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GlossaryUnsaturated Fatty Acids

contain one or more double bonds in their hydrocarbon chains

Unsaturated fatty acids (UFAs) are a type of fat molecule that contains one or more double bonds between carbon atoms in their hydrocarbon chain. These double bonds create kinks in the chain, preventing the molecules from packing tightly together, which is why unsaturated fats are typically liquid at room temperature. They are considered healthier than saturated fats and are found in foods like olive oil, nuts, and fish.

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Transfollicular Enhancement of Gel Containing Cationic Niosomes Loaded with Unsaturated Fatty Acids in Rice Bran Semi-Purified Fraction

research Transfollicular enhancement of gel containing cationic niosomes loaded with unsaturated fatty acids in rice (Oryza sativa) bran semi-purified fraction

21 citations , April 2012 in “European Journal of Pharmaceutics and Biopharmaceutics”

The gel with special fat-loaded particles from rice bran could be an effective skin treatment for hair loss.

research Distribution of Glycolipid and Unsaturated Fatty Acids in Human Hair

18 citations , August 2014 in “Lipids”

Human hair has more unsaturated fats inside than on the surface, and certain lipids may help bind the outer and inner layers together.

research Omega-6 highly unsaturated fatty acids in Leydig cells facilitate male sex hormone production

7 citations , September 2022 in “Communications biology”

Omega-6 fats in certain cells boost male hormone production.

research The fatty acids and the skin: a focus on the n-6 family of unsaturated fatty acids

1 citations , January 2012 in “Human health handbooks”

Linoleic acid is important for healthy skin, and while most people get enough from their diet, not having enough can cause skin and hair problems.

research The fatty acids and the skin: a focus on the n-6 family of unsaturated fatty acids

November 2012

Linoleic acid is essential for healthy skin, and while deficiency is rare in Western societies, it can cause dry, scaly skin and hair loss.

research Structural variation-driven FADS2P1 expression modulates hair trait diversity through unsaturated fatty acid metabolism in goats

March 2026 in “Journal of genetics and genomics/Journal of Genetics and Genomics”

research Para rubber seed oil and its fatty acids alleviate photoaging and maintain cell homeostasis

1 citations , July 2024 in “International Journal of Cosmetic Science”

Para rubber seed oil helps protect skin from aging caused by sunlight.

research Sebaceous gland abnormalities in fatty acyl CoA reductase 2 (Far2) null mice result in primary cicatricial alopecia

14 citations , October 2018 in “PloS one”

Deleting the Far2 gene in mice causes sebaceous gland issues and patchy hair loss.

research Influence of dietary linoleic acid (18:2, n6) on the effects of hyperthyroidism in Mus musculus

January 1992 in “Research Online (University of Wollongong)”

Dietary linoleic acid may help reduce hyperthyroidism effects.

Phytochemical Analyses of Ziziphus Jujuba Mill. Var. Spinosa Seed by Ultrahigh Performance Liquid Chromatography-Tandem Mass Spectrometry and Gas Chromatography-Mass Spectrometry

research Phytochemical analyses of Ziziphus jujuba Mill. var. spinosa seed by ultrahigh performance liquid chromatography-tandem mass spectrometry and gas chromatography-mass spectrometry

38 citations , January 2013 in “Analyst”

The study found that Ziziphus jujuba seeds contain beneficial compounds for treating insomnia and anxiety and that the methods used are effective for assessing their quality.

research 5α-Reductase type 1 inhibition of Oryza sativa bran extract prepared by supercritical carbon dioxide fluid

22 citations , August 2011 in “Journal of Supercritical Fluids”

Rice bran extract might help prevent hair loss.

research Red ginseng (Panax ginseng Meyer) oil: A comprehensive review of extraction technologies, chemical composition, health benefits, molecular mechanisms, and safety

11 citations , December 2021 in “Journal of Ginseng Research/Journal of ginseng research”

Red ginseng oil is believed to have various health benefits and is safe, but more research is needed to fully understand how it works.

research Anti-Hair Loss Potential of Perilla Seed Extracts: In Vitro Molecular Insights from Supercritical Fluid Extraction

July 2025 in “Foods”

Perilla seed extract may help prevent hair loss better than some standard treatments.

research Associations between ionomic profile and metabolic abnormalities in a murine model of sodium sulfide induced alopecia areata

May 2025 in “Frontiers in Pharmacology”

Targeting gut microbiome and metabolome may help treat autoimmune skin diseases like alopecia areata.

