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Researchers found new potential treatments for conditions related to the androgen receptor, like male hormonal contraception, by testing thousands of compounds.

PROTAC technology shows promise for cancer treatment but needs more effective E3 ligase recruiters.

Paroxetine relieves pain by increasing allopregnanolone levels.

HDAC inhibitors, like Vorinostat and Entinostat, can help regrow hair in alopecia areata.

New compounds similar to cromakalim were less effective at inhibiting insulin release but improved in solubility and one acted as a calcium entry blocker, not a potassium channel opener.

Second-generation antipsychotics offer no significant benefit over first-generation ones for schizophrenia.

Patients with the same genetic mutation for vitamin D-resistant rickets showed different symptoms but all improved with treatment except for hair loss.

Cepharanthine and tetrandrine show promise as COVID-19 drugs.

Flammulina velutipes polysaccharide helps the immune system fight tumors by activating certain pathways.

SARMs may be an effective treatment for a certain type of breast cancer by blocking cancer growth and spread.

The new anti-acne treatment HA-P5 effectively reduces acne by targeting two key receptors and avoids an enzyme that can hinder treatment.

Serlopitant may help reduce itch, but more research is needed.

Two non-steroidal antiandrogens, RU 58841 and RU 56187, form a common metabolite at different rates, which may influence their effects; RU 56187 could be used for prostate cancer treatment and RU 58841 for acne treatment.

New oral anticoagulants are safer and easier to use with new reversal agents for bleeding emergencies.

New drugs face challenges due to limited evidence, and safety updates are advised for some existing medications.

Some existing drugs and natural products might work against COVID-19 by targeting the virus's main protease.

Finasteride may help improve certain brain function issues linked to dopamine.

ERβ has potential in treating prostate cancer and neurodegenerative diseases, but human studies are needed before clinical use.

Using three different drugs together may better treat eye diseases like glaucoma and macular degeneration.

TRPV1 affects sebaceous gland function and could help treat acne.

Finasteride may improve prostate cancer treatment outcomes.

Activating TRPV3 channels stops hair growth by killing hair follicle cells.

Researchers found new potential but less potent rat enzyme inhibitors using a 3D model.

Divalproex sodium significantly improved headaches in two-thirds of patients.

TRIV-509 quickly improves skin barrier and cell health in atopic dermatitis.

Stopping alcohol after long-term use causes anxiety and changes brain chemicals.

Smaller substituents at C-17 enhance the inhibitory activity of progesterone derivatives on 5alpha-reductase.

The discovery of 5α-reductase deficiency in guevedoces led to the development of important urologic medications.

Cromakalim relaxes various blood vessels, while minoxidil sulphate is more selective; they likely act on different potassium channels.

Rosemary may help reduce dyspepsia and gastric cancer risk.