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The C-terminal tail of AHF/trichohyalin is essential for organizing keratin filaments in keratinocytes.

PRSS35 enzyme may help start skin tumors and could be a target for cancer treatment.

Trametinib can effectively treat severe kaposiform lymphangiomatosis when other treatments fail.

There are two ways to start hair growth: one needs Stat3 and the other does not, but both need PI3K activation.

Krt15+ cells in mice can resist radiation, regenerate tissue, and start tumors, suggesting new cancer treatment targets.

Applying a specific inhibitor lightens skin and hair color.

Promising cancer treatments were found, but the manufacturer closed.

MPA increases cancer spread by boosting Eph A2 activity.

A KLK5 inhibitor effectively improved skin symptoms in a mouse model of Netherton Syndrome.

Deleting the MAD2L1 gene in mice led to rapid tumor growth despite chromosomal instability.

Inhibiting certain proteins harms hair follicle immunity and increases IL-33, affecting hair health.

LTBP1 is a key regulator in diseases and a potential target for new treatments.

Keratins K6 and K16 are expressed more freely in regenerating mouse skin than K1 and K10.

β-catenin helps hair follicle stem cells grow by activating a specific cell pathway.

Disrupting the Tsc2 gene in certain cells leads to thicker skin, larger hair, and changes in hair growth signaling, which can be partly reversed with specific treatment.

Activated β-catenin affects hair growth and skin thickness, and changes are reversible.

Cancer treatment drugs can cause permanent hair loss by damaging hair follicle stem cells, but a specific inhibitor might reverse this effect.

Baicalin may help treat severe drug-induced skin reactions.

Different keratins have unique expression patterns in mouse skin cells.

Cells from a skin condition can create new hair follicles and similar growths in mice, and a specific treatment can reduce these effects.

Blocking EGFR can cause skin inflammation by disrupting IL-1 signaling.

A substance called DKK-1 increases in balding areas and causes hair cells to die when exposed to DHT.

Tanshinone IIA helps protect tissue from low oxygen damage by activating certain cell pathways.

Topical rapamycin may effectively treat fibrous papules on the face.

IL-1β inhibits human hair follicle growth.

Keratins are crucial for tissue strength, and mutations in keratin genes can lead to various diseases, highlighting the need for targeted therapies.

New RIPK4 gene mutations were found to cause a type of skin and limb birth defect.

Wnt/β-catenin signaling is important for keeping skin cell attachment structures stable.

A PTH-based treatment improved hair regrowth better than ruxolitinib in a mouse model of hair loss.