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research The structure of human trichohyalin : potential multiple roles as a functional ef-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

2 citations , January 1993

Trichohyalin is a versatile protein involved in hair and skin structure.

research Dynamic expression of the zinc-finger transcription factor Trps1 during hair follicle morphogenesis and cycling

46 citations , November 2007 in “Gene Expression Patterns”

Trps1 plays a key role in hair follicle development and cycling.

research NFAT5 mediates hypertonic stress-induced atherosclerosis via activating NLRP3 inflammasome in endothelium

50 citations , August 2019 in “Cell Communication and Signaling”

NFAT5 triggers atherosclerosis under stress by activating inflammation in blood vessels.

research Regulatory mutations in TBX3 disrupt asymmetric hair pigmentation that underlies Dun camouflage color in horses

73 citations , December 2015 in “Nature Genetics”

Mutations in TBX3 cause horses to have more even hair color instead of Dun camouflage.

research Author response: Loss of Dnmt3a and Dnmt3b does not affect epidermal homeostasis but promotes squamous transformation through PPAR-γ

March 2017

Loss of Dnmt3a and Dnmt3b leads to more aggressive skin tumors, but blocking PPAR-γ can reduce this effect.

research Differential expression of KRT83 regulated by the transcript factor CAP1 in Chinese Tan sheep

5 citations , March 2017 in “Gene”

CAP1 decreases the expression of a hair-related protein in young Tan sheep's skin.

research Hair-thread tourniquet syndrome in a preterm baby

5 citations , November 2015 in “Turk Pediatri Arsivi-turkish Archives of Pediatrics”

A preterm baby's toes were saved from damage by quickly removing a thread that was cutting off circulation.

research A TP63 Mutation Causes Prominent Alopecia with Mild Ectodermal Dysplasia

2 citations , May 2020 in “The journal of investigative dermatology/Journal of investigative dermatology”

A TP63 gene mutation causes significant hair loss and mild skin, nail, and tooth abnormalities.

research Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene.

24 citations , July 1994 in “Molecular Endocrinology”

Researchers found an RNA transcript that might help control a growth factor linked to tumor development.

Oral Administration of Low-Dose Bisphenol A Promotes Proliferation of Ventral Prostate and Upregulates Prostaglandin D2 Synthase Expression in Adult Rats

research Oral administration of low-dose bisphenol A promotes proliferation of ventral prostate and upregulates prostaglandin D₂ synthase expression in adult rats

14 citations , June 2015 in “Toxicology and Industrial Health”

Low doses of BPA can increase prostate growth and change hormone levels in adult rats.

research Targeted expression of spermidine/spermine N1-acetyltransferase increases susceptibility to chemically induced skin carcinogenesis

54 citations , February 2002 in “Carcinogenesis”

Increasing SSAT makes skin more prone to cancer.

research The structure of human trichohyalin. Potential multiple roles as a functional EF-hand-like calcium-binding protein, a cornified cell envelope precursor, and an intermediate filament-associated (cross-linking) protein

161 citations , June 1993 in “Journal of Biological Chemistry”

Trichohyalin helps in hair and skin cell structure and function by binding calcium and linking proteins.

research 63418 JAK3/TEC kinase pathways are active in alopecia areata lesions, and their inhibition with Ritlecitinib prevents αCD3/αCD28+IL-2 induced immune privilege collapse in healthy hair follicles ex vivo

September 2025 in “Journal of the American Academy of Dermatology”

Ritlecitinib may help treat alopecia areata by protecting hair follicles.

research The pattern recognition receptor toll-like receptor 3 regulates skin barrier homeostasis

January 2014 in “eScholarship (California Digital Library)”

Toll-like receptor 3 helps repair the skin barrier after UV damage.

research 3,4,5-Tri-O-Caffeoylquinic Acid Promoted Hair Pigmentation Through β-Catenin and Its Target Genes

13 citations , March 2020 in “Frontiers in cell and developmental biology”

A substance called TCQA could potentially darken hair by activating certain genes and increasing melanin.

research RSPO1, a potent inducer of pancreatic β cell neogenesis

1 citations , May 2025 in “Cell Reports Medicine”

RSPO1 could help create new diabetes treatments by increasing pancreatic β cells.

research This Month in the Journal

July 2005 in “The American Journal of Human Genetics”

The AR gene is linked to male-pattern baldness, TNFSF4 to heart disease, SLC19A3 to BBGD, MCT8 to a syndrome, and segmental duplications to genetic variation.

research Control of pelage hair follicle development and cycling by complex interactions between follistatin and activin

81 citations , January 2003 in “The FASEB Journal”

Follistatin helps hair growth and cycling, while activin prevents it.

research Mealworm-Derived Protein Hydrolysates Enhance Adipogenic Differentiation via Mitotic Clonal Expansion in 3T3-L1 Cells

January 2025 in “Foods”

Mealworm protein helps fat cell development and may aid in metabolic health and hair growth.

research Expression of Long Noncoding RNA, HOTAIR, and MicroRNA-205 and Their Relation to Transforming Growth Factor β1 in Patients with Alopecia Areata

4 citations , January 2023 in “Skin Appendage Disorders”

Changes in certain RNA and protein levels may contribute to alopecia areata and could be treatment targets.

Impact of One-Week Administration of Dihydrotestosterone in Rat Anterior Pituitary Gland

research Treatment for chemotherapy‐induced alopecia in mice using parathyroid hormone agonists and antagonists linked to a collagen binding domain

24 citations , December 2011 in “International Journal of Cancer”

PTH-CBD agonists may help regrow hair after chemotherapy.

research Bone Morphogenetic Protein Signaling Inhibits Hair Follicle Anagen Induction by Restricting Epithelial Stem/Progenitor Cell Activation and Expansion

176 citations , September 2006 in “Stem Cells”

BMP signaling prevents hair growth by stopping stem cell activation.

research Identification of a secreted BMP antagonist, ectodin, integrating BMP, FGF, and SHH signals from the tooth enamel knot

243 citations , October 2003 in “Developmental biology”

Ectodin integrates BMP, SHH, and FGF signals in developing ectodermal organs.

research HMGB1 promotes hair growth via the modulation of prostaglandin metabolism

12 citations , April 2019 in “Scientific Reports”

A protein called HMGB1 helps hair grow by affecting prostaglandin metabolism.

research Impaired Hair Follicle Morphogenesis and Cycling with Abnormal Epidermal Differentiation in nackt Mice, a Cathepsin L-Deficient Mutation

57 citations , August 2002 in “American Journal Of Pathology”

Cathepsin L deficiency causes hair and skin issues in mice.

research A cluster of 21 keratin-associated protein genes within introns of another gene on human chromosome 21q22.3

34 citations , January 2004 in “Genomics”

A cluster of 21 keratin-associated protein genes important for hair growth was found on human chromosome 21.

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