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The study conducted in Kyrgyzstan's Sarychat-Eertash and Naryn Reserves used camera traps to identify mange-like skin lesions in snow leopards and their prey, such as Altai marmots and Siberian ibexes. Since 2012, images have shown signs like alopecia and scabs, with detection rates varying from 0% to 51.07%. Although the lack of biological sampling limits interpretation, these findings highlight concerns about disease transmission among wildlife in these protected areas. The study underscores the need for further research to confirm the causative agents and assess the impact on species conservation in Central Asia's high-mountain ecosystems.

Trichohepatoneurodevelopmental syndrome (THNS) is an ultra-rare disorder characterized by liver dysfunction, hypotonia, developmental delay, coarse hair, and dysmorphic features. This report describes the fifth and sixth cases of THNS from Saudi Arabia, both presenting with these symptoms. Genetic analysis revealed pathogenic variants in the CCDC47 gene: a homozygous variant in Case 1 and two heterozygous variants in Case 2, confirmed to be in trans phase through parental testing. These findings contribute to a stronger gene-disease association and help clarify the clinical phenotype and mutational spectrum of THNS.