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The new compounds moderately block a specific enzyme and strongly counteract a male hormone, suggesting potential for treating certain male-related health conditions.

Gray hair can potentially be reversed, leading to new treatments.

Rejection sensitivity can lead to more loneliness and problematic internet use, but self-control can help reduce this effect.

PRC2 is not essential for hair follicle stem cell maintenance or hair growth.

Scientists found a specific group of itch-sensing nerve cells in mice important for feeling itch but not for sensing heat or touch.

Certain defective glucocorticoid receptor mutants move faster inside cell nuclei and work less effectively.

Neurosteroids regulate synaptic inhibition in the spinal cord and may help manage spinal pain.

Progesterone reduces anxiety without needing progesterone receptors.

Retinoic acid can either maintain stem cells or make them specialize, depending on the cell type.

Some new progesterone derivatives are better at blocking testosterone conversion than a common drug.

Different miRNAs in Rex rabbit skin affect cell processes and hair growth.

Social isolation makes rats more sensitive to alcohol's effects on the brain.

Inhibiting AP1 in mice skin causes structural changes and weakens the skin barrier.

SETDB1 is essential for controlling DNA methylation, silencing retrotransposons, and maintaining skin cell health, with its absence leading to skin inflammation and hair loss.

TGF-β2 helps activate hair follicle stem cells by counteracting BMP signals.

Key genes can rewire networks, changing skin appendage types.

Hairless protein and putrescine regulate each other, affecting hair growth and skin balance.

Androgen receptor activity is influenced by hormones, co-factors, modifications, and mutations.

Antidepressants, 5α-reductase inhibitors, and isotretinoin can cause long-lasting sexual dysfunction.

Finasteride may help reduce COVID-19 infection by altering a key gene.

Epitestosterone may act as a weak antiandrogen and can inhibit an enzyme involved in testosterone metabolism.

The new progesterone derivatives effectively inhibit 5α-reductase and bind to the androgen receptor.

Prostate cancer cells can make their own androgens to activate the androgen receptor, and treatments like abiraterone may increase this ability, suggesting new therapies should target the entire steroid-making pathway.

Overexpressing the glucocorticoid receptor in mice leads to abnormal skin development and reduced inflammation.

Meis2 is essential for touch sensation and nerve function in mice.

Some men's prostate tissues have low enzyme levels due to genetic changes, possibly affecting treatment for prostate enlargement.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

Progesterone's anesthetic effects don't rely on progesterone receptors.