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research Overexpression of protein kinase C-α in the epidermis of transgenic mice results in striking alterations in phorbol ester-induced inflammation and COX-2, MIP-2 and TNF-α expression but not tumor promotion

135 citations , October 1999 in “Journal of Cell Science”

Overexpressing PKCα in mice skin increases inflammation but doesn't affect tumor growth.

research Transgenic mice overexpressing protein kinase C epsilon in their epidermis exhibit reduced papilloma burden but enhanced carcinoma formation after tumor promotion.

99 citations , February 2000 in “PubMed”

Overexpressing PKCepsilon in mice reduces papillomas but increases carcinomas.

research Induction of dark keratinocytes by 12-O-tetradecanoyl-phorbol-13-acetate and mezerein as an indicator of tumor-promoting efficiency

77 citations , January 1980 in “Carcinogenesis”

TPA is about 50 times more effective at promoting tumors than MZ.

research Tumor Promotion in Skin: Are Active Oxygen Species Involved?

10 citations , January 1985 in “Elsevier eBooks”

Active oxygen species might be involved in skin tumor growth, but their exact role is unclear.

research Impact of mTORC1 inhibition on keratinocyte proliferation during skin tumor promotion in wild‐type and BK5.Akt^WT mice

8 citations , September 2013 in “Molecular carcinogenesis”

Rapamycin reduces skin cell growth and tumor development by affecting cell signaling in mice.

research Abstract 5357: Targeting mTORC1 suppresses proliferation of keratinocyte stem cells and inhibits skin tumor promotion in mice

October 2014 in “Cancer research”

Blocking mTORC1 reduces skin tumor growth in mice.

research Conversion of C57Bl/6 mice from a tumor promotion–resistant to a –sensitive phenotype by enhanced ornithine decarboxylase expression

September 1999 in “Molecular Carcinogenesis”

Increased ODC expression makes normally tumor-resistant mice more prone to tumor development.

research Short-Term Biomarkers of Cigarette Smoke Condensate Tumor Promoting Potential in Mouse Skin

11 citations , October 2005 in “Toxicological Sciences”

Cigarette smoke condensates increase tumor-promoting markers in mouse skin, especially around hair follicles.

research 17b-Estradiol is Abundant in Skin and Regulates the Hair Follicle Cycle and Mirex Tumor Promotion

January 2002 in “NCSU Libraries Repository (North Carolina State University Libraries)”

17b-Estradiol in skin affects hair growth and tumor promotion.

research Reconstitution of human skin in vitro using readily available sources: Novel studies of tumour promotion

August 1994 in “Toxicology in Vitro”

A lab model of human skin was created to study skin tumor promoters without using actual human skin.

research Hair Growth Promoting Effect of Thuja orientalis Ethanol Extracts on Hair Loss-induced DBA1J Mice

1 citations , January 2004 in “Journal of Physiology & Pathology in Korean Medicine”

Thuja orientalis extract significantly promotes hair growth in mice with hair loss.

research Patched1 Functions as a Gatekeeper by Promoting Cell Cycle Progression

176 citations , February 2006 in “Cancer Research”

Patched1 helps prevent tumors by controlling cell growth.

Collagen Hydrolysate from Mozambique Tilapia Scales Improves Hair and Skin Health

research Collagen Hydrolysate from the Scales of Mozambique Tilapia (Oreochromis mossambicus) Improve Hair and Skin Health by Alleviating Oxidative Stress and Inflammation and Promoting Hair Growth and Extracellular Matrix Factors

2 citations , August 2023 in “Marine drugs”

Collagen from tilapia scales may improve hair and skin health by reducing stress and inflammation and encouraging hair growth.

research Relation of Skin Polyamines to the Hairless Phenotype in Transgenic Mice Overexpressing Spermidine/Spermine N1-Acetyltransferase

54 citations , May 2001 in “Journal of Investigative Dermatology”

Excessive putrescine causes hair loss in transgenic mice by disrupting hair follicle development.

research Mitogen‐regulated protein/proliferin mRNA induction following single applications of tumor promoters to murine skin

May 2005 in “Molecular Carcinogenesis”

mrp/plf-mRNA can indicate tumor-promoting effects in skin.

research Promotion of Skin Carcinogenesis by Dimethylarsinic Acid in Keratin (K6)/ODC Transgenic Mice

48 citations , June 2000 in “Japanese Journal of Cancer Research”

Dimethylarsinic acid speeds up skin tumor growth in certain mice.

research Protein kinase Cepsilon is linked to 12-O-tetradecanoylphorbol-13-acetate-induced tumor necrosis factor-alpha ectodomain shedding and the development of metastatic squamous cell carcinoma in protein kinase Cepsilon transgenic mice.

79 citations , October 2003 in “PubMed”

Overexpression of PKCepsilon leads to increased TNFalpha, promoting metastatic squamous cell carcinoma in mice.

research Role of the bone morphogenetic protein signalling in skin carcinogenesis. Effect of transgenic overexpression of BMP antognist Noggin on skin tumour development; molecular mechanisms underlying tumour suppressive role of the BMP signalling in skin.

January 2009 in “Bradford Scholars (University of Bradford)”

BMP signaling helps prevent skin tumors by blocking cancer-promoting pathways.

research Freeze‐Drying Tumor Tissues Derived Bio‐Patches With Hair Melanin Nanoparticles Integration for Wound Healing

April 2026 in “Small”

The bio-patch improves wound healing by reducing stress, inflammation, and promoting blood vessel growth.

research Single dose gamma irradiation induced angiogenesis in rat skin hair follicles

3 citations , October 2020 in “Internatuinal Journal of Radiation Research”

Gamma irradiation can stimulate hair growth by promoting new blood vessel formation.

Efficacy and Mechanism of Topical Shen Bai Hair Growing Decoction Against Androgenetic Alopecia

research Study on the Efficacy and Potential Mechanism of Topical Shen Bai Hair Growing Decoction against Androgenetic Alopecia Based on Ultrahigh Performance Liquid Chromatography Quadrupole Time-of-Flight Mass Spectrometry and RNA-seq

February 2024 in “ACS Omega”

The Shen Bai Hair Growing Decoction may help treat hair loss by promoting hair growth and reducing inflammation.

research ERG induces androgen receptor-mediated regulation of SOX9 in prostate cancer

224 citations , February 2013 in “The Journal of clinical investigation/The journal of clinical investigation”

ERG increases SOX9, promoting prostate cancer growth and invasion.

research Hinokitiol, a Natural Tropolone Derivative, Inhibits TNF-α Production in LPS-Activated Macrophages via Suppression of NF-κB

54 citations , June 2008 in “Planta Medica”

Hinokitiol may help treat hair loss by reducing inflammation and promoting hair growth.

research Tumor suppressor activity of ODC antizyme in MEK-driven skin tumorigenesis

37 citations , January 2006 in “Carcinogenesis”

Antizyme slows skin tumor growth by reducing cell growth in mice.

research GLI2 Is Expressed in Normal Human Epidermis and BCC and Induces GLI1 Expression by Binding to its Promoter

171 citations , June 2004 in “Journal of Investigative Dermatology”

GLI2 activates GLI1, promoting skin tumor growth and hair development.

research The Paradox of p53: What, How, and Why?

64 citations , July 2016 in “Cold Spring Harbor Perspectives in Medicine”

The p53 protein has complex, sometimes contradictory functions, including tumor suppression and promoting cell survival.

Dual Aspects of B Cells in Tumor Immunity: Positive and Negative Regulation Against B16 Melanoma

research Dual aspects of B cells in tumor immunity; B cells are capable of positive and negative regulation for tumor immunity against B16 melanoma

April 2017 in “Journal of Dermatological Science”

B cells can both help and hinder the body's defense against melanoma.

research Overexpression of insulin-like growth factor-1 induces hyperplasia, dermal abnormalities, and spontaneous tumor formation in transgenic mice

147 citations , April 1997 in “Oncogene”

Overexpressing IGF-1 in mice leads to skin abnormalities and tumors.

research UTMD Enhances Targeting of Diclofenac and Doxil® to Boost Tumor Immunotherapy

July 2025 in “Ultrasound in Medicine & Biology”

UTMD with diclofenac and Doxil® improves cancer treatment by boosting immune response and reducing tumor-supporting cells.

research Removing all obstacles: A critical role for p53 in promoting tissue renewal

30 citations , April 2010 in “Cell Cycle”

The gene p53 is crucial for removing damaged cells to allow for healthy tissue renewal.