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GlossaryTopical Finasteride

medication applied to the scalp to treat hair loss

Topical Finasteride is a medication applied directly to the scalp to treat hair loss, particularly androgenetic alopecia (male or female pattern baldness). Unlike oral finasteride, which can have systemic side effects, the topical form aims to reduce these risks by delivering the drug directly to the affected area, thereby minimizing its absorption into the bloodstream.

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Effects of a Novel Finasteride 0.25% Topical Solution on Scalp and Serum Dihydrotestosterone in Healthy Men with Androgenetic Alopecia

research Effects of a novel finasteride 0.25% topical solution on scalp and serum dihydrotestosterone in healthy men with androgenetic alopecia

42 citations , December 2015 in “International Journal of Clinical Pharmacology and Therapeutics”

The 0.25% finasteride solution, when applied once a day, effectively reduces scalp DHT, potentially minimizing sexual side-effects linked to a systemic DHT reduction.

research A Systematic Review of Topical Finasteride in the Treatment of Androgenetic Alopecia in Men and Women.

23 citations , April 2018 in “PubMed”

Topical finasteride reduces hair loss and promotes hair growth in men and women.

research Formulation and In-vivo Assessment of Topical Polyherbal Hair Serum to Promote Hair Growth

December 2023 in “International journal of drug delivery technology”

The polyherbal hair serum helped prevent hair loss and improved hair growth better than the usual treatment.

Efficacy and Safety of Topical Combination of 3% Minoxidil and 0.25% Finasteride Versus 3% Minoxidil Solution in Female-Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

research Efficacy and safety of topical combination of 3% minoxidil and 0.25% finasteride versus 3% minoxidil solution in female-pattern hair loss: A randomized, double-blind, controlled study

1 citations , August 2018 in “Journal of The American Academy of Dermatology”

Combination of minoxidil and finasteride is more effective in increasing hair diameter than minoxidil alone for female-pattern hair loss.

research Topical ketoconazole: a systematic review of current dermatological applications and future developments

39 citations , January 2019 in “Journal of Dermatological Treatment”

Ketoconazole cream is effective for skin conditions like seborrheic dermatitis and may help with hair loss and other skin issues, with generally mild side effects.

research The Scalp

July 2021 in “CRC Press eBooks”

Healthy scalp is crucial for hair growth and preventing hair loss.

research CLINICAL UPDATES IN HAIR

19 citations , January 1997 in “Dermatologic Clinics”

Most treatments for hair loss in 1997 were not effective for most people, and maintaining hair growth was difficult.

research Treatment of hyperandrogenism in polycystic ovary syndrome

1 citations , October 2010 in “Cambridge University Press eBooks”

Hormonal therapies are effective for managing hair and skin symptoms in women with PCOS.

research Dermatologic care of the transgender patient

41 citations , December 2016 in “International Journal of Women's Dermatology”

Hormone therapy and surgeries for transgender individuals affect their skin and hair, requiring specific dermatologic treatments and respectful care.

Pilosebaceous Unit: Structure, Function, and Disorders

research Pilosebaceous Unit (PSU)

January 2003 in “Elsevier eBooks”

Androgens and other hormones affect hair growth and skin conditions like acne.

Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

research Efficacy of Topical Combination of 0.25% Finasteride and 3% Minoxidil Versus 3% Minoxidil Solution in Female Pattern Hair Loss: A Randomized, Double-Blind, Controlled Study

36 citations , September 2018 in “American Journal of Clinical Dermatology”

Combination of 0.25% finasteride and 3% minoxidil works better than just 3% minoxidil for increasing hair thickness in women.

Comparative Efficacy of Minoxidil and 5-Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta-Analysis Study of Current Empirical Evidence

research Comparative Efficacy of Minoxidil and 5‐Alpha Reductase Inhibitors Monotherapy for Male Pattern Hair Loss: Network Meta‐Analysis Study of Current Empirical Evidence

June 2025 in “Journal of Cosmetic Dermatology”

Dutasteride 0.5 mg/day is the most effective treatment for male pattern hair loss.

research Do non-prescription products help in managing androgenic alopecia?

December 2024 in “Skin Appendage Disorders”

Non-prescription products can help manage androgenic alopecia.

research Emerging Therapies for Acne Vulgaris

22 citations , March 2018 in “American Journal of Clinical Dermatology”

New acne treatments show promise as alternatives to traditional therapies.

research Notes from the Editor Emeritus: Medical therapy for hair loss: what we know and what we need to find out

January 2013 in “Hair transplant forum international”

Minoxidil and finasteride are effective for male hair loss; minoxidil also helps female hair loss, with some treatments needing more research.

research Treatment of female pattern hair loss.

2 citations , October 2012 in “PubMed”

Topical minoxidil effectively treats Female Pattern Hair Loss in women of all ages and hormone levels, but evidence for antiandrogens is limited.

research The current treatments and perspectives for androgenetic alopecia

January 2009 in “Folia Pharmacologica Japonica”

Finasteride and minoxidil are the main effective treatments for hair loss from androgenetic alopecia.

research Finasteride-Loaded Phospholipid-Bile Salt Mixed Micelles for Targeted Follicular Delivery in Androgenetic Alopecia.

March 2026 in “PubMed”

A new topical treatment using micelles shows promise for safer and more effective hair regrowth in androgenetic alopecia.

The Extract of Thuja Occidentalis Semen Inhibited 5α-Reductase and Androgenetic Alopecia in B6CBAF1/J Hybrid Mice

research The extract of Thujae occidentalis semen inhibited 5α-reductase and androchronogenetic alopecia of B6CBAF1/j hybrid mouse

47 citations , April 2003 in “Journal of dermatological science”

Thujae occidentalis semen extract may help treat male pattern baldness by blocking a hair loss-related enzyme and reducing hair loss in mice.

research Managing patterned hair loss – a hair raising task!

October 2021 in “Cosmoderma”

Hair loss can be managed with treatments like minoxidil, finasteride, and others, but there are still gaps in effectiveness and off-label usage is increasing.

research Efficacy and safety of systemic monotherapy in the management of generalized pustular psoriasis: A systematic review

August 2018 in “Journal of The American Academy of Dermatology”

Different treatments for skin conditions were found to be effective and generally safe, with biologics recommended as the first choice for generalized pustular psoriasis.

research Development and Qualification of a Physiologically Based Pharmacokinetic Model of Finasteride and Minoxidil Following Scalp Application

4 citations , February 2021 in “Journal of Pharmaceutical Sciences”

The model can help predict how finasteride and minoxidil work when applied to the scalp.

A Novel Finasteride 0.25% Topical Solution for Androgenetic Alopecia: Pharmacokinetics and Effects on Plasma Androgen Levels in Healthy Male Volunteers

research A novel finasteride 0.25% topical solution for androgenetic alopecia: pharmacokinetics and effects on plasma androgen levels in healthy male volunteers

50 citations , July 2014 in “International Journal of Clinical Pharmacology and Therapeutics”

New finasteride solution effectively reduces baldness-causing hormone, potentially with fewer side effects.

research Lack of effect of topical finasteride suggests an endocrine role for dihydrotestosterone

12 citations , August 2000 in “Fertility and Sterility”

Topical finasteride doesn't reduce DHT levels, hinting at an endocrine role in hair loss.

research Topical finasteride for the treatment of male androgenetic alopecia and female pattern hair loss: a review of the current literature

13 citations , June 2020 in “Journal of Dermatological Treatment”

Topical finasteride helps regrow hair and reduce hair loss in men and women.

Hair Growth Effects of Oral Administration of Finasteride, a Steroid 5 Alpha-Reductase Inhibitor, Alone and in Combination with Topical Minoxidil in the Balding Stumptail Macaque

research Hair growth effects of oral administration of finasteride, a steroid 5 alpha-reductase inhibitor, alone and in combination with topical minoxidil in the balding stumptail macaque.

34 citations , February 1992 in “The Journal of Clinical Endocrinology and Metabolism”

Finasteride and minoxidil together promote hair growth better than either alone.

research Local and Systemic Reduction by Topical Finasteride or Flutamide of Hamster Flank Organ Size and Enzyme Activity

37 citations , November 1995 in “Journal of Investigative Dermatology”

Topical finasteride and flutamide reduce gland size and enzyme activity, with flutamide being more potent, potentially treating acne, seborrhea, hirsutism, and androgenic alopecia.

Topical Minoxidil Fortified with Finasteride: Maintenance of Hair Density After Replacing Oral Finasteride

research Topical minoxidil fortified with finasteride: An account of maintenance of hair density after replacing oral finasteride

32 citations , January 2015 in “Indian Dermatology Online Journal”

Minoxidil and finasteride combo maintains hair density effectively.

research Topical finasteride in the treatment of androgenic alopecia. Preliminary evaluations after a 16-month therapy course

30 citations , January 1997 in “Journal of Dermatological Treatment”

Topical finasteride helps regrow hair and reduce balding without side effects.

research Topical Finasteride Therapy in Hirsutism

1 citations , January 2001 in “Endocrine Practice”

Topical finasteride may help treat facial hirsutism in women.