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Keratin-associated proteins have ancient origins and were used for different purposes before being adapted for hair in mammals.

SOCS1 and SOCS3 help control skin inflammation and are important for developing treatments for skin diseases.

Senescent fibroblasts can help start tumors in normal skin cells.

Ca_v1.2 affects hair growth and could be a target for hair loss treatments.

Overexpressing CtBP1 in skin cells causes skin and hair problems.

Targeting ATM could help manage heart cell enlargement due to pressure overload.

A method was found to select hair follicle stem cells, and beta-catenin helps them grow and change.

A protein called IL-36γ causes skin side effects from certain cancer treatments when combined with a common skin bacteria.

Activating β-catenin increases melanocytes and decreases Schwann cells.

Loss of the p53 gene alone causes tumors, and losing both p53 and Rb genes speeds up aggressive skin cancer.

Dermal EZH2 controls skin cell growth and differentiation in mice.

AP-1 and TGFß work together to drive resistance in basal cell carcinoma, suggesting new treatment options.

IL-1β inhibits human hair follicle growth.

The C-terminal tail of AHF/trichohyalin is essential for organizing keratin filaments in keratinocytes.

SCF and ET-1 together significantly increase skin pigmentation and melanin production.

The hair keratin gene KRT81 is found in both normal and breast cancer cells and helps them invade surrounding tissues.

The tumor suppressor gene FLCN affects mitochondrial function and energy use in cells.

Wnt signaling is important for development and cell regulation but can cause diseases like cancer when not working properly.

HOXC13 is crucial for regulating hair keratin genes in hair follicles.

Some hair protein genes evolved early and were adapted for use in hair follicles.

Lack of functional CYLD in mice leads to early aging and cancer.

Enhancing CD8+ T cell function to induce ferroptosis in tumor cells may help treat skin melanoma.

Wnt/β-catenin signaling is crucial for cell fusion in placental development.

A new mutation in the STING protein causes a range of symptoms and its severity may be affected by other genetic variations; treatment with a specific inhibitor showed improvement in one patient.

Intermediate filaments are crucial for cell differentiation and stem cell function.

JAK inhibitors show promise for treating various skin diseases.

EGFR helps mouse hair follicles stop growing by reducing certain growth regulators.

KRT2.13 gene is similar to KRT2.9 but not expressed in hair follicles.

A new TP63 mutation was found in a baby with EEC syndrome, showing the need for TREC testing to check for immune issues.