research Optimization of Bear Oil Extraction Process and Hair Growth Activity

March 2024 in “Molecules/Molecules online/Molecules annual”

Enzymatically extracted bear oil has more unsaturated fats and significantly increases hair growth in mice.

research From Plants to Wound Dressing and Transdermal Delivery of Bioactive Compounds

July 2023 in “Plants”

Plant-based compounds can improve wound dressings and skin medication delivery.

research 859 Building a functional niche for hair follicle stem cells

April 2017 in “Journal of Investigative Dermatology”

Deleting the CRIF1 gene in mice disrupts skin and hair formation, certain proteins affect hair growth, a new compound may improve skin and hair health, blood cell-derived stem cells can create skin-like structures, and hair follicle stem cells come from embryonic cells needing specific signals for development.

research Therapy of alopecia

January 2005 in “Farmaceutski glasnik”

Minoxidil and finasteride are key treatments for hair loss.

Human Hair Follicle Regeneration With Trichogenic Human Dermal Papilla Precursor Cells Derived From Induced Pluripotent Stem Cells

research 857 Human hair follicle regeneration with trichogenic human dermal papilla precursor cells derived from induced pluripotent stem cells

April 2017 in “Journal of Investigative Dermatology”

Stem cells can create hair follicles, potentially treating permanent hair loss, and healthy skin and hair depend on mitochondrial function and special fats.

research Serum Metabolomics Study of Polycystic Ovary Syndrome Based on Liquid Chromatography–Mass Spectrometry

71 citations , January 2014 in “Journal of Proteome Research”

Women with PCOS have different levels of certain fats and proteins in their blood, which could help diagnose the condition.

research The Role of PPARβ/δ-Related Lipid Metabolism in High-Altitude Adaptation of Yak Coat Based on Proteomics and Metabolomics

November 2025 in “Cells”

PPARβ/δ helps yaks adapt to high altitudes by regulating lipid metabolism in their coats.

research Sphingolipids of the Murine Hair

1 citations , January 2012 in “Journal of The Society of Japanese Women Scientists”

Murine hair has specific types of ceramides and glucosylceramides but lacks acylceramides.

research Penetration of oils into hair

June 2024 in “International Journal of Cosmetic Science”

Plant oils like coconut, camellia, and safflower can penetrate hair, making it stronger and softer.

research National Lipid Association Recommendations for Patient-Centered Management of Dyslipidemia: Part 2

391 citations , September 2015 in “Journal of Clinical Lipidology”

The guidelines suggest lifestyle changes, diet adjustments, and personalized medication to manage dyslipidemia and reduce heart disease risk.

research NIGELLA SATIVA L.: AN OVERVIEW

December 2024 in “Ankara Universitesi Eczacilik Fakultesi Dergisi”

Black cumin has many health benefits and potential for new medicines.

Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane-Induced Dystrophy and Redirect Polyunsaturated Fatty Acid Metabolism Toward β-Oxidation

research Annurca Apple Polyphenols Protect Murine Hair Follicles from Taxane Induced Dystrophy and Hijacks Polyunsaturated Fatty Acid Metabolism toward β-Oxidation

19 citations , November 2018 in “Nutrients”

Annurca apple extract may protect mouse hair from damage by chemotherapy and could help treat hair loss without promoting cancer growth.

research Fatty acids and related lipid mediators in the regulation of cutaneous inflammation

28 citations , January 2018 in “Biochemical Society Transactions”

Certain fats in the skin help control inflammation and health, and changing these fats through diet or supplements might treat skin inflammation.

research Diagnosing Essential Fatty Acid Deficiency

18 citations , June 1998 in “Circulation”

Mild essential fatty acid deficiency can cause health issues and is worsened by low-fat diets.

ERK1/2 Pathway Involvement in Enhancement of Fatty Acids from Phaeodactylum Tricornutum Extract on Hair Follicle Cell Proliferation

research ERK1/2 Pathway Is Involved in the Enhancement of Fatty Acids from Phaeodactylum tricornutum Extract (PTE) on Hair Follicle Cell Proliferation

2 citations , January 2020 in “BioMed Research International”

Phaeodactylum tricornutum extract helps hair follicle cells grow by activating the ERK1/2 pathway.

research Evaluation of the Topical use of Essential Fatty Acids in Rabbits with Skin Disorders

January 2021 in “Research journal for veterinary practitioners”

The document does not determine if essential fatty acids improve rabbit skin health.