May 2025 in “Frontiers in Pharmacology” New treatments are needed for non-scarring alopecia due to current limitations.
Advancements in diagnostics, treatments, and technology have improved hair loss detection and restoration, with some types being reversible.
January 2025 in “Clinical Cosmetic and Investigational Dermatology” Pediatric alopecia areata is more immune-active than adult cases, suggesting age-specific treatments and potential use of JAK inhibitors.
June 2024 in “Frontiers in immunology” Sequential therapy with dupilumab and baricitinib improved hair regrowth and atopic dermatitis in a child without adverse reactions.
April 2024 in “Journal of translational medicine” MJ04, a new compound, effectively promotes hair growth and is a potential topical treatment for hair loss.
February 2024 in “World journal of stem cells” Adipose-derived stem cells can help repair and improve eye tissues and appearance.
May 2023 in “International Journal of Molecular Sciences” Mesenchymal stem cells could help treat radiation-induced bladder damage but more research is needed to overcome current limitations.
ILC1-like cells can independently cause alopecia areata by affecting hair follicles.
March 2022 in “Wound practice & research” New treatments for alopecia areata show promise, but standardized guidelines are needed.
July 2019 in “Dermatology practical & conceptual” The study found that alopecia areata is strongly linked to autoimmune diseases and may indicate a genetic predisposition to such conditions.
March 2017 in “Current dermatology reports” Topical JAK inhibitors can effectively treat alopecia areata and vitiligo by modulating immune responses.
146 citations
,
January 2004 in “Hormones” Human skin acts like a hormone-producing organ, making and managing various hormones important for skin and hair health.
40 citations
,
January 2022 in “Nutrients” Diet can influence inflammatory skin diseases.
36 citations
,
May 2025 in “Antioxidants” Lipid peroxidation worsens skin diseases but may help treat cancer.
2 citations
,
June 2023 in “PeerJ” Chronic inflammation can cause cancer by making stem cells divide and mutate.
May 2025 in “Orphanet Journal of Rare Diseases” TNF-α blockers and IL inhibitors improve symptoms in most patients with severe scalp condition, but more research is needed.
Thermal spring waters and their microbes could be good for skin health and treating some skin conditions in skincare products.
January 2026 in “Journal of Investigative Dermatology” Special cells can help regrow hair in alopecia areata.
278 citations
,
March 2013 in “Gut” Anti-IL-12/IL-23 antibody therapy effectively treats psoriasiform skin lesions in IBD patients.
12 citations
,
April 2017 in “Experimental and Therapeutic Medicine” Patients with severe active alopecia areata have lower CD200 expression and an imbalance in their immune system.
9 citations
,
May 2005 in “Expert Review of Clinical Immunology” Blocking interferon-gamma might help treat various autoimmune diseases.
7 citations
,
January 2019 in “Dermatology Online Journal” Ustekinumab treatment didn't prevent frontal fibrosing alopecia.
4 citations
,
January 2011 in “Journal of UOEH” Autoimmune hair loss may be linked to increased Th1 and Th17 cells and decreased Th2 cells.
2 citations
,
April 2018 in “Journal of Investigative Dermatology” Frontal fibrosing alopecia shows increased inflammation and JAK-STAT pathway activity without reduced hair proteins.
2 citations
,
May 2025 in “Journal of Clinical Medicine” Upadacitinib is safe and effective for treating alopecia areata and atopic dermatitis in children.
1 citations
,
July 2025 in “Frontiers in Genetics” FilaggrinHigh melanomas have active FGFR signaling and weak GNA14 and Th1 signatures.
1 citations
,
April 2023 in “World Journal of Urology” Finasteride reduces some inflammation in BPH but not all.
April 2019 in “Journal of Investigative Dermatology” Targeting immune pathways like JAK/STAT may help treat frontal fibrosing alopecia.
April 2018 in “Journal of Investigative Dermatology” Both Th1 and Th2 immune responses are increased in alopecia areata, with Th2 response more strongly linked to how severe the disease is.
April 2023 in “Journal of Investigative Dermatology” Chronic graft-versus-host disease in the skin shows strong Th1 immune response and unique barrier issues.