426 citations
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August 2014 in “Nature Medicine” Skin stem cells interacting with their environment is crucial for maintaining and regenerating skin and hair, and understanding this can help develop new treatments for skin and hair disorders.
41 citations
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April 2019 in “PLOS genetics” CD34+ and CD34- melanocyte stem cells have different regenerative abilities.
31 citations
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August 2021 in “Stem Cell Research & Therapy” The conclusion is that understanding how hair follicle stem cells live or die is important for maintaining healthy tissue and repairing injuries, and could help treat hair loss, but there are still challenges to overcome.
9 citations
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September 2013 in “Journal of histochemistry and cytochemistry/The journal of histochemistry and cytochemistry” Matriptase is highly active in hair follicles and sebaceous glands, especially during hair growth phases.
6 citations
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January 2015 in “Journal of regenerative medicine & tissue engineering” The review concludes that innovations in regenerative medicine, tissue engineering, and developmental biology are essential for effective tissue repair and organ transplants.
September 2025 in “Science Advances” PADI4 enzyme slows down cell growth in developing hair follicles.
53 citations
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January 2012 in “Developmental Biology” EGFR signaling is essential for ear cell regeneration in both birds and mammals.
7 citations
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January 2020 in “International Journal of Molecular Sciences” Low-frequency electromagnetic fields can boost molecules related to hair growth in human skin cells.
3 citations
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December 2024 in “Stem Cell Reports” Low fucosylation boosts stem cell growth in the eye.
May 2026 in “Cell Reports Medicine” FR-1 reduces skin scarring and promotes healing without harmful effects.
October 2025 in “Bioactive Materials” Combining traditional Chinese medicine with microneedles shows promise for effectively treating skin diseases with fewer side effects.
November 2023 in “International Journal of Medical Sciences” New regenerative medicine-based therapies for hair loss look promising but need more clinical validation.
Lhx2 is essential for effective Sonic Hedgehog signaling in early retinal development.
50 citations
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April 2021 in “Frontiers in Immunology” New therapies targeting skin neuroimmune interactions could treat neuropathic pain.
44 citations
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June 2023 in “Cell Reports” IL-1 promotes fat cell growth in skin, while WNT inhibits it and encourages scar formation.
21 citations
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October 2022 in “International Journal of Molecular Sciences” Quercitrin may help treat Alzheimer's by boosting brain cell signaling without causing tumors.
11 citations
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April 2023 in “Frontiers in Pharmacology” Integrating biological networks improves drug repurposing and ADR prediction.
5 citations
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August 2025 in “Journal of Radiation Research” Understanding skin reactions to radiation has improved, helping to reduce injuries and prevent skin cancer.
5 citations
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April 2024 in “Biology” Improving human hair follicle models is crucial for better hair loss treatments.
3 citations
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July 2025 in “Gels” Engineered protein hydrogels improve medical treatments by mimicking natural body structures.
April 2026 in “International Journal of Molecular Sciences” Targeting non-Smad pathways in TGF-β signaling may improve keloid treatment.
91 citations
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June 2011 in “The EMBO Journal” TCF/Lef1 activity is essential for proper skin cell development and renewal.
39 citations
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January 2020 in “Frontiers in Genetics” PDGFC gene may help select goats with desirable curly wool traits.
28 citations
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April 2024 in “Immunity” CD80 on skin stem cells helps expand Treg cells to aid wound healing.
21 citations
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July 2018 in “International Journal of Molecular Sciences” Foxn1 is crucial for skin development and healing, and altering its expression may aid regenerative medicine.
4 citations
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June 2023 in “Frontiers in Aging” Improving blood flow and oxygen levels in middle age may help prevent age-related diseases.
2 citations
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December 2025 in “Cosmetics” Proper scalp care can improve hair health and delay ageing signs.
July 2026 in “Pharmaceuticals” Aging and chronic diseases impair muscle repair, but integrated therapies like exercise and gene editing may help.
March 2026 in “Preprints.org” The combined stem cell secretome in the skin care product effectively reduces inflammation and promotes tissue regeneration.
5 citations
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June 2024 in “Developmental Cell” Activating TRPV1 can boost hair growth by involving neurons, macrophages, and fibroblasts.