Tofacitinib significantly improved symptoms in a patient with overlapping autoimmune disorders.
24 citations
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March 2008 in “Neuroscience Research” Cat paws have complex touch sensors for detailed sensory processing.
86 citations
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August 2011 in “Toxicological sciences” TCDD speeds up skin barrier formation by increasing certain gene expressions.
37 citations
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January 1986 in “Carcinogenesis” ODC expression in mouse skin and tumors is varied and can be inhibited by retinoic acid or cycloheximide.
9 citations
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October 2025 in “MedComm” PROTACs offer new ways to treat hard-to-target diseases, with promising drugs for cancer in advanced trials.
35 citations
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September 2012 in “PloS one” Two distinct pathways direct proteins to vacuoles in Arabidopsis, affecting root hair growth and protein targeting.
17 citations
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October 2012 in “European Journal of Pharmacology” Toluene lowers body temperature through different mechanisms depending on the concentration.
1 citations
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April 2020 in “medRxiv (Cold Spring Harbor Laboratory)” The study found that Tourette Syndrome may be linked to certain immune system processes and synaptic signaling.
Tofacitinib significantly improved hair loss and lesions in a patient with overlapping autoimmune disorders.
April 2012 in “Neuropediatrics” Trichothiodystrophy is a rare genetic disorder causing hair issues and sometimes linked to DNA repair defects.
5 citations
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September 2020 in “Proceedings - Baylor University. Medical Center” Tofacitinib successfully treated a woman's severe symptoms from a rare autoimmune condition.
29 citations
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September 2024 in “AAPS PharmSciTech” Transcutol® helps drugs penetrate the skin more effectively in various formulations.
April 2026 in “Future Medicinal Chemistry” Proteolysis-Targeting Chimeras (PROTACs) have significantly transformed drug discovery by utilizing a unique catalytic degradation mechanism that targets and degrades specific proteins. This technology has progressed from a laboratory concept to achieving clinical breakthroughs, demonstrating its potential in treating various diseases. PROTACs offer advantages over traditional inhibitors by providing sustained protein degradation, which can lead to more effective and durable therapeutic outcomes. The development of PROTACs has opened new avenues for targeting previously "undruggable" proteins, marking a pivotal advancement in the field of medicinal chemistry and pharmacology.
1 citations
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January 2024 in “Pharmaceuticals” A new carrier improves skin delivery of tofacitinib for treating inflammatory skin diseases.
32 citations
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August 2016 in “Science Signaling” Alopecia areata patients show unique protein activity patterns, suggesting imbalanced signaling pathways.
33 citations
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May 2017 in “Journal of Clinical Oncology” ETC-159 was safe up to 30 mg, but no tumor shrinkage was seen.
January 1999 in “American Journal of Medical Genetics Part A” The report expanded knowledge of MBTPS1-related disorders by identifying new symptoms.
106 citations
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February 2014 in “eLife” Lanceolate complexes in mouse hair follicles are essential for touch and depend on specific cells for maintenance and regeneration.
Low levels of tenuazonic acid can severely damage vital organs.
May 2017 in “Journal of The American Academy of Dermatology” An intact skin barrier is crucial to prevent infection in cases of tether-induced tenosynovitis.
October 2025 in “Brazilian Journal of Veterinary Research and Animal Science” Neotropical porcupines can get co-infected with poxvirus and Toxoplasma gondii.
44 citations
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May 2023 in “MedComm” PROTAC technology shows promise for cancer treatment but needs more effective E3 ligase recruiters.
5 citations
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November 2020 in “Frontiers in Cell and Developmental Biology” The "Two-Cell Assemblage" assay is a new, simple method to identify substances that may promote hair growth.
2 citations
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June 2020 in “Clinical Journal of Gastroenterology” Tofacitinib effectively treated both ulcerative colitis and alopecia areata in two patients.
29 citations
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January 2021 in “Translational Psychiatry” The research suggests that Tourette syndrome is linked to both brain signaling and immune system pathways.
20 citations
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June 2019 in “JAAD Case Reports” Tofacitinib can cause skin eruptions similar to palmoplantar pustulosis.
A new imaging method helps see and study touch nerve endings in mouse skin.
5 citations
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January 2021 in “Inflammatory Bowel Diseases” Tofacitinib improved ulcerative colitis, skin ulcers, and hair loss in a patient who didn't respond well to other treatments.
1 citations
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April 2023 in “International journal of molecular sciences” Certain skin proteins can form anchoring structures without the protein AMACO.
11 citations
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January 2018 in “Acta dermato-venereologica” Tofacitinib works better and is more tolerable for severe alopecia than conventional treatments and DPCP immunotherapy.