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Did you mean TGF-beta signaling?

GlossaryTGF-beta signaling

cellular communication process regulating growth, differentiation, and immune responses

TGF-beta signaling, or Transforming Growth Factor-beta signaling, is a cellular communication process that regulates various biological functions, including cell growth, differentiation, and immune responses. This pathway involves the binding of TGF-beta proteins to specific receptors on the cell surface, which then activate intracellular molecules called SMADs to transmit signals to the nucleus, influencing gene expression. This pathway is crucial in maintaining tissue homeostasis and has implications in conditions like cancer, fibrosis, and alopecia.

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research Injectable platelet-rich fibrin promotes proliferation and trichogenic inductivityof dermal papilla cells through activating TGF-β/Smad signaling pathway

4 citations , April 2024 in “Cellular and Molecular Biology”

Injectable platelet-rich fibrin is better than platelet-rich plasma for promoting hair growth.

research From hair to liver: emerging application of hair follicle mesenchymal stem cell transplantation reverses liver cirrhosis by blocking the TGF-β/Smad signaling pathway to inhibit pathological HSC activation

4 citations , February 2022 in “PeerJ”

Hair follicle stem cell transplants can reverse liver cirrhosis by blocking harmful cell activation.

research Hair Follicle Development of Rex Rabbits Is Regulated Seasonally by Wnt10b/β-Catenin, TGFβ-BMP, IGF1, and EGF Signaling Pathways

1 citations , December 2023 in “Animals”

Winter provides the best fur quality for Rex rabbits due to seasonal changes in specific signaling pathways.

research Co-opting Developmental Signaling Pathways to Promote Wound Healing

1 citations , January 2018 in “Recent clinical techniques, results, and research in wounds”

Using developmental signaling pathways could improve adult wound healing by mimicking scarless embryonic healing.

research TGFβ signaling regulates lipogenesis in human sebaceous glands cells

44 citations , January 2013 in “BMC Dermatology”

TGFβ signaling prevents sebaceous gland cells from producing fats.

research CXXC5: A novel regulator and coordinator of TGF-β, BMP and Wnt signaling

28 citations , November 2018 in “Journal of Cellular and Molecular Medicine”

CXXC5 is a protein that controls cell growth and healing processes, and changes in its activity can lead to diseases like cancer and hair loss.

research 684 TGF-β signaling during the early phase of regeneration is required for wound-induced hair follicle neogenesis

July 2024 in “Journal of Investigative Dermatology”

TGF-β signaling is essential for new hair growth after a wound.

research Identification of key genes and signaling pathways related to Hetian sheep wool density by RNA-seq technology

7 citations , May 2022 in “PLOS ONE”

Certain genes and pathways are linked to the production of finer and denser wool in Hetian sheep.

research TGF-β Family Signaling in Epithelial Differentiation and Epithelial–Mesenchymal Transition

82 citations , February 2017 in “Cold Spring Harbor Perspectives in Biology”

The TGF-β family helps control how cells change and move, affecting skin, hair, and organ development.

research Hair-Growth-Promoting Effects of the Fish Collagen Peptide in Human Dermal Papilla Cells and C57BL/6 Mice Modulating Wnt/β-Catenin and BMP Signaling Pathways

October 2022 in “International Journal of Molecular Sciences”

Fish collagen peptides can significantly promote hair growth.

Ginsenoside CK Inhibits Androgenetic Alopecia by Regulating Wnt/Beta-Catenin and P53 Signaling Pathways in AGA Mice

research Ginsenoside CK inhibits androgenetic alopecia by regulating Wnt/β‐catenin and p53 signaling pathways in AGA mice

June 2023 in “Food frontiers”

Ginsenoside CK, found in Panax ginseng, can prevent hair loss by controlling certain growth pathways and promoting hair follicle development.

research Cooperation of TGF‐β and FGF signalling pathways in skin development

23 citations , May 2023 in “Cell Proliferation”

TGF-β and FGF pathways are crucial for skin development and regeneration.

research Edar Signaling in the Control of Hair Follicle Development

71 citations , November 2005 in “The journal of investigative dermatology. Symposium proceedings/The Journal of investigative dermatology symposium proceedings”

Edar signaling is crucial for proper hair follicle development and function.

research MiR-23b and miR-133 cotarget TGFβ2/NOTCH1 in dermal fibroblasts and affect hair follicle development in sheep

August 2023 in “Research Square (Research Square)”

Two microRNAs affect hair follicle development in sheep by targeting specific genes.

research Let-7b promotes alpaca hair growth via transcriptional repression of TGFβR I

13 citations , November 2015 in “Gene”

Let-7b helps alpaca hair grow by reducing TGFβR I protein.

