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GlossaryTumor Growth

abnormal cell proliferation forming a mass, potentially cancerous

Tumor growth refers to the process by which abnormal cells proliferate uncontrollably, forming a mass or lump known as a tumor. This can occur in any tissue of the body and can be benign (non-cancerous) or malignant (cancerous), with malignant tumors having the potential to invade nearby tissues and spread to other parts of the body (metastasis). Understanding the mechanisms behind tumor growth is crucial for developing effective cancer treatments.

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research Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

53 citations , July 2009 in “Cancer Research”

Blocking certain proteins can reduce skin inflammation caused by cancer treatment.

research Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

March 2023

TNFα and interleukin-1 blockers reduce skin inflammation from EGFR antibody therapy.

research Data from Tumor Necrosis Factor-α and Interleukin-1 Antagonists Alleviate Inflammatory Skin Changes Associated with Epidermal Growth Factor Receptor Antibody Therapy in Mice

March 2023

TNFα and interleukin-1 blockers reduce skin inflammation from EGFR antibody therapy.

research Alopesi areata hastalarında serum interferon-gama, tümör nekrozis faktör-alfa, interlökin-13, interlökin-17 ve transforming growth faktör-beta düzeylerinin değerlendirilmesi

January 2016

Atopy and altered T cell functions contribute to Alopecia Areata.

research Expression of transforming growth factor-β_1 and tumor necrosis factor-α in mice with radiationinduced pulmonary injury

January 2010 in “Zhongguo xiandai yixue/Zhongguo xiandai yixue zazhi”

TGF-β1 and TNF-α contribute to lung damage after radiation.

research Regulation of Hematopoietic Cell Development and Hair Growth in Mouse Models: Expression Analysis of Tudor-SN and Polyamine-Regulated Proteins

November 2013 in “Tampere University Institutional Repository (Tampere University)”

Tudor-SN is important for immune cells, and polyamines can promote hair growth.

Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors

research Expression Patterns of Gli-1, Pleckstrin Homology-Like Domain, Family A, Member 1, Transforming Growth Factor-β1/β2, and p63 in Sebaceous and Follicular Tumors

8 citations , January 2014 in “Annals of Dermatology”

The research suggests that p63 and TGF-β1 may help determine tumor type and malignancy in hair follicle and sebaceous tumors.

research Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice

147 citations , April 1997 in “Oncogene”

Overexpressing IGF-1 in mice leads to skin abnormalities and tumors.

research Skin stem cells and tumor growth : functions of collagen XVIII in hair follicle cycling and skin cancer, and Bmx tyrosine kinase in tumor angiogenesis

3 citations , January 2014

Collagen XVIII and Bmx tyrosine kinase are important for hair growth and skin cancer development.

research Original synthetic monophenolic antioxidant with combined effect inhibits tumor growth in vivo

2 citations , January 2025 in “Сибирский научный медицинский журнал”

TS-13 effectively stops tumor growth and reduces chemotherapy side effects.

research 647 NLRP1 promotes tumor growth by enhancing inflammasome activation and suppressing caspase-3 activity in human melanoma

1 citations , April 2016 in “Journal of Investigative Dermatology”

NLRP1 helps melanoma tumors grow by boosting inflammasome activation and reducing caspase-3 activity.

research Growth inhibition of mouse skin tumor by serine protease inhibitor ONO-3403.

1 citations , September 2001 in “PubMed”

ONO-3403 effectively reduces mouse skin tumor growth without side effects.

research Rooster feathering, androgenic alopecia, and hormone-dependent tumor growth: What is in common?

23 citations , December 2004 in “Differentiation”

Sex hormones affect hair and feather growth and may help manage alopecia and hormone-dependent cancers.

research Protection against cyclophosphamide‐induced alopecia and inhibition of mammary tumor growth by topical 1,25‐dihydroxyvitamin D3 in mice

1 citations , January 1998 in “International journal of cancer”

Rubbing vitamin D3 on skin can help prevent hair loss from chemotherapy and slow breast tumor growth in mice.

research Activated Polyamine Catabolism Depletes Acetyl-CoA Pools and Suppresses Prostate Tumor Growth in TRAMP Mice

91 citations , July 2004 in “Journal of Biological Chemistry”

