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A specific metabolite, not a receptor protein, triggers the production of certain kidney enzymes, but this process is disrupted in mice with a mutation causing testicular feminization.

CCT128930 is a promising new drug that effectively targets and inhibits a cancer-related protein, showing potential for cancer treatment.

Researchers created a cell line to study hair growth and found specific genes affected by dihydrotestosterone.

Modified β-catenin causes different effects in hair and skin cells, leading to cysts or tumors.

Retinoic acid and DMSO improve gene delivery to mouse skin for potential hair and skin disease treatment.

A virus protein can activate a pathway that may lead to abnormal hair follicle development.

Activating cAMP and ATP improves hair growth and strength.

Modified β-catenin can cause different effects in mouse skin cells, leading to cysts or tumors depending on the cell type.

Cells with active Wnt signaling are less likely to turn into cancer when exposed to a cancer-causing gene.

Activating ER-β, not ER-α, improves skin cell growth and wound healing.

New mouse models help study melanocytic cells for melanoma research.

Injecting lentiviral vectors into early gestation mice effectively targets skin stem cells for potential gene therapy.

Overexpressing IGF-1 in mice leads to skin abnormalities and tumors.

Activating TRPV4 in skin cells helps regrow hair in mice, possibly offering a treatment for hair loss.

Controlling transposable elements is crucial for successful tissue regeneration.

Mutations at Val-889 and Arg-752 disrupt key interactions in androgen receptor dimerization.

Akt2 protein is essential for normal cell division in early mouse embryos.

Temporary activation of β-catenin can create new hair follicles, but ongoing activation is needed to keep hair follicle tumors.

In vitro bioassays are better than traditional methods for measuring androgen activity but aren't ready for routine use yet.

Activin B can boost hair growth by promoting cell proliferation and cell cycle progression.

Activin B helps start and grow hair follicles in mice.

A reliable model for screening type II 5α-reductase inhibitors was created and validated.

A new 3-D bioreactor system improves drug screening and reduces animal testing.

Stem cells control their future role by changing ERK signal timing, affecting tissue regeneration and cancer.

The TCL1 transgenic mouse model is useful for understanding human B-cell leukemia and testing new treatments.

LGD1069 effectively prevents breast tumors in mice without toxicity.

SSAT is a key enzyme affecting cell growth and metabolism, with potential but risky use in disease treatment.