Transforming Growth Factor-β Signaling-Mediated Wound Healing Is Required for Hair Follicle Neogenesis

research 484 Transforming growth factor-β signaling-mediated wound healing is required hair follicle neogenesis

November 2024 in “Journal of Investigative Dermatology”

TGF-β signaling is essential for new hair growth after wounds.

research Hedgehog signaling reprograms hair follicle niche fibroblasts to a hyper-activated state

25 citations , June 2022 in “Developmental cell”

Overactivating Hedgehog signaling makes hair follicle cells in mice grow hair faster and create more follicles.

research TGFβ family mimetic peptide promotes proliferation of human hair follicle dermal papilla cells and hair growth in C57BL/6 mice

9 citations , August 2018 in “Biomedical dermatology”

A peptide called DPS-1 helps human scalp cells grow and stimulates hair growth in mice.

Large-Scale Skin scRNA-Seq Profiling Highlights Distinct Body Site-Specific Ligand-Receptor Interactions and Pathways in Keratinocytes

research LB1671 Large-scale skin scRNA-seq profiling highlights distinct body site-specific ligand-receptor interactions and pathways in keratinocytes

August 2023 in “Journal of Investigative Dermatology”

Different body areas have unique skin cell communication patterns, explaining why certain skin diseases occur in specific regions.

research Regulatory pathways implicated in male androgenetic alopecia pathogenesis

November 2017 in “British Journal of Dermatology”

Genes controlling hair growth and immune response are disrupted in male pattern baldness.

LncRNA PlncRNA-1 Regulates Proliferation and Differentiation of Hair Follicle Stem Cells Through TGF-β1-Mediated Wnt/β-Catenin Signal Pathway

research LncRNA PlncRNA‑1 regulates proliferation and differentiation of hair follicle stem cells through TGF‑β1‑mediated Wnt/β‑catenin signal pathway

25 citations , November 2017 in “Molecular Medicine Reports”

PlncRNA-1 helps hair follicle stem cells grow and develop by controlling a specific cell signaling pathway.

research Dermal Blimp1 Acts Downstream of Epidermal TGFβ and Wnt/β-Catenin to Regulate Hair Follicle Formation and Growth

85 citations , June 2017 in “Journal of Investigative Dermatology”

Blimp1 is crucial for hair follicle growth and skin health.

research The Harmonies Played by TGF-β in Stem Cell Biology

156 citations , December 2012 in “Cell Stem Cell”

TGF-β is crucial for controlling stem cell behavior and changes in its signaling can lead to diseases like cancer.

research Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia

77 citations , June 2007 in “PLoS ONE”

Birds can regenerate inner ear cells using specific gene pathways, unlike mammals.

Wound Healing in Development: Mechanisms and Regulation

research Wound healing in development

29 citations , September 2012 in “Birth Defects Research”

Wounds heal without scarring in early development but later result in scars, and studying Wnt signaling could help control scarring.

research Expression Profiling Reveals Genes Involved in the Regulation of Wool Follicle Bulb Regression and Regeneration in Sheep

19 citations , April 2015 in “International Journal of Molecular Sciences”

The research identified genes and pathways important for sheep wool growth and shedding.

research MSC-EVs and UCB-EVs promote skin wound healing and spatial transcriptome analysis

12 citations , February 2025 in “Scientific Reports”

MSC-EVs and UCB-EVs improve skin wound healing and reduce scarring.

Time-Course RNA-Seq Analysis Reveals Stage-Specific and Melatonin-Triggered Gene Expression Patterns During the Hair Follicle Growth Cycle in Capra Hircus

research Time-course RNA-seq analysis reveals stage-specific and melatonin-triggered gene expression patterns during the hair follicle growth cycle in Capra hircus

9 citations , February 2022 in “BMC Genomics”

Melatonin affects gene expression in goat hair follicles, potentially increasing cashmere production.

Novel circRNAs From Cashmere Goats: Discovery, Integrated Regulatory Network, and Their Putative Roles in the Regeneration and Growth of Secondary Hair Follicles

research Novel circRNAs from cashmere goats: Discovery, integrated regulatory network, and their putative roles in the regeneration and growth of secondary hair follicles

7 citations , June 2022 in “Czech Journal of Animal Science”

Certain circular RNAs help cashmere goats grow more hair.

Construction and Functional Analysis of CeRNA Regulatory Network Related to the Development of Secondary Hair Follicles in Inner Mongolia Cashmere Goats

research Construction and functional analysis of ceRNA regulatory network related to the development of secondary hair follicles in Inner Mongolia cashmere goats

2 citations , August 2022 in “Frontiers in Veterinary Science”

The research found key RNA networks that may control hair growth in cashmere goats.