Overexpressing SSAT enzyme reduces prostate tumor growth in mice.

research Single-cell analysis of basal cell carcinoma reveals heat shock proteins promote tumor growth in response to WNT5A-mediated inflammatory signals

1 citations , October 2021 in “bioRxiv (Cold Spring Harbor Laboratory)”

Heat shock proteins help basal cell carcinoma grow by responding to inflammation signals.

research Roles of tumor suppressors in regulating tumor-associated inflammation

44 citations , September 2014 in “Cell Death & Differentiation”

Tumor suppressors help control inflammation in cancer and restoring their function could lead to new treatments.

research Tumor Promotion in Skin: Are Active Oxygen Species Involved?

10 citations , January 1985 in “Elsevier eBooks”

Active oxygen species might be involved in skin tumor growth, but their exact role is unclear.

research The role of fibroblast growth factor receptor 2b in skin homeostasis and cancer development

125 citations , February 2007 in “The EMBO Journal”

Fgfr2b helps maintain healthy skin and prevent cancer.

research Cytokines and growth factors influence hair growth in vitro. Possible implications for the pathogenesis and treatment of alopecia areata

91 citations , March 1996 in “Archives of Dermatological Research”

Certain cytokines and growth factors can inhibit hair growth and may affect alopecia areata.

research Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of Retinoblastoma and Trp53 Tumor Suppressors

64 citations , February 2008 in “Cancer Research”

Inactivating both p53 and Rb genes in mice speeds up aggressive skin cancer development.

research Identification of clustered cells in human hair follicle responsible for MMP‐9 gelatinolytic activity: consequences for the regulation of hair growth

27 citations , June 2001 in “International Journal of Dermatology”

MMP-9 increase in hair follicles may lead to hair loss.

research Identification and characterization of an antisense RNA transcript (gfg) from the human basic fibroblast growth factor gene.

24 citations , July 1994 in “Molecular Endocrinology”

Researchers found an RNA transcript that might help control a growth factor linked to tumor development.

research Narrow-band red LED light promotes mouse hair growth through paracrine growth factors from dermal papilla

23 citations , September 2011 in “Journal of Dermatological Science”

Red LED light helps mouse hair grow by increasing growth factors from skin cells.

research The Tumor Necrosis Factor-α Level in Platelet-Rich Plasma Might Be Associated with Treatment Outcome in Patients with Interstitial Cystitis/Bladder Pain Syndrome or Recurrent Urinary Tract Infection

8 citations , December 2023 in “International Journal of Molecular Sciences”

Lower TNF-α levels in PRP may predict better treatment outcomes for bladder conditions.

Pinus Thunbergii Bark Extract Rich in Flavonoids Promotes Hair Growth in Dorsal Skin by Regulating Inflammatory Cytokines and Increasing Growth Factors in Mice

research Pinus thunbergii bark extract rich in flavonoids promotes hair growth in dorsal skin by regulating inflammatory cytokines and increasing growth factors in mice

5 citations , January 2022 in “Molecular Medicine Reports”

Pine bark extract helps mice grow hair by reducing inflammation and boosting growth factors.

Collagen Hydrolysate from Mozambique Tilapia Scales Improves Hair and Skin Health

research Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors

2 citations , August 2023 in “Marine drugs”

Collagen from tilapia scales may improve hair and skin health by reducing stress and inflammation and encouraging hair growth.

research Experiment on the effect of Artemisia sieversiana extract on hair loss prevention and cell growth

1 citations , March 2022 in “Daehanhanuihakoeji”

Artemisia sieversiana extract may help prevent hair loss and promote hair growth.

research Aqueous Dispersion of Unmodified Fullerene C60: Stimulation of Hair Growth and Study of a New Molecular Target for Interaction

September 2025 in “International Journal of Molecular Sciences”

Unmodified fullerene C60 promotes hair growth and may help treat hair loss.

research Data from Spontaneous Squamous Cell Carcinoma Induced by the Somatic Inactivation of <i>Retinoblastoma</i> and <i>Trp53</i> Tumor Suppressors

March 2023

Loss of the p53 gene alone causes tumors, and losing both p53 and Rb genes speeds up aggressive skin cancer.