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GlossaryTGFBR2

regulates cell growth and differentiation through TGF-beta signaling

TGFBR2, or Transforming Growth Factor Beta Receptor 2, is a protein that plays a crucial role in cell signaling. It is part of the TGF-beta signaling pathway, which regulates various cellular processes, including cell growth, differentiation, and apoptosis. Mutations or alterations in TGFBR2 can lead to various diseases, including cancer and fibrosis, due to its role in controlling cell behavior.

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research 1325 Age-dependent loss of the stemness and antimicrobial defense function of dermal fibroblasts is mediated by TGFbeta

April 2018 in “Journal of Investigative Dermatology”

Aging reduces skin cell renewal and defense against germs due to TGFbeta, but blocking TGFbeta could help restore these functions.

research Effects of TGFBR1 on Proliferation of Dermal Papilla Cells in Fine-Wool Sheep

December 2025 in “Animals”

TGFBR1 slows down cell growth in fine-wool sheep hair follicles.

research Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

159 citations , October 2015 in “Science Advances”

Blocking JAK-STAT signaling can lead to hair growth.

Epidermal β-Catenin Activation Remodels the Dermis via Paracrine Signaling to Distinct Fibroblast Lineages

research Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

115 citations , February 2016 in “Nature Communications”

Epidermal β-catenin activation changes the dermis by signaling different fibroblast types.

research Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues

111 citations , June 2002 in “The EMBO Journal”

Too much Smad7 can cause serious changes in skin tissues, including problems with hair growth, thymus shrinkage, and eye development issues.

Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

54 citations , November 2017 in “Scientific Reports”

The study found that certain microRNAs are higher in the cells and lower in the fluid of women with a specific type of polycystic ovary syndrome, and one microRNA could potentially help diagnose the condition.

research Role of stem/progenitor cells in reparative disorders

29 citations , December 2012 in “Fibrogenesis & Tissue Repair”

Adult stem cells are important for tissue repair and have therapeutic potential, but more research is needed to fully use them.

research Comparative study on seasonal hair follicle cycling by analysis of the transcriptomes from cashmere and milk goats

25 citations , February 2019 in “Genomics”

Cashmere and milk goats have different hair growth cycles and gene expressions, which could help improve wool production.

research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

20 citations , December 2020 in “Frontiers in Immunology”

The immune processes causing VKH and vitiligo are similar in dogs and humans.

research miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades

15 citations , November 2024 in “Journal of Advanced Research”

miR-3606-3p reduces skin fibrosis by blocking key signaling pathways.

research Seasonal Gene Expression Profile Responsible For Hair Follicle Development In Angora Goats

2 citations , March 2022 in “Research Square (Research Square)”

Seasonal changes affect gene activity linked to hair growth in Angora goats, influencing mohair quality.

research Whole blood transcriptome profiling identifies candidate genes associated with alopecia in male giant pandas (Ailuropoda melanoleuca)

1 citations , April 2022 in “BMC Genomics”

Researchers found genes linked to hair loss in male giant pandas.

research Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration

August 2024 in “Life Science Alliance”

Helminth protein helps wounds heal better by reducing scarring and promoting tissue growth.

research Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

January 2023 in “Kafkas üniversitesi veteriner fakültesi dergisi/Kafkas üniversitesi veteriner fakültesi dergisi”

Seasonal changes affect gene activity linked to hair growth in Angora goats.

research Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora goats

November 2022 in “Research Square (Research Square)”

Seasonal changes affect hair growth genes in Angora goats, possibly influencing mohair quality.

research 414 A new form of ectodermal dysplasia caused by mutations in TSPEAR

April 2016 in “Journal of Investigative Dermatology”

Mutations in the TSPEAR gene cause a new form of ectodermal dysplasia affecting hair and tooth development.

research The hair cycle

375 citations , February 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research The hair cycle

103 citations , January 2006 in “Journal of Cell Science”

The document concludes that the hair cycle is a complex process involving growth, regression, and rest phases, regulated by various molecular signals.

research Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia

77 citations , June 2007 in “PLoS ONE”

Birds can regenerate inner ear cells using specific gene pathways, unlike mammals.

Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor Beta 2 Expression

research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor β2 Expression

64 citations , March 2005 in “Journal of Investigative Dermatology”

Brain-Derived Neurotrophic Factor (BDNF) slows down hair growth and promotes hair follicle regression.

research The control of hair growth: An overview

62 citations , July 1993 in “Journal of Investigative Dermatology”

Hair growth is influenced by interactions between skin layers, growth factors, and hormones, but the exact mechanisms are not fully understood.

Follicular Dermal Papilla Structures by Organization of Epithelial and Mesenchymal Cells in Interfacial Polyelectrolyte Complex Fibers

research Follicular dermal papilla structures by organization of epithelial and mesenchymal cells in interfacial polyelectrolyte complex fibers

40 citations , June 2013 in “Biomaterials”

Scientists created 3D hair-like structures that could help study hair growth and test treatments.

research The regeneration blastema of lizards: an amniote model for the study of appendage replacement

39 citations , April 2015 in “Regeneration”

Lizards can regrow their tails, and studying this process helps understand scar-free healing and limb regeneration.

research Tuning Wnt Signals for More or Fewer Hairs

39 citations , January 2013 in “Journal of Investigative Dermatology”

Changing Wnt signaling can lead to more or less hair growth and might help treat hair loss and skin conditions.

research 878 Individual variation in balance between platelet-secreted growth factors causing contradictory effects on hair follicle could potentially impact response to PRP therapy in patients with scalp hair loss

1 citations , April 2018 in “Journal of Investigative Dermatology”

People respond differently to hair loss treatment with PRP because of individual differences in growth factors from platelets.

research Anti-Hair Loss Effect of Veratric Acid on Dermal Papilla Cells

March 2025 in “International Journal of Molecular Sciences”

Veratric Acid may help promote hair growth and reduce hair loss.

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Related Terms

Research

research 1325 Age-dependent loss of the stemness and antimicrobial defense function of dermal fibroblasts is mediated by TGFbeta

research Effects of TGFBR1 on Proliferation of Dermal Papilla Cells in Fine-Wool Sheep

research Pharmacologic inhibition of JAK-STAT signaling promotes hair growth

research Epidermal β-catenin activation remodels the dermis via paracrine signalling to distinct fibroblast lineages

research Overexpression of Smad7 results in severe pathological alterations in multiple epithelial tissues

research Differential Expression of miR-93 and miR-21 in Granulosa Cells and Follicular Fluid of Polycystic Ovary Syndrome Associating with Different Phenotypes

research Role of stem/progenitor cells in reparative disorders

research Comparative study on seasonal hair follicle cycling by analysis of the transcriptomes from cashmere and milk goats

research Case Series: Gene Expression Analysis in Canine Vogt-Koyanagi-Harada/Uveodermatologic Syndrome and Vitiligo Reveals Conserved Immunopathogenesis Pathways Between Dog and Human Autoimmune Pigmentary Disorders

research miR-3606-3p alleviates skin fibrosis by integratively suppressing the integrin/FAK, p-AKT/p-ERK, and TGF-β signaling cascades

research Seasonal Gene Expression Profile Responsible For Hair Follicle Development In Angora Goats

research Whole blood transcriptome profiling identifies candidate genes associated with alopecia in male giant pandas (Ailuropoda melanoleuca)

research Helminth protein enhances wound healing by inhibiting fibrosis and promoting tissue regeneration

research Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora Goats

research Seasonal Gene Expression Profile Responsible for Hair Follicle Development in Angora goats

research 414 A new form of ectodermal dysplasia caused by mutations in TSPEAR

research The hair cycle

research The hair cycle

research Large Scale Gene Expression Profiles of Regenerating Inner Ear Sensory Epithelia

research Control of Human Hair Growth by Neurotrophins: Brain-Derived Neurotrophic Factor Inhibits Hair Shaft Elongation, Induces Catagen, and Stimulates Follicular Transforming Growth Factor β2 Expression

research The control of hair growth: An overview

research Follicular dermal papilla structures by organization of epithelial and mesenchymal cells in interfacial polyelectrolyte complex fibers

research The regeneration blastema of lizards: an amniote model for the study of appendage replacement

research Tuning Wnt Signals for More or Fewer Hairs

research Methionine can subside hair follicle development prejudice of heat‐stressed rex rabbits

research Mimicking Hair Disorders by Genetic Manipulation of Organ-Cultured Human Hair Follicles

research Estrogen modulates mesenchymal-epidermal interactions in the adult nipple

research Strawberry water-extract increases cellular dehydrogenase activity in human follicle dermal papilla cells

research 878 Individual variation in balance between platelet-secreted growth factors causing contradictory effects on hair follicle could potentially impact response to PRP therapy in patients with scalp hair loss

research Anti-Hair Loss Effect of Veratric Acid on Dermal Papilla Cells