April 2016 in “Journal of Investigative Dermatology” FOL-005, a new substance, was found to reduce hair growth without toxicity when injected into skin, suggesting it could be used to treat excessive hair growth.
4 citations
,
April 2019 in “Cell Stem Cell” Certain immune cells in the skin can stop hair from growing.
Retinoids can help treat skin pigmentation disorders by affecting melanin production.
26 citations
,
April 1977 in “PubMed” Minoxidil, a blood pressure drug, can cause excessive hair growth, but this can be successfully treated with a hair removal agent called calcium thioglycolate.
1 citations
,
January 2015 in “Genetics and Molecular Research” Stopping S100A3 activity slows down hair growth in mice.
10 citations
,
February 2008 in “Photochemistry and photobiology” Vitamin D receptor can control the hairless gene linked to hair loss even without vitamin D.
1 citations
,
May 2015 in “Experimental Dermatology” Overactive Stat3 in mouse skin causes hair loss and cell structure damage.
52 citations
,
January 2003 in “Journal of Investigative Dermatology” Thrombospondin-1 is crucial for hair follicle regression and reduced blood vessel growth during the catagen phase.
40 citations
,
March 2003 in “The journal of small animal practice/Journal of small animal practice” Trilostane helped a dog with an adrenal tumor feel better and stay healthy.
24 citations
,
December 2011 in “International Journal of Cancer” PTH-CBD agonists may help regrow hair after chemotherapy.
July 2024 in “Forum Dermatologicum”
Blocking 11β-HSD1 reduces stress hormone damage in hair growth cells.
1 citations
,
August 2024 in “Transgenic Research” Activated β-catenin affects hair growth and skin thickness, and changes are reversible.
13 citations
,
January 2017 in “Chemical & Pharmaceutical Bulletin” Certain compounds, especially those with a propionic substituent, could potentially be new treatments for hair loss and similar disorders.
November 2025 in “Journal of Investigative Dermatology”
451 citations
,
March 2005 in “Endocrine Reviews” The enzyme steroid sulfatase is linked to breast cancer and other conditions, and inhibitors are being developed for treatment.
3 citations
,
May 2018 in “Psychiatry and Clinical Psychopharmacology” N-acetylcysteine may help treat trichotillomania.
February 2026 in “Cureus” Ciclosporin can cause excessive hair growth even with testosterone blockers.
37 citations
,
October 2017 in “Clinical and Experimental Dermatology” Oral tofacitinib shows promise in treating atopic dermatitis and alopecia areata, but only slight improvement in vitiligo.
Simvastatin and Luteolin effectively reduce hair loss and promote hair growth.
26 citations
,
June 2003 in “PubMed” Alpha-difluoromethylornithine prevents cancer in mice but causes hair loss.
Blocking the Mitochondrial Pyruvate Carrier causes stress in hair follicles, which can be reduced by an ISR inhibitor.
August 1993 in “Journal of Dermatological Science” Cyclosporin and minoxidil promote hair growth.
3 citations
,
October 1993 in “Endocrinology” 3 citations
,
January 1990 in “Cancer chemotherapy and pharmacology” Topical thiols may prevent hair loss caused by certain chemotherapy drugs.
8 citations
,
March 2002 in “Archiv Der Pharmazie” The compound 4c effectively inhibits the enzyme linked to hair loss.
September 2022 in “Journal of Ayub Medical College Abbottabad” Steroid injections are more effective than platelet rich plasma for treating patchy hair loss.
3 citations
,
January 2022 in “Neurotoxicity Research” Botulinum toxin may help reduce stress-related hair loss.
4 citations
,
May 2022 in “Genes & Diseases” 27 citations
,
March 2008 in “Cell stress & chaperones” Localized heat or specific injections can prevent chemotherapy-induced hair loss without affecting cancer treatment.