia areata: A randomized observer-blinded, placebo-controlled, split-head pilot study

9 citations , December 2020 in “Journal of The American Academy of Dermatology”

Platelet-rich plasma may help restore immune balance in bald patches, but its effectiveness in treating hair loss is limited.

Alopecia Areata Is Characterized by Dysregulation in Systemic Type 17 and Type 2 Cytokines, Which May Contribute to Disease-Associated Psychological Morbidity

research Alopecia areata is characterized by dysregulation in systemic type 17 and type 2 cytokines, which may contribute to disease‐associated psychological morbidity

57 citations , April 2019 in “British journal of dermatology/British journal of dermatology, Supplement”

Alopecia areata involves immune system imbalances that may lead to depression and anxiety.

Plain Language Summaries of Various Dermatological Studies

research Plain language summaries

September 2016 in “British Journal of Dermatology”

Doctors need more training in skin cancer screening, a new treatment is effective for a skin condition, better diagnosis methods for skin cancer are available, hair loss in women may be linked to hormones and cholesterol, certain skin care products might cause hair loss, babies' skin gets weaker after birth, and a gene mutation might be linked to eczema.

research Editors' Picks

January 2012 in “Journal of Investigative Dermatology”

Small molecule DMF improves psoriasis and multiple sclerosis, adult skin cells can be made to grow new hair, certain skin cells initiate hair growth, IL-17C controls gut health and can cause skin inflammation, and skin cells produce IL-17 that can lead to psoriasis.

Androgenetic Alopecia And Hair Growth Promotion: Present And Future

research Androgenetic alopecia and hair growth promotion state of the art: Present and future

8 citations , October 1988 in “Clinics in Dermatology”

Current research explores hair growth drugs, while future research aims for personalized treatments.