research A concise review- Development of an analytical method and validation of dutasteride
New methods for measuring dutasteride are effective and reliable.
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research Isotope Dilution-Based Targeted and Nontargeted Carbonyl Neurosteroid/Steroid Profiling
Researchers created a new method to measure brain steroids, finding higher levels of certain steroids and changes due to a drug.
research Revisiting hyper- and hypo-androgenism by tandem mass spectrometry
The document concludes that using LC-MS/MS for measuring androgens is more accurate than older methods, but it needs careful validation and standardized references to be most effective.
research In vivo Pharmacokinetic Interactions of Finasteride and Identification of Novel Metabolites
Finasteride is mainly broken down by the enzyme CYP3A4, affecting its levels in the body.
research Is It Time to Re-Imagine Clinical Trials in Nephrology?
Metatrials could improve clinical research in nephrology by speeding up data collection and overcoming challenges like patient recruitment.
research Biochemical predictor for polycystic ovary syndrome
The uric acid to creatinine ratio is a strong indicator for diagnosing PCOS.
research A quantitative ultra-performance liquid chromatography high-resolution mass spectrometry analysis of steroids from human scalp hair
The method can measure multiple steroids in human hair to study long-term steroid metabolism, especially in newborns and children.
research Examination of the Elemental Composition of Hair in Cholelithiasis, Kidney Stone, Hypertension and Diabetes by Scanning Electron Microscopy and Energy Dispersive Spectrometry SEM/EDS
The study did not conclude whether hair can reliably indicate kidney stones, cholelithiasis, hypertension, or diabetes.
research Metabolomic and lipidomic atlas of human hair across its length
Human hair contains many different molecules that change along its length, influenced by personal care products.
research 103 The Effect of Evening Alcohol Consumption and Bedtime Administration of Flibanserin on the Safety of Flibanserin
Drinking alcohol before taking flibanserin does not increase the risk of severe low blood pressure or fainting.
research 138 Characterization of xenobiotic metabolizing enzymes of a reconstructed human epidermal model from adult hair follicles
The reconstructed skin model from hair follicles functions like human skin in processing chemicals and can be used to test ingredient safety.
research MULTIOMICS – A NEW EXCITING ERA OF RESEARCH
Multiomics is revolutionizing biology by enabling breakthroughs in research and disease diagnosis.
research High-throughput and direct measurement of androgen levels using turbulent flow chromatography liquid chromatography-triple quadrupole mass spectrometry (TFC-LC-TQMS) to discover chemicals that modulate dihydrotestosterone production in human prostate cancer cells
Researchers found four natural compounds that can change DHT levels in prostate cancer cells.
research Development of a new gas chromatography–mass spectrometry (GC–MS) methodology for the evaluation of 5α-reductase activity
A new method was developed to accurately measure enzyme activity related to prostate health.
research Identification of human cytochrome P450 isozymes responsible for the in vitro oxidative metabolism of finasteride.
research Multimodal Ion Beam Imaging to Correlate Elements and Metabolites at the Micron Scale Using Water Cluster Secondary Ion Mass Spectrometry and MeV Ion Beam Analysis
The method effectively images and correlates elements and metabolites in tissue samples at a micron scale.
research Profiling steroid and thyroid hormones with hair analysis in a cohort of women aged 25 to 45 years old
The method can measure multiple hormones in women's hair and may help identify hormone-related health issues.
research Effective holistic characterization of small molecule effects using heterogeneous biological networks
Integrating biological networks improves drug repurposing and ADR prediction.
research Finasteride
Finasteride is mostly broken down in the body and excreted in urine and feces.
research Biology and Detection of Pregnanes During Late Gestation in the Mare
LC-MS/MS is essential for accurately detecting pregnanes in pregnant mares.
research Preliminary pharmacokinetics and metabolism of novel non-steroidal antiandrogens in the rat: Relation of their systemic activity to the formation of a common metabolite
Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.
research GC-MS determination of steroids related to androgen biosynthesis in human hair with pentafluorophenyldimethylsilyl–trimethylsilyl derivatisation
The method accurately measures certain steroids in human hair, showing different levels in males and females.
research Genetically determined metabolites in allergic conjunctivitis: A Mendelian randomization study
Eight blood metabolites are linked to causing allergic conjunctivitis, offering new ways to predict and treat it.
research Simultaneous quantitative analysis of tamsulosin and finasteride in pharmaceutical dosage form by U-HPLC Tandem mass spectrometry
Method measures tamsulosin and finasteride in medicine accurately.
research Exploration of integrated targeted serum and hair metabolomic profiles in men with androgenetic alopecia
Men with androgenetic alopecia have unique metabolomic patterns that could help develop targeted treatments.
research BIO-ANALYTICAL METHOD DEVELOPMENT AND VALIDATION OF FINASTERIDE, TADALAFIL, AND ITS APPLICATION TO PHARMACOKINETIC STUDIES IN RAT PLASMA BY USING LC-MS/MS
A reliable method was developed to measure Finasteride and Tadalafil in rat blood.
research LC-MS/MS improves screening towards 21-hydroxylase deficiency
LC-MS/MS is more reliable than immunoassays for diagnosing 21-hydroxylase deficiency.
research Different localizations of drugs simultaneously administered in a strand of hair by micro‐segmental analysis
Drugs localize differently in hair strands based on their properties.
research Metabolite screening of aromatic amine hair dyes usingin vitrohepatic models
The tested hair dye ingredients do not form harmful oxidized metabolites in the liver.
research Human urine-based therapeutics in Spain from the early 20th century to the present
Human urine has been used in Spain for treating various skin conditions and ailments, influenced by local traditions.