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Benzo[c]quinolizin-3-ones Theoretical Investigation: SAR Analysis and Application to Untested Compounds

research Benzo[c]quinolizin-3-ones Theoretical Investigation: SAR Analysis and Application to Nontested Compounds

6 citations , August 2004 in “Journal of Chemical Information and Computer Sciences”

The research found a link between certain molecular features and the biological activity of BC3, which can help identify or create new active compounds.

Differential Inhibition by Tedisamil and Glibenclamide of the Responses to Cromakalim and Minoxidil Sulphate in Rat Isolated Aorta

research Differential inhibition by tedisamil (KC 8857) and glibenclamide of the responses to cromakalim and minoxidil sulphate in rat isolated aorta

34 citations , February 1992 in “Naunyn-schmiedebergs Archives of Pharmacology”

Tedisamil and glibenclamide affect cromakalim and minoxidil sulphate differently in rat aorta.

research Effects of Fetal Exposure to Diazoxide in Man

42 citations , August 1972 in “Archives of Disease in Childhood”

Fetal exposure to diazoxide can cause hair loss and abnormal hair growth in infants.

Nonsteroidal Inhibitors of Human Type I Steroid 5α-Reductase

research Nonsteroidal inhibitors of human type I steroid 5-.alpha.-reductase

89 citations , February 1993 in “Journal of Medicinal Chemistry”

New compounds called benzoquinolinones may treat conditions linked to excess DHT.

Synthesis and In Vitro Study of 17β-[N-Ureylene-N,N′-Disubstituted]-4-Methyl-4-Aza-5α-Androstan-3-Ones as Selective Inhibitors of Type I 5α-Reductase

research Synthesis and in vitro study of 17β-[N-ureylene-N,N′-disubstituted]-4-methyl-4-aza-5α-androstan-3-ones as selective inhibitors of type I 5α-reductase

5 citations , February 1997 in “Bioorganic & Medicinal Chemistry”

New compounds were made that effectively block a specific enzyme related to androgen conditions.

research Synthesis and anticancer activity evaluation of Novel 6 mercaptopurine derivatives.

January 2015 in “Journals & Books Hosting (International Knowledge Sharing Platform)”

Compound 1 showed promising anticancer activity.

research GROWTH OF HEAD HAIR DURING TREATMENT WITH DIAZOXIDE

June 1975 in “Lancet”

A bald man grew hair on his head after taking a drug called diazoxide, but lost it again when he stopped the medication.

research Tuning Scaffold Properties of New 1,4-Substituted Pyrrolo[3,2-c]quinoline Derivatives Endowed with Anticancer Potential, New Biological and In Silico Insights

December 2025 in “Biomolecules”

Compound 7p shows strong potential as an anticancer agent.

research Design and synthesis of novel androgen receptor antagonists with sterically bulky icosahedral carboranes

45 citations , August 2005 in “Bioorganic & medicinal chemistry”

New compounds with carborane showed anti-androgen effects similar to flutamide.

Synthesis of Spiro[cyclohexane-1,2'-[2H]indene] Derivatives as Inhibitors of Steroid 5α-Reductase

research Synthesis of Spiro[cyclohexane-1,2?-[2H]indene] derivatives as inhibitors of steroid 5?-reductase

8 citations , June 1995 in “Helvetica Chimica Acta”

Compound 15a was effective in inhibiting 5α-reductase.

research Ligand Based 3D-QSAR Study on a Series of Steroidal Human 5α-Reductase Inhibitors

3 citations , August 2010 in “Letters in Drug Design & Discovery”

research Synthesis and Evaluation of 2‘-Substituted 4-(4‘-Carboxy- or 4‘-carboxymethylbenzylidene)-N-acylpiperidines: Highly Potent and in Vivo Active Steroid 5α-Reductase Type 2 Inhibitors

22 citations , June 2002 in “Journal of Medicinal Chemistry”

Compounds 15, 20, and 25 are strong inhibitors of human steroid 5α-reductase type 2.

research Synthesis of avicequinone c and analogs toward the study of 5α-reductase inhibitory activity

January 2015

2-Hydroxy-1,4-naphthoquinone is a strong 5α-reductase inhibitor.

research Steroid 5α-Reductase Inhibitors

42 citations , May 2003 in “Mini-reviews in Medicinal Chemistry”

New steroidal compounds could be effective for treating conditions related to 5α-reductase enzyme activity.

research Oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent.

22 citations , June 1991 in “Clinical Therapeutics”

Oxiconazole nitrate cream is effective and safe for treating various fungal skin infections.

Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

research Verification of the Major Metabolic Oxidation Path for the Naphthoyl Group in Chemoattractant Receptor-Homologous Molecule Expressed on Th2 Cells (CRTh2) Antagonist 2-(2-(1-Naphthoyl)-8-fluoro-3,4-dihydro-1H-pyrido[4,3-b]indol-5(2H)-yl)acetic Acid (Setipiprant/ACT-129968)

6 citations , September 2015 in “Journal of Medicinal Chemistry”

The document confirms the structures of major metabolites of the CRTh2 antagonist Setipiprant and identifies minor metabolites.

Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning Through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

research Midazolam Inhibits Hippocampal Long-Term Potentiation and Learning through Dual Central and Peripheral Benzodiazepine Receptor Activation and Neurosteroidogenesis

97 citations , December 2010 in “Journal of Neuroscience”

Midazolam impairs learning and memory by increasing neurosteroids through specific receptor activation.

research In vivo and in vitro effect of novel 4,16-pregnadiene-6,20-dione derivatives, as 5α-reductase inhibitors

27 citations , July 2008 in “The Journal of Steroid Biochemistry and Molecular Biology”

The new compounds may be more effective and cheaper than current treatments for conditions like baldness.

research 11β-Hydroxysteroid dehydrogenase type 1 inhibitors for the treatment of type 2 diabetes

43 citations , August 2010 in “Expert Opinion on Investigational Drugs”

Inhibitors of 11β-HSD1 show potential for treating type 2 diabetes but require more testing for safety and effectiveness.

research Oral zinc sulphate in treatment of patients with thallium poisoning: A clinical therapeutic trial

June 2011 in “Journal of clinical and experimental investigations”

Oral zinc sulphate is an effective and safe treatment for thallium poisoning.

research Generation of comparative pharmacophoric model for steroidal 5α-reductase I and II inhibitors: A 3D-QSAR study on 6-azasteroids

13 citations , January 2015 in “Steroids”

The study created a model to help design new inhibitors for steroidal 5α-reductase enzymes.

research Oxiconazole nitrate: pharmacology, efficacy, and safety of a new imidazole antifungal agent.

14 citations , January 1991 in “PubMed”

Oxiconazole nitrate cream is effective and well-tolerated for treating various fungal skin infections.

research A Novel Ion – selective Polymeric Membrane Sensor for Determining Thallium(I) With High Selectivity

45 citations , February 2011 in “IOP Conference Series Materials Science and Engineering”

The sensor accurately measures thallium ions in solutions with high selectivity.

research Flurandrenolide

January 2004

research Dark cytotoxicity beyond photo-induced one of silica nanoparticles incorporated with RuII nitrosyl complexes and luminescent {Mo6I8} cluster units

3 citations , September 2023 in “Journal of Photochemistry and Photobiology A Chemistry”

research Clinical and immunologic parameters during thalidomide treatment of lupus erythematosus

64 citations , May 2000 in “International Journal of Dermatology”

Thalidomide improved lupus symptoms but caused nerve damage in some patients.

research Protection from ifosfamide-induced alopecia by topical thiols in young rats

3 citations , January 1990 in “Cancer chemotherapy and pharmacology”

Topical thiols may prevent hair loss caused by certain chemotherapy drugs.

research Oral zinc sulphate in treatment of patients with thallium poisoning: A clinical therapeutic trial

2 citations , June 2011 in “Journal of clinical and experimental investigations”

Oral zinc sulphate is an effective and safe treatment for thallium poisoning, especially for skin and hair symptoms.

research Rational Design and Synthesis of 4-((1R,2R)-2-Hydroxycyclohexyl)-2(trifluoromethyl)benzonitrile (PF-998425), a Novel, Nonsteroidal Androgen Receptor Antagonist Devoid of Phototoxicity for Dermatological Indications

23 citations , October 2008 in “Journal of medicinal chemistry”

PF-998425 is a new, effective, and non-phototoxic treatment for skin conditions related to androgens.

research Natural Product-InspiredBis(trifluoromethyl) PhenylHydroxycinnamate Derivatives as Promising Nonsteroidal Inhibitorsof Human Steroid 5α-Reductase Type-1: Synthesis, InVitro, and In Silico Studies

August 2025 in “OPAL (Open@LaTrobe) (La Trobe University)”

Certain hydroxycinnamate derivatives may effectively inhibit enzymes linked to hair loss with low toxicity.

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