Search

for
Search:

Did you mean Topical Immunotherapy?

GlossaryTopical Immunotherapy

deliberately triggers skin immune response to promote hair regrowth

Topical immunotherapy, also known as contact immunotherapy, is a treatment method used primarily for conditions like alopecia areata, where an immune response is deliberately triggered on the skin to promote hair regrowth. This is typically achieved by applying a chemical agent, such as diphencyprone (DPCP), to the affected area, causing a mild allergic reaction that can stimulate hair follicles and potentially lead to hair regrowth.

Related Terms

Sort by

Research

30 / 1000+ results

research Comparative Study between The Efficacy and Safety of Topical Immune Therapy with Diphenylcyclopropenone versus Anthralin in The Treatment of Resistant Alopecia Areata

2 citations , May 2024 in “International Journal of Medical Arts”

Diphenylcyclopropenone (DPCP) is more effective than anthralin for treating resistant alopecia areata.

research Topical immunotherapy in alopecia areata

45 citations , January 2010 in “International journal of trichology”

Topical immunotherapy, especially with DPCP, is effective for treating severe alopecia areata.

research Topical immunotherapy of severe alopecia areata with diphenylcyclopropenone (DPCP): experience in an Iranian population

36 citations , May 2005 in “BMC dermatology”

DPCP is effective for treating severe alopecia areata, but relapse is common.

research Seventeen Cases of Alopecia Areata: Combination of SADBE Topical Immunotherapy with Other Therapies

36 citations , October 2002 in “The Journal of Dermatology”

Combining SADBE with other treatments can help hair regrowth in alopecia areata patients.

research TOPICAL IMMUNOTHERAPY IN DERMATOLOGY

22 citations , March 1999 in “International Journal of Clinical Practice”

Diphencyprone (DCP) is an effective treatment for severe alopecia areata and resistant warts, with some risks.

research Application of Topical Immunotherapy in the Treatment of Alopecia Areata: A Review and Update

20 citations , March 2021 in “Drug design, development and therapy”

Topical immunotherapy can treat alopecia areata, but its effectiveness varies and the exact mechanism is unclear.

research Discoid lupus erythematosus exacerbated by contact dermatitis caused by use of squaric acid dibutylester for topical immunotherapy in a patient with alopecia areata

15 citations , March 2008 in “The Journal of Dermatology”

Topical squaric acid dibutylester worsened discoid lupus erythematosus in a patient.

research Dapsone versus topical immunotherapy in alopecia areata

13 citations , August 1995 in “British Journal of Dermatology”

Topical immunotherapy is more effective than dapsone for treating severe alopecia areata.

Impaired Responses of Peripheral Blood Mononuclear Cells to T-Cell Stimulants in Alopecia Areata Patients with a Poor Response to Topical Immunotherapy

research Impaired responses of peripheral blood mononuclear cells to T-cell stimulants in alopecia areata patients with a poor response to topical immunotherapy

4 citations , July 2008 in “British journal of dermatology/British journal of dermatology, Supplement”

Poor response to topical immunotherapy in alopecia areata patients is linked to impaired cell responses.

research Topical Immunotherapy with Diphenylcyclopropenone in Paediatric Patients with Alopecia Areata—A Retrospective Study of 97 Patients

1 citations , August 2024 in “Skin Health and Disease”

Topical immunotherapy with DPCP led to some hair regrowth in most pediatric alopecia areata patients, especially those with milder cases and longer treatment.

research Treatment outcomes and considerations for topical immunotherapy in patients with alopecia totalis and alopecia universalis

July 2025 in “Frontiers in Medicine”

Topical immunotherapy can help with severe hair loss, but results vary and need personalized, long-term treatment.

Retrospective Analysis of the Effect of Comorbid Atopic Dermatitis on the Treatment Response to Topical Immunotherapy in Pediatric Alopecia Areata Patients

research Retrospective Analysis of the Effect of Comorbid Atopic Dermatitis on the Treatment Response to Topical Immunotherapy in Pediatric Alopecia Areata Patients

January 2024 in “Dermatology practical & conceptual”

Atopic dermatitis in kids with alopecia areata can predict poor response to topical immunotherapy.

research Factors Affecting the Response and Patient Satisfaction of Topical Immunotherapy in Alopecia Areata: A Nationwide Study

January 2024 in “Annals of Dermatology”

DPCP immunotherapy is effective for alopecia areata, and understanding influencing factors can improve treatment and satisfaction.

The Efficacy, Safety, and Recurrence Rate of Diphenylcyclopropenone Topical Immunotherapy for Alopecia Areata: A Systematic Review and Meta-Analysis

research The Efficacy, Safety, and Recurrence Rate of Diphenylcyclopropenone Topical Immunotherapy for Alopecia Areata: A Systemic Review and Meta-Analysis

January 2023 in “Dermatologic therapy”

Diphenylcyclopropenone topical immunotherapy is effective for treating alopecia areata, with some side effects.

research 031 Inducible skin-associated lymphoid tissue (iSALT) is detected in the scalp treated with topical immunotherapy for alopecia areata

May 2017 in “The journal of investigative dermatology/Journal of investigative dermatology”

Topical immunotherapy for alopecia areata may work by creating immune cell clusters in the skin.

research Contact immunotherapy‐resistant alopecia areata totalis/universalis reactive to topical corticosteroid

5 citations , May 2015 in “The Journal of Dermatology”

Topical corticosteroids can help treat severe alopecia areata when other treatments fail.

research Successful Treatment of Multiple Alopecia Areata With Contact Immunotherapy: Supportive Usage of Oral Antihistamine and Topical Corticosteroid

1 citations , December 2017 in “Dermatology - Open Journal”

Alopecia areata was successfully treated with contact immunotherapy, oral antihistamines, and topical corticosteroids.

Comparative Trial on Efficacy of Topical Contact Immunotherapy with Dinitrochlorobenzene and Diphenylcyclopropenone in Alopecia Areata

research Comparative trail on efficacy of topical contact immunotherapy with dinitrochlorobenzene and diphenylcyclopropenone in alopecia areata

July 2021 in “International journal of dermatology, venereology and leprosy sciences”

Diphenylcyclopropenone is more effective and has fewer side effects than dinitrochlorobenzene for treating alopecia areata.

research Severe pustular lesions induced by topical immunotherapy with squaric acid dibutylester for alopecia totalis

1 citations , June 2019 in “Journal of Cutaneous Immunology and Allergy”

Squaric acid dibutylester can cause severe skin reactions in people with allergies.

research Immune Microenvironment of Hair Follicles in Tumor Immunotherapy

February 2026 in “ImmunoTargets and Therapy”

Tumor immunotherapy can cause hair loss by disrupting hair follicle immunity.

research Vitiliginous lesions during contact immunotherapy for alopecia in a patient with autoimmune thyroiditis

2 citations , July 2014 in “Our Dermatology Online”

Contact immunotherapy can cause vitiligo in patients with autoimmune conditions.

research Case Report: Multimodal contact immunotherapy in alopecia areata: long-term clinical experience in the JAK inhibitor era

February 2026 in “Frontiers in Medicine”

Topical immunotherapy is still effective for managing alopecia areata, even with new treatments available.

The Therapeutic Use of Topical Contact Sensitizers in Benign Dermatoses

research Diphencyprone and topical tacrolimus as two topical immunotherapeutic modalities. Are they effective in the treatment of alopecia areata among Egyptian patients? A study using CD4, CD8 and MHC II as markers

13 citations , June 2010 in “Journal of dermatological treatment”

Diphencyprone is effective for treating patchy hair loss in alopecia areata, but tacrolimus